CS980283A2 - Zpusob cisteni surovych anthracyklinovych glykosidu - Google Patents

Zpusob cisteni surovych anthracyklinovych glykosidu

Info

Publication number
CS980283A2
CS980283A2 CS839802A CS980283A CS980283A2 CS 980283 A2 CS980283 A2 CS 980283A2 CS 839802 A CS839802 A CS 839802A CS 980283 A CS980283 A CS 980283A CS 980283 A2 CS980283 A2 CS 980283A2
Authority
CS
Czechoslovakia
Prior art keywords
surovych
glykosidu
anthracyklinovych
cisteni
zpusob
Prior art date
Application number
CS839802A
Other languages
English (en)
Other versions
CS258114B2 (en
Inventor
Ernesto Oppici
Carlo Varesio
Rosa O Giacoma
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of CS980283A2 publication Critical patent/CS980283A2/cs
Publication of CS258114B2 publication Critical patent/CS258114B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CS839802A 1982-12-23 1983-12-22 Method of raw anthracycline glycosides purification CS258114B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24939/82A IT1155446B (it) 1982-12-23 1982-12-23 Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine

Publications (2)

Publication Number Publication Date
CS980283A2 true CS980283A2 (en) 1987-12-17
CS258114B2 CS258114B2 (en) 1988-07-15

Family

ID=11215200

Family Applications (1)

Application Number Title Priority Date Filing Date
CS839802A CS258114B2 (en) 1982-12-23 1983-12-22 Method of raw anthracycline glycosides purification

Country Status (30)

Country Link
US (1) US4861870A (cs)
JP (2) JPS59118797A (cs)
KR (1) KR900008743B1 (cs)
AT (1) AT383601B (cs)
AU (1) AU570935B2 (cs)
BE (1) BE898506A (cs)
CA (1) CA1204738A (cs)
CH (1) CH657623A5 (cs)
CS (1) CS258114B2 (cs)
DE (1) DE3345445C2 (cs)
DK (1) DK594083A (cs)
ES (1) ES8504758A1 (cs)
FI (1) FI834650L (cs)
FR (1) FR2538394B1 (cs)
GB (1) GB2133005B (cs)
GR (1) GR79135B (cs)
HK (1) HK74887A (cs)
HU (1) HU197917B (cs)
IE (1) IE56678B1 (cs)
IL (1) IL70500A (cs)
IT (1) IT1155446B (cs)
NL (1) NL193108C (cs)
NO (1) NO834765L (cs)
NZ (1) NZ206605A (cs)
PT (1) PT77883B (cs)
SE (1) SE8307134L (cs)
SG (1) SG34587G (cs)
SU (6) SU1440350A3 (cs)
YU (1) YU247183A (cs)
ZA (1) ZA839564B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DK356087A (da) * 1987-07-09 1989-01-10 Biogal Gyogyszergyar Fremgangsmaade til isolering af et antibiotikum
US5188945A (en) * 1991-09-09 1993-02-23 American Cyanamid Company Recovery process for antibiotics ll-e19020 alpha and beta
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
DE19521419C2 (de) * 1995-06-14 1997-11-27 Plasma Applikation Mbh Ges Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen
ATE231158T1 (de) * 1997-08-28 2003-02-15 Mercian Corp Verfahren zur reinigung von daunomycin
EP1036797B1 (en) * 1997-12-05 2010-11-17 Mercian Corporation Crystalline anthracycline antibiotic and process for producing the same
KR100274787B1 (ko) * 1998-05-08 2003-10-22 보령제약 주식회사 독소루비신및이의염산염의제조정제방법
CA2347515C (en) * 1998-10-16 2009-10-13 Mercian Corporation Crystallization of doxorubicin hydrochloride
KR100351718B1 (ko) * 1999-11-02 2002-09-11 보령제약 주식회사 4'-에피-독소루비신의 정제방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
EP1638509B1 (en) * 2003-07-02 2015-12-30 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20050059156A1 (en) * 2003-08-06 2005-03-17 Pharmacia Italia S.P.A. Method for detecting contaminants in pharmaceutical products
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
AU2009329872B2 (en) 2008-12-23 2016-07-07 Gilead Pharmasset Llc Synthesis of purine nucleosides
NZ617066A (en) 2008-12-23 2015-02-27 Gilead Pharmasset Llc Nucleoside analogs
EP2301943B1 (en) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCI
ES2644990T3 (es) 2010-03-31 2017-12-01 Gilead Pharmasset Llc Síntesis estereoselectiva de principios activos que contienen fósforo
CN102120750B (zh) * 2011-01-30 2013-04-03 山东新时代药业有限公司 一种盐酸表柔比星的纯化方法
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
EP2778171A1 (en) 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
WO2017075994A1 (zh) * 2015-11-05 2017-05-11 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003383A (cs) *
US2827417A (en) * 1954-09-03 1958-03-18 Pfizer & Co C Ion exchange purification of basic antibiotics
US2960437A (en) * 1954-09-03 1960-11-15 Pfizer & Co C Ion exchange purification of basic antibiotics
US2793978A (en) * 1955-06-27 1957-05-28 Olin Mathieson Ion exchange purification of neomycin
US3221008A (en) * 1962-01-30 1965-11-30 Merck & Co Inc Ion exchange process for the recovery of ionic organic substances
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
FR1527892A (fr) * 1967-03-15 1968-06-07 Rhone Poulenc Sa Nouveau procédé de préparation de l'antibiotique 13057 r.p.
FR1593235A (cs) * 1968-11-18 1970-05-25
JPS4944347A (cs) * 1972-09-01 1974-04-26
US3882195A (en) * 1973-05-16 1975-05-06 Air Prod & Chem Pre-emulsification-delayed initiation suspension pearl polymerization process
JPS5134915B2 (cs) * 1974-07-27 1976-09-29
AU519670B2 (en) * 1975-01-22 1981-12-17 Farmitalia Carlo Erba S.R.L. Optically active daunosaminyl derivatives of anthracyclin- /nes
NL7602342A (nl) * 1975-03-13 1976-09-15 Rhone Poulenc Ind Naftaceenderivaat met antibiotische activiteit.
US4029548A (en) * 1976-05-07 1977-06-14 The Upjohn Company Process for producing antibiotics U-50,147 and U-51,738
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Also Published As

Publication number Publication date
CH657623A5 (it) 1986-09-15
ES528226A0 (es) 1985-05-01
JPS59118797A (ja) 1984-07-09
PT77883A (en) 1984-01-01
IL70500A0 (en) 1984-03-30
JPH0439476B2 (cs) 1992-06-29
GR79135B (cs) 1984-10-02
AU2245583A (en) 1984-06-28
NL193108C (nl) 1998-11-03
JPH07252291A (ja) 1995-10-03
SE8307134L (sv) 1984-06-24
CS258114B2 (en) 1988-07-15
FI834650A0 (fi) 1983-12-16
DK594083A (da) 1984-06-24
BE898506A (fr) 1984-04-16
DE3345445A1 (de) 1984-06-28
SU1450747A3 (ru) 1989-01-07
IT1155446B (it) 1987-01-28
US4861870A (en) 1989-08-29
FR2538394B1 (fr) 1986-03-28
ATA440083A (de) 1986-12-15
ES8504758A1 (es) 1985-05-01
SU1470197A3 (ru) 1989-03-30
PT77883B (en) 1986-04-09
SU1575943A3 (ru) 1990-06-30
SU1440350A3 (ru) 1988-11-23
IL70500A (en) 1990-07-12
YU247183A (en) 1985-10-31
GB2133005A (en) 1984-07-18
KR840007438A (ko) 1984-12-07
KR900008743B1 (ko) 1990-11-29
ZA839564B (en) 1984-08-29
AT383601B (de) 1987-07-27
NZ206605A (en) 1987-02-20
SU1447287A3 (ru) 1988-12-23
NL193108B (nl) 1998-07-01
JP2749272B2 (ja) 1998-05-13
IE56678B1 (en) 1991-11-06
DK594083D0 (da) 1983-12-22
HK74887A (en) 1987-10-23
SG34587G (en) 1988-03-04
IT8224939A0 (it) 1982-12-23
CA1204738A (en) 1986-05-20
HUT35270A (en) 1985-06-28
SU1450748A3 (ru) 1989-01-07
FR2538394A1 (fr) 1984-06-29
IE833060L (en) 1984-06-23
AU570935B2 (en) 1988-03-31
GB8333511D0 (en) 1984-01-25
SE8307134D0 (sv) 1983-12-22
NL8304327A (nl) 1984-07-16
HU197917B (en) 1989-06-28
GB2133005B (en) 1986-04-30
FI834650A7 (fi) 1984-06-24
FI834650L (fi) 1984-06-24
NO834765L (no) 1984-06-25
DE3345445C2 (de) 1995-09-21

Similar Documents

Publication Publication Date Title
CS203883A2 (en) Zpusob pripravy perletove lesklych pigmentu
CS124683A2 (en) Zpusob zapouzdreni ucinne latky chemickeho prostredku
CS980283A2 (en) Zpusob cisteni surovych anthracyklinovych glykosidu
CS102482A1 (en) Stabilizacni zarizeni plasmoveho generatoru
CA50163S (en) Skillet-oven
CA50660S (en) Gamesboard
CS221882A1 (en) Zapojeni rozdelovace elektrickeho ovladaciho napeti
CS11382A1 (en) Abrazivna guma
CS243282A1 (en) Zmesny koagulator vodneho skla
CS231982A1 (en) Zpusob oxonace propylenu
CS222782A1 (en) Selektivni kapkovy detektor
CS222096B1 (en) Drybunolaktonu
CS228182A1 (en) Zpusob odstranovani kazove vrstvy chromu
CS211582A1 (en) Davkovac tekutin
CS208482A1 (en) Uzavrene samostredici upinadlo
CS246682A1 (en) Zpusob pripravy fluorovanych diazaalkanu
CS202883A1 (en) Zpusob vyroby kovovych vlaken
CS194582A2 (en) Numericka koule
CS168782A1 (en) Spodni resonancni deska smyccovych nastroju
CS168282A1 (en) Pracovni revolverova jednotka
CS156182A1 (en) Stabilizovany zdroj sinusoveho prudu
CS151782A1 (en) Odstredivy odlucovac
CS151482A1 (en) Rohova dverni zaruben
CS129983A1 (en) Indikator brzdove polohy
CS248782A1 (en) Magneticka hlava