CS277611B6 - 3-(2,2,5,6-tetrahydropyridyl)-pyrrolopyridine derivatives - Google Patents

3-(2,2,5,6-tetrahydropyridyl)-pyrrolopyridine derivatives Download PDF

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Publication number
CS277611B6
CS277611B6 CS90260A CS26090A CS277611B6 CS 277611 B6 CS277611 B6 CS 277611B6 CS 90260 A CS90260 A CS 90260A CS 26090 A CS26090 A CS 26090A CS 277611 B6 CS277611 B6 CS 277611B6
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CS
Czechoslovakia
Prior art keywords
compound
group
nmr
mmol
carbon atoms
Prior art date
Application number
CS90260A
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Czech (cs)
English (en)
Other versions
CS26090A3 (en
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS26090A3 publication Critical patent/CS26090A3/cs
Publication of CS277611B6 publication Critical patent/CS277611B6/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CS90260A 1989-01-20 1990-01-18 3-(2,2,5,6-tetrahydropyridyl)-pyrrolopyridine derivatives CS277611B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (2)

Publication Number Publication Date
CS26090A3 CS26090A3 (en) 1992-02-19
CS277611B6 true CS277611B6 (en) 1993-03-17

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
CS90260A CS277611B6 (en) 1989-01-20 1990-01-18 3-(2,2,5,6-tetrahydropyridyl)-pyrrolopyridine derivatives

Country Status (26)

Country Link
US (2) US5051412A (ko)
EP (1) EP0379314B1 (ko)
JP (1) JPH0751576B2 (ko)
KR (1) KR920010642B1 (ko)
CN (1) CN1025998C (ko)
AT (1) ATE103282T1 (ko)
CA (1) CA2008016A1 (ko)
CS (1) CS277611B6 (ko)
DD (2) DD291559A5 (ko)
DE (1) DE69007501T2 (ko)
DK (1) DK0379314T3 (ko)
EG (1) EG18945A (ko)
ES (1) ES2062319T3 (ko)
FI (1) FI94641C (ko)
HU (1) HU206349B (ko)
IE (1) IE62757B1 (ko)
IL (1) IL93041A (ko)
MX (1) MX19185A (ko)
MY (1) MY106305A (ko)
NO (1) NO912860D0 (ko)
NZ (1) NZ232166A (ko)
PL (2) PL287840A1 (ko)
PT (1) PT92889A (ko)
WO (1) WO1990007926A1 (ko)
YU (1) YU47553B (ko)
ZA (1) ZA90393B (ko)

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US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
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RU2006121990A (ru) * 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) Ингибиторы протеинкиназ акт
KR20070053236A (ko) * 2004-07-27 2007-05-23 에스지엑스 파마슈티컬스, 인코포레이티드 융합 고리 헤테로사이클 키나제 조절제
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
AU2005269386A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
JP5231410B2 (ja) 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン
KR101527232B1 (ko) 2006-07-06 2015-06-09 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 시클로펜타〔ｄ〕피리미딘
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CA2656364C (en) 2006-07-06 2014-11-25 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
WO2008083357A1 (en) * 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
SG185274A1 (en) 2007-07-05 2012-11-29 Array Biopharma Inc Pyrimidyl cyclopentanes as akt protein kinase inhibitors
KR101624361B1 (ko) * 2007-07-05 2016-05-25 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
KR101624752B1 (ko) * 2008-01-09 2016-05-26 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
KR101624753B1 (ko) * 2008-01-09 2016-05-26 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
ES2528032T3 (es) 2009-01-16 2015-02-03 Rigel Pharmaceuticals, Inc. Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico
JP5721706B2 (ja) 2009-06-17 2015-05-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルス複製の阻害剤
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
PL2694073T3 (pl) 2011-04-01 2019-06-28 Genentech, Inc. Kombinacje inhibitorów AKT i MEK do leczenia nowotworu
KR20140025434A (ko) 2011-04-01 2014-03-04 제넨테크, 인크. Akt 억제제 화합물 및 화학요법제의 조합물, 및 사용 방법
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
HK1215170A1 (zh) 2012-11-14 2016-08-19 The Johns Hopkins University 治療精神分裂症的方法和組合物
PT3068782T (pt) 2013-11-13 2018-10-08 Vertex Pharma Métodos de preparação de inibidores da replicação de vírus da gripe
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
US10323045B2 (en) 2014-10-23 2019-06-18 Janssen Pharmaceutica Nv Thienopyrimidine derivatives as NIK inhibitors
AU2015334915B2 (en) * 2014-10-23 2019-09-19 Janssen Pharmaceutica Nv New pyrazolopyrimidine derivatives as NIK inhibitors
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe

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US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
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WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
AU4867390A (en) 1990-07-26
DE69007501T2 (de) 1994-06-30
ATE103282T1 (de) 1994-04-15
NO912860L (no) 1991-07-22
IE62757B1 (en) 1995-02-22
MY106305A (en) 1995-04-29
EP0379314A1 (en) 1990-07-25
FI94641C (fi) 1995-10-10
EG18945A (en) 1994-09-29
PL163626B1 (pl) 1994-04-29
PL283354A1 (en) 1991-08-12
IE900210L (en) 1990-07-23
KR920010642B1 (ko) 1992-12-12
CN1025998C (zh) 1994-09-28
JPH0751576B2 (ja) 1995-06-05
ES2062319T3 (es) 1994-12-16
YU47553B (sh) 1995-10-03
IL93041A (en) 1994-02-27
CS26090A3 (en) 1992-02-19
NZ232166A (en) 1992-10-28
PL287840A1 (en) 1991-07-15
CN1044465A (zh) 1990-08-08
US5169947A (en) 1992-12-08
PT92889A (pt) 1990-07-31
AU613259B2 (en) 1991-07-25
MX19185A (es) 1993-12-01
WO1990007926A1 (en) 1990-07-26
DE69007501D1 (de) 1994-04-28
NO912860D0 (no) 1991-07-22
IL93041A0 (en) 1990-11-05
ZA90393B (en) 1991-08-28
FI94641B (fi) 1995-06-30
HUT57762A (en) 1991-12-30
CA2008016A1 (en) 1990-07-20
JPH02247175A (ja) 1990-10-02
DK0379314T3 (da) 1994-05-09
HU206349B (en) 1992-10-28
EP0379314B1 (en) 1994-03-23
KR900011772A (ko) 1990-08-02
DD291559A5 (de) 1991-07-04
DD298398A5 (de) 1992-02-20
US5051412A (en) 1991-09-24
FI913509A0 (fi) 1991-07-22
YU9990A (en) 1992-05-28

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050118