ATE262178T1 - Identifizierung und charakterisierung von interagierenden molekülen - Google Patents
Identifizierung und charakterisierung von interagierenden molekülenInfo
- Publication number
- ATE262178T1 ATE262178T1 AT98965192T AT98965192T ATE262178T1 AT E262178 T1 ATE262178 T1 AT E262178T1 AT 98965192 T AT98965192 T AT 98965192T AT 98965192 T AT98965192 T AT 98965192T AT E262178 T1 ATE262178 T1 AT E262178T1
- Authority
- AT
- Austria
- Prior art keywords
- interacting molecules
- identification
- present
- characterization
- positive clones
- Prior art date
Links
- 238000012512 characterization method Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 230000003993 interaction Effects 0.000 abstract 1
- 238000010396 two-hybrid screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Vending Machines For Individual Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97120867 | 1997-11-27 | ||
| EP97120880 | 1997-11-27 | ||
| EP97120879 | 1997-11-27 | ||
| PCT/EP1998/007656 WO1999028744A1 (en) | 1997-11-27 | 1998-11-27 | Identification and characterization of interacting molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262178T1 true ATE262178T1 (de) | 2004-04-15 |
Family
ID=27238345
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98965192T ATE262178T1 (de) | 1997-11-27 | 1998-11-27 | Identifizierung und charakterisierung von interagierenden molekülen |
| AT98965193T ATE269974T1 (de) | 1997-11-27 | 1998-11-27 | Identifizierung und charakterisierung von interagierenden molekülen mittels automatisierter interagierender paarung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98965193T ATE269974T1 (de) | 1997-11-27 | 1998-11-27 | Identifizierung und charakterisierung von interagierenden molekülen mittels automatisierter interagierender paarung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6664048B1 (de) |
| EP (3) | EP1042670B1 (de) |
| JP (3) | JP2002508517A (de) |
| AT (2) | ATE262178T1 (de) |
| AU (3) | AU1757599A (de) |
| CA (3) | CA2311896A1 (de) |
| DE (2) | DE69822510T2 (de) |
| GB (1) | GB2338711B (de) |
| IL (3) | IL136392A0 (de) |
| WO (3) | WO1999031509A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7029847B2 (en) | 2000-05-16 | 2006-04-18 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
| AU2001263155A1 (en) | 2000-05-16 | 2001-11-26 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
| DE60127867T2 (de) * | 2000-06-13 | 2008-01-17 | Glaxo Group Ltd., Greenford | Hochdurchsatzscreening von verbindungen für biologische wirksamkeit |
| DK1292710T3 (da) * | 2000-06-23 | 2007-12-27 | Domantis Ltd | Fremgangsmåde til matrix-screening |
| JP4024994B2 (ja) | 2000-06-30 | 2007-12-19 | 株式会社東芝 | 半導体発光素子 |
| AU2001278872A1 (en) | 2000-07-06 | 2002-01-21 | Genvec, Inc. | Method of identifying a binding partner of a gene product |
| ATE396539T1 (de) | 2000-07-13 | 2008-06-15 | Ct Concept Technologie Ag | Verfahren und vorrichtung zur zustandsabhängigen regelung des transienten verhaltens von leistungshalbleiterschaltern |
| AU2002213345A1 (en) * | 2000-10-13 | 2002-04-22 | Irm, Llc | High throughput processing system and method of using |
| ATE497603T1 (de) | 2001-03-02 | 2011-02-15 | Gpc Biotech Ag | Drei-hybrid-assaysystem |
| EP1243327A1 (de) * | 2001-03-19 | 2002-09-25 | BioChip Technologies GmbH | Oberfläche mit einem Muster aus Zellen und Verfahren zu deren Herstellung |
| US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| WO2002103608A2 (en) * | 2001-06-14 | 2002-12-27 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Method of expanding a biological network |
| DE10141522C1 (de) * | 2001-08-24 | 2003-03-06 | Siemens Ag | Verfahren zur Herstellung einer Leuchtstoffschicht |
| US20020094519A1 (en) * | 2002-03-07 | 2002-07-18 | Agencourt Bioscience Corporation | Detection of protein interactions |
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| US20050074780A1 (en) * | 2003-10-01 | 2005-04-07 | Bryhan Marie D. | Device for analyzing slides |
| WO2006040154A2 (en) * | 2004-10-14 | 2006-04-20 | Dublin City University | Prokaryotic two hybrid system |
| US8034180B2 (en) | 2005-10-11 | 2011-10-11 | Applied Materials, Inc. | Method of cooling a wafer support at a uniform temperature in a capacitively coupled plasma reactor |
| US7988872B2 (en) | 2005-10-11 | 2011-08-02 | Applied Materials, Inc. | Method of operating a capacitively coupled plasma reactor with dual temperature control loops |
| US8157951B2 (en) | 2005-10-11 | 2012-04-17 | Applied Materials, Inc. | Capacitively coupled plasma reactor having very agile wafer temperature control |
| US8092638B2 (en) | 2005-10-11 | 2012-01-10 | Applied Materials Inc. | Capacitively coupled plasma reactor having a cooled/heated wafer support with uniform temperature distribution |
| US20070091540A1 (en) | 2005-10-20 | 2007-04-26 | Applied Materials, Inc. | Method of processing a workpiece in a plasma reactor using multiple zone feed forward thermal control |
| US7932030B2 (en) * | 2007-04-05 | 2011-04-26 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | System for pulling out regulatory elements using yeast |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US12529164B2 (en) | 2007-09-14 | 2026-01-20 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| MX381912B (es) | 2010-07-16 | 2025-03-13 | Adimab Llc | Colecciones de anticuerpos. |
| WO2018011422A1 (en) * | 2016-07-15 | 2018-01-18 | Danmarks Tekniske Universitet | Plating cells and corresponding picking colonies |
| WO2018213343A1 (en) * | 2017-05-16 | 2018-11-22 | The Regents Of The University Of California | Fluorescence detection in yeast colonies |
| US20210147790A1 (en) * | 2019-11-06 | 2021-05-20 | General Automation Lab Technologies Inc. | Method for picking biological sample |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5789184A (en) | 1993-03-31 | 1998-08-04 | Cadus Pharmaceutical Corporation | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US5503977A (en) | 1994-04-22 | 1996-04-02 | California Institute Of Technology | Split ubiquitin protein sensor |
| EP0830459B1 (de) * | 1995-04-11 | 2007-01-24 | The General Hospital Corporation | Reverse "two-hybrid"-systeme |
| US5569588A (en) * | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| EP0790304A1 (de) * | 1995-12-21 | 1997-08-20 | AMERSHAM INTERNATIONAL plc | Auf Nachweismethoden bezogene Verbesserungen |
| US6083693A (en) * | 1996-06-14 | 2000-07-04 | Curagen Corporation | Identification and comparison of protein-protein interactions that occur in populations |
| AU4159697A (en) * | 1996-08-23 | 1998-03-06 | President And Fellows Of Harvard College | Interaction trap assay, reagents and uses thereof |
-
1998
- 1998-11-27 GB GB9923293A patent/GB2338711B/en not_active Expired - Fee Related
- 1998-11-27 AU AU17575/99A patent/AU1757599A/en not_active Abandoned
- 1998-11-27 EP EP98965192A patent/EP1042670B1/de not_active Expired - Lifetime
- 1998-11-27 EP EP98965193A patent/EP1036324B1/de not_active Expired - Lifetime
- 1998-11-27 IL IL13639298A patent/IL136392A0/xx unknown
- 1998-11-27 WO PCT/EP1998/007655 patent/WO1999031509A1/en not_active Ceased
- 1998-11-27 DE DE69822510T patent/DE69822510T2/de not_active Expired - Fee Related
- 1998-11-27 CA CA002311896A patent/CA2311896A1/en not_active Abandoned
- 1998-11-27 WO PCT/EP1998/007656 patent/WO1999028744A1/en not_active Ceased
- 1998-11-27 JP JP2000539355A patent/JP2002508517A/ja active Pending
- 1998-11-27 CA CA002311927A patent/CA2311927A1/en not_active Abandoned
- 1998-11-27 IL IL13639398A patent/IL136393A0/xx unknown
- 1998-11-27 WO PCT/EP1998/007657 patent/WO1999028745A1/en not_active Ceased
- 1998-11-27 AU AU20504/99A patent/AU762954B2/en not_active Ceased
- 1998-11-27 JP JP2000523550A patent/JP2001525186A/ja active Pending
- 1998-11-27 EP EP98962397A patent/EP1036329A1/de not_active Withdrawn
- 1998-11-27 JP JP2000523551A patent/JP2002507386A/ja active Pending
- 1998-11-27 AT AT98965192T patent/ATE262178T1/de not_active IP Right Cessation
- 1998-11-27 CA CA002311705A patent/CA2311705A1/en not_active Abandoned
- 1998-11-27 DE DE69824757T patent/DE69824757T2/de not_active Expired - Fee Related
- 1998-11-27 IL IL13639498A patent/IL136394A0/xx unknown
- 1998-11-27 AT AT98965193T patent/ATE269974T1/de not_active IP Right Cessation
- 1998-11-27 AU AU20505/99A patent/AU760908B2/en not_active Ceased
-
2000
- 2000-05-30 US US09/583,067 patent/US6664048B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69824757D1 (de) | 2004-07-29 |
| EP1042670B1 (de) | 2004-03-17 |
| EP1036329A1 (de) | 2000-09-20 |
| AU760908B2 (en) | 2003-05-22 |
| EP1042670A1 (de) | 2000-10-11 |
| GB2338711B (en) | 2000-11-15 |
| AU2050499A (en) | 1999-06-16 |
| CA2311896A1 (en) | 1999-06-24 |
| WO1999031509A1 (en) | 1999-06-24 |
| DE69824757T2 (de) | 2005-10-20 |
| CA2311927A1 (en) | 1999-06-10 |
| GB9923293D0 (en) | 1999-12-08 |
| ATE269974T1 (de) | 2004-07-15 |
| JP2002508517A (ja) | 2002-03-19 |
| EP1036324B1 (de) | 2004-06-23 |
| CA2311705A1 (en) | 1999-06-10 |
| US6664048B1 (en) | 2003-12-16 |
| JP2002507386A (ja) | 2002-03-12 |
| DE69822510D1 (de) | 2004-04-22 |
| IL136393A0 (en) | 2001-06-14 |
| IL136394A0 (en) | 2001-06-14 |
| JP2001525186A (ja) | 2001-12-11 |
| WO1999028744A1 (en) | 1999-06-10 |
| WO1999028745A1 (en) | 1999-06-10 |
| DE69822510T2 (de) | 2005-03-24 |
| GB2338711A (en) | 1999-12-29 |
| IL136392A0 (en) | 2001-06-14 |
| GB2338711A8 (en) | 2000-01-26 |
| AU1757599A (en) | 1999-07-05 |
| AU762954B2 (en) | 2003-07-10 |
| AU2050599A (en) | 1999-06-16 |
| EP1036324A1 (de) | 2000-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |