DK0379314T3 - 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner - Google Patents

3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner

Info

Publication number
DK0379314T3
DK0379314T3 DK90300361.4T DK90300361T DK0379314T3 DK 0379314 T3 DK0379314 T3 DK 0379314T3 DK 90300361 T DK90300361 T DK 90300361T DK 0379314 T3 DK0379314 T3 DK 0379314T3
Authority
DK
Denmark
Prior art keywords
alkyl
tetrahydropyridyl
alkoxy
formula
pyrrolopyridiner
Prior art date
Application number
DK90300361.4T
Other languages
Danish (da)
English (en)
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0379314T3 publication Critical patent/DK0379314T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK90300361.4T 1989-01-20 1990-01-12 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner DK0379314T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (1)

Publication Number Publication Date
DK0379314T3 true DK0379314T3 (da) 1994-05-09

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90300361.4T DK0379314T3 (da) 1989-01-20 1990-01-12 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner

Country Status (26)

Country Link
US (2) US5051412A (ko)
EP (1) EP0379314B1 (ko)
JP (1) JPH0751576B2 (ko)
KR (1) KR920010642B1 (ko)
CN (1) CN1025998C (ko)
AT (1) ATE103282T1 (ko)
CA (1) CA2008016A1 (ko)
CS (1) CS277611B6 (ko)
DD (2) DD298398A5 (ko)
DE (1) DE69007501T2 (ko)
DK (1) DK0379314T3 (ko)
EG (1) EG18945A (ko)
ES (1) ES2062319T3 (ko)
FI (1) FI94641C (ko)
HU (1) HU206349B (ko)
IE (1) IE62757B1 (ko)
IL (1) IL93041A (ko)
MX (1) MX19185A (ko)
MY (1) MY106305A (ko)
NO (1) NO912860D0 (ko)
NZ (1) NZ232166A (ko)
PL (2) PL287840A1 (ko)
PT (1) PT92889A (ko)
WO (1) WO1990007926A1 (ko)
YU (1) YU47553B (ko)
ZA (1) ZA90393B (ko)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
EP1575566B1 (en) 2002-12-26 2012-02-22 Pozen, Inc. Multilayer dosage forms containing naproxen and triptans
CN1882347A (zh) * 2003-11-21 2006-12-20 阿雷生物药品公司 Akt蛋白激酶抑制剂
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
NZ553267A (en) * 2004-07-27 2010-09-30 Sgx Pharmaceuticals Inc Pyrrolo-pyridine kinase modulators
BRPI0513899A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de cinase heterocìclica de anel fundido
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
EP2054418B1 (en) 2006-07-06 2011-11-09 Array Biopharma Inc. Dihydrothieno pyrimidines as akt protein kinase inhibitors
BRPI0713555A2 (pt) 2006-07-06 2012-03-20 Array Biopharma, Inc. ciclopenta [d] pirimidinas como inibidores de akt protéina cinase
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
ES2404668T3 (es) * 2006-12-29 2013-05-28 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692506C (en) * 2007-07-05 2015-11-24 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
AU2008272830B8 (en) 2007-07-05 2013-12-12 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
NZ586346A (en) * 2008-01-09 2012-02-24 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
MX2010007546A (es) * 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
PT2387395E (pt) 2009-01-16 2015-02-04 Rigel Pharmaceuticals Inc Inibidores de axl para utilização em terapia de combinação para prevenir, tratar ou gerir cancro metastático
WO2010148197A1 (en) 2009-06-17 2010-12-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN103841976A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
HUE036513T2 (hu) 2011-04-01 2018-07-30 Genentech Inc AKT inhibitor vegyület és abirateron kombinációja terápiás kezelésekben való alkalmazásra
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP6615755B2 (ja) 2013-11-13 2019-12-04 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルスの複製の阻害剤
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
US10323045B2 (en) 2014-10-23 2019-06-18 Janssen Pharmaceutica Nv Thienopyrimidine derivatives as NIK inhibitors
JP6616412B2 (ja) * 2014-10-23 2019-12-04 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のピラゾロピリミジン誘導体
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.

Also Published As

Publication number Publication date
YU9990A (en) 1992-05-28
MY106305A (en) 1995-04-29
ZA90393B (en) 1991-08-28
IE900210L (en) 1990-07-23
CN1025998C (zh) 1994-09-28
DE69007501D1 (de) 1994-04-28
DD298398A5 (de) 1992-02-20
DE69007501T2 (de) 1994-06-30
CS26090A3 (en) 1992-02-19
AU613259B2 (en) 1991-07-25
IE62757B1 (en) 1995-02-22
KR900011772A (ko) 1990-08-02
EG18945A (en) 1994-09-29
FI94641C (fi) 1995-10-10
YU47553B (sh) 1995-10-03
US5169947A (en) 1992-12-08
PL283354A1 (en) 1991-08-12
ES2062319T3 (es) 1994-12-16
DD291559A5 (de) 1991-07-04
HUT57762A (en) 1991-12-30
MX19185A (es) 1993-12-01
KR920010642B1 (ko) 1992-12-12
JPH02247175A (ja) 1990-10-02
NO912860L (no) 1991-07-22
IL93041A0 (en) 1990-11-05
PT92889A (pt) 1990-07-31
CA2008016A1 (en) 1990-07-20
US5051412A (en) 1991-09-24
WO1990007926A1 (en) 1990-07-26
CN1044465A (zh) 1990-08-08
ATE103282T1 (de) 1994-04-15
IL93041A (en) 1994-02-27
FI94641B (fi) 1995-06-30
CS277611B6 (en) 1993-03-17
EP0379314B1 (en) 1994-03-23
AU4867390A (en) 1990-07-26
JPH0751576B2 (ja) 1995-06-05
NO912860D0 (no) 1991-07-22
NZ232166A (en) 1992-10-28
PL287840A1 (en) 1991-07-15
PL163626B1 (pl) 1994-04-29
FI913509A0 (fi) 1991-07-22
HU206349B (en) 1992-10-28
EP0379314A1 (en) 1990-07-25

Similar Documents

Publication Publication Date Title
DK0379314T3 (da) 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner
CS845583A2 (en) Zpusob pripravy 4 ep homoerythromycinu a
FI945703A0 (fi) 3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus
ES8605821A1 (es) Un procedimiento para la preparacion de aciltripeptidos in- munoestimulantes
AU2215588A (en) Substituted cycloalkanols
NZ228632A (en) Topical otopathic preparations containing ofloxacin
GR3024925T3 (en) Antifungal agent, its preparation and microorganism therefor
GR3036754T3 (en) Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers
DE59300623D1 (de) Führung für den Schaft eines Offenend-Spinnrotors.
KR880701707A (ko) 2,3-디아미노아크릴로니트릴 유도체
ZA200003035B (en) Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[B]-pyrano[3,2-H] acridin carboxylate, a process for their preparation and pharmaceutical compositions containing them.
EP0116255A3 (en) Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives
FI945750A (fi) 3-(fenyylialkyyliaminoalkyylioksi)-5-fenyylipyratsoli-yhdisteet sekä menetelmät ja välituotteet niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
NL7705801A (en) Analgesic decahydro-isoquinolines - with 4A phenyl substits.
PT81324A (en) Process for the preparation of s-aralkyltrithiophosphonate having an insecticidal effect
EP0171812A3 (en) Cephem derivatives
CS153685A1 (en) Treatment method of staple yarn spinned by rotor system
HUP9903171A2 (hu) Duloxetin alkalmazása figyelemcsökkenéssel/hiperaktivitással kapcsolatos rendellenességek kezelésére alkalmas gyógyászati készítmények előállítására
ES8609254A1 (es) Un procedimiento para preparar un derivado de piridinodicar-boxilato
IT8722133A0 (it) Complesso di motorizzazione singola, ad intercambiabilita'facilitata, per l'azionamento individuale di fusi di macchine tessili a fusi.