ATE352560T1 - Peptid abgeleitet von einem antigen das von antikörpern aus patienten mit rheumatoider arthritis erkannt wird, antikörper gegen dieses peptid und ein verfahren zum nachweis von autoimmunantikörpern - Google Patents

Peptid abgeleitet von einem antigen das von antikörpern aus patienten mit rheumatoider arthritis erkannt wird, antikörper gegen dieses peptid und ein verfahren zum nachweis von autoimmunantikörpern

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Publication number
ATE352560T1
ATE352560T1 AT97912577T AT97912577T ATE352560T1 AT E352560 T1 ATE352560 T1 AT E352560T1 AT 97912577 T AT97912577 T AT 97912577T AT 97912577 T AT97912577 T AT 97912577T AT E352560 T1 ATE352560 T1 AT E352560T1
Authority
AT
Austria
Prior art keywords
antibodies
peptide
rheumatoid arthritis
detecting
autoimmuno
Prior art date
Application number
AT97912577T
Other languages
English (en)
Inventor
Venrooij Waltherus Jacobus Van
Gerardus Antonius Schellekens
Jozef Maria Hendrik Raats
Rene Michael Antonius Hoet
Original Assignee
Stichting Tech Wetenschapp
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19763876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE352560(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Stichting Tech Wetenschapp filed Critical Stichting Tech Wetenschapp
Application granted granted Critical
Publication of ATE352560T1 publication Critical patent/ATE352560T1/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97912577T 1996-11-15 1997-11-14 Peptid abgeleitet von einem antigen das von antikörpern aus patienten mit rheumatoider arthritis erkannt wird, antikörper gegen dieses peptid und ein verfahren zum nachweis von autoimmunantikörpern ATE352560T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1004539A NL1004539C2 (nl) 1996-11-15 1996-11-15 Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.

Publications (1)

Publication Number Publication Date
ATE352560T1 true ATE352560T1 (de) 2007-02-15

Family

ID=19763876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97912577T ATE352560T1 (de) 1996-11-15 1997-11-14 Peptid abgeleitet von einem antigen das von antikörpern aus patienten mit rheumatoider arthritis erkannt wird, antikörper gegen dieses peptid und ein verfahren zum nachweis von autoimmunantikörpern

Country Status (13)

Country Link
US (5) US6858438B2 (de)
EP (1) EP0941244B1 (de)
JP (1) JP4197743B2 (de)
AT (1) ATE352560T1 (de)
AU (1) AU741850B2 (de)
BR (1) BR9712955A (de)
CA (1) CA2272573C (de)
DE (1) DE69737292T2 (de)
DK (1) DK0941244T3 (de)
ES (1) ES2281095T3 (de)
NL (1) NL1004539C2 (de)
PT (1) PT941244E (de)
WO (1) WO1998022503A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1004539C2 (nl) * 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
WO1999028344A2 (en) * 1997-11-28 1999-06-10 Innogenetics N.V. Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment
FR2773078B1 (fr) * 1997-12-30 2000-05-26 Univ Toulouse Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide
FR2795735B1 (fr) * 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
WO2001046222A2 (en) * 1999-12-21 2001-06-28 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
NL1019540C2 (nl) * 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
US20050048574A1 (en) * 2003-03-14 2005-03-03 Kantor Aaron B. Biomarkers for diagnosing rheumatoid arthritis
CA2546312C (en) 2003-12-23 2010-11-09 Norbert Wild Method of assessing rheumatoid arthritis by measuring anti-ccp and interleukin 6
DK1721162T3 (da) 2004-02-27 2008-12-15 Hoffmann La Roche Fremgangsmåde til at bedömme rheumatoid arthritis ved at måle anti-CCP og serumamyloid A
US20060141547A1 (en) * 2004-11-16 2006-06-29 Das Hasi R Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis
JP2010506147A (ja) 2006-09-29 2010-02-25 エフ．ホフマン−ラ ロシュ アーゲー 関節リウマチを有する患者のための疾患進行のリスク評価
ES2307421B1 (es) 2007-04-30 2009-09-28 Consejo Superiorde Investigaciones Cientificas (Csic) Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
US8323656B2 (en) * 2007-06-25 2012-12-04 Yijun Xu Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof
WO2009070875A1 (en) * 2007-12-03 2009-06-11 Sqi Diagnostics Systems Inc. Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies
GB0803107D0 (en) * 2008-02-20 2008-03-26 Axis Shield Diagnostics Ltd Method
US9683031B2 (en) * 2008-03-21 2017-06-20 Universiteit Hasselt Biomarkers for rheumatoid arthritis
EA023302B9 (ru) 2008-06-04 2016-10-31 Модиквест Б.В. Способ предотвращения или лечения артрита и применение антитела, специфически реактивного к цитруллинированному эпитопу в этом способе
EP2204655A1 (de) 2008-12-23 2010-07-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostische Prognose von rheumatoider Arthritis und systemischem Lupus erythematodes
EP2325195A1 (de) 2009-11-23 2011-05-25 Toscana Biomarkers S.r.l. Virale citrullinierte Peptide und Verwendungen dafür
EP2332987A1 (de) 2009-12-10 2011-06-15 ModiQuest B.V. Entzündungshemmende Wirkstoffe, die gegen Citrullinierte Epitope gerichtet sind
EP2336769A1 (de) 2009-12-18 2011-06-22 F. Hoffmann-La Roche AG Assay zur Unterscheidung zwischen rheumatischen und nicht rheumatischen Leiden
EP2402368A1 (de) 2010-07-02 2012-01-04 Toscana Biomarkers S.r.l. Histoncitrullinierte Peptide und deren Verwendungen
JP2014504594A (ja) * 2011-01-10 2014-02-24 オプコ ファーマシューティカルズ、エルエルシー 自己免疫疾患における抗原代用物
EP2527841A1 (de) 2011-05-25 2012-11-28 Toscana Biomarkers S.r.l. Verfahren zur Diagnose rheumatoider Arthritis
WO2013014312A1 (es) * 2011-07-28 2013-01-31 Consejo Superior De Investigaciones Científicas (Csic) Polipeptidos quimericos derivados de la proteina vimentina con utilidad para el diagnostico de la artritis reumatoide
EP3056903A1 (de) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-Casp8
CN107484423A (zh) 2015-02-13 2017-12-15 豪夫迈·罗氏有限公司 通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法
EP3056904A1 (de) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Verfahren zur Beurteilung rheumatoider Arthritis mittels Messung von Anti-CCP und Anti-MCM3
KR101758354B1 (ko) * 2015-03-26 2017-07-17 한국과학기술연구원 신규한 시클릭 시트룰리네이티드 펩티드, 이를 포함하는 류마티스 관절염 진단용 조성물 및 이를 이용한 진단 방법, 및 류마티스 관절염 마커 스크리닝 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0511116B1 (de) * 1991-04-26 2004-06-16 Clonatec S.A. Antigene, die von Polyarthritis Rheumatoide Antikörpern erkannt werden, ihre Herstellung und ihre Anwendungen
US6100377A (en) * 1994-06-10 2000-08-08 The Trustees Of The University Of Pennsylvania Constrained peptides
FR2752842B1 (fr) 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) * 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
FR2773405B1 (fr) * 1998-01-08 2000-09-29 France Telecom Procede et systeme de controle d'acces a une ressource limite a certaines plages horaires

Also Published As

Publication number Publication date
DE69737292T2 (de) 2007-06-28
EP0941244A2 (de) 1999-09-15
WO1998022503A2 (en) 1998-05-28
US20060039924A1 (en) 2006-02-23
US20140342378A1 (en) 2014-11-20
EP0941244B1 (de) 2007-01-24
PT941244E (pt) 2007-02-28
US20020137092A1 (en) 2002-09-26
US7288634B2 (en) 2007-10-30
US6858438B2 (en) 2005-02-22
AU741850B2 (en) 2001-12-13
ES2281095T3 (es) 2007-09-16
BR9712955A (pt) 1999-12-07
CA2272573C (en) 2010-02-02
US8772448B2 (en) 2014-07-08
WO1998022503A3 (en) 1998-08-27
JP4197743B2 (ja) 2008-12-17
DE69737292D1 (de) 2007-03-15
US20050186201A1 (en) 2005-08-25
CA2272573A1 (en) 1998-05-28
NL1004539C2 (nl) 1998-05-20
US20080050841A1 (en) 2008-02-28
US7335724B2 (en) 2008-02-26
DK0941244T3 (da) 2007-04-30
JP2001513753A (ja) 2001-09-04
AU4970797A (en) 1998-06-10

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