CS845583A2 - Zpusob pripravy 4 ep homoerythromycinu a - Google Patents

Zpusob pripravy 4 ep homoerythromycinu a

Info

Publication number
CS845583A2
CS845583A2 CS838455A CS845583A CS845583A2 CS 845583 A2 CS845583 A2 CS 845583A2 CS 838455 A CS838455 A CS 838455A CS 845583 A CS845583 A CS 845583A CS 845583 A2 CS845583 A2 CS 845583A2
Authority
CS
Czechoslovakia
Prior art keywords
homoerythromycinu
erythromycin
zpusob pripravy
antibacterially
amounts
Prior art date
Application number
CS838455A
Other languages
Czech (cs)
Other versions
CS241069B2 (en
Inventor
Gene M Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS847926A priority Critical patent/CS241099B2/en
Publication of CS845583A2 publication Critical patent/CS845583A2/en
Publication of CS241069B2 publication Critical patent/CS241069B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Cosmetics (AREA)

Abstract

Antibacterial 4 sec -epi-9-deoxo-9a-methyl-9a-aza-9a-homo-erythromycin A, pharmaceutically-acceptable salts thereof, pharmaceutical compositions comprising antibacterially-effectife amounts thereof, a method of treatment of bacterial infections with antibacterially effective amounts thereof, and intermediates for the synthesis thereof from erythromycin A.
CS838455A 1982-11-15 1983-11-15 Method of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycine a preparation CS241069B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS847926A CS241099B2 (en) 1982-11-15 1983-11-15 Method of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycine a preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15

Publications (2)

Publication Number Publication Date
CS845583A2 true CS845583A2 (en) 1985-07-16
CS241069B2 CS241069B2 (en) 1986-03-13

Family

ID=23755068

Family Applications (1)

Application Number Title Priority Date Filing Date
CS838455A CS241069B2 (en) 1982-11-15 1983-11-15 Method of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycine a preparation

Country Status (26)

Country Link
EP (1) EP0109253B1 (en)
JP (1) JPS59104398A (en)
KR (1) KR850000968B1 (en)
AT (1) ATE30237T1 (en)
AU (1) AU544790B2 (en)
CA (1) CA1239639A (en)
CS (1) CS241069B2 (en)
DD (1) DD216017A5 (en)
DE (1) DE3374065D1 (en)
DK (1) DK159322C (en)
EG (1) EG16641A (en)
ES (2) ES8600327A1 (en)
FI (1) FI72980C (en)
GR (1) GR79425B (en)
GT (1) GT198304062A (en)
HU (1) HU193886B (en)
IE (1) IE56234B1 (en)
IL (1) IL70228A (en)
NO (1) NO160262C (en)
NZ (1) NZ206259A (en)
PH (2) PH19293A (en)
PL (2) PL142601B1 (en)
PT (1) PT77645B (en)
SU (1) SU1272996A3 (en)
YU (2) YU43198B (en)
ZA (1) ZA838460B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
ATE38519T1 (en) * 1983-09-06 1988-11-15 Pfizer AZAHOMOERYTHROMYCIN-B DERIVATIVES AND INTERMEDIATE PRODUCTS.
RO107257B1 (en) * 1987-07-09 1993-10-30 Pfizer Preparation process of a crystalline azitromicine dihydrate
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (en) * 1988-05-19 1998-05-18 大正製薬株式会社 Process for producing erythromycin A oxime and its salt
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
SI8911498B (en) * 1989-07-26 1998-10-31 Pliva Process for the preparation of tylosin derivatives
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
EP0515141A1 (en) * 1991-05-20 1992-11-25 Merck & Co. Inc. Novel process for the preparation of 8A-aza-8A-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
MX9605419A (en) * 1994-05-06 1997-12-31 Pfizer Liquid detergent containing polyhydroxy fatty acid amide and toluene sulfonate salt.
CZ290072B6 (en) * 1995-06-29 2002-05-15 Texas Biotechnology Corporation Di- and trivalent small molecules of selectin inhibitors
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
PT102006B (en) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A NEW AZITROMYCIN PREPARATION PROCESS
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
MXPA02001897A (en) * 1999-08-24 2002-10-31 Abbott Lab 9a azalides with antibacterial activity.
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6586576B2 (en) * 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
AU2001280000A1 (en) 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053656A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053651A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
SI1691787T1 (en) 2003-12-04 2008-10-31 Pfizer Prod Inc Method for making pharmaceutical multiparticulates
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
RU2256665C1 (en) * 2004-01-29 2005-07-20 Открытое акционерное общество Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Method for preparing erythromycin oxime

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
HU193886B (en) 1987-12-28
FI72980C (en) 1987-08-10
YU197285A (en) 1986-08-31
ES527249A0 (en) 1985-10-01
NO834146L (en) 1984-05-16
FI834163L (en) 1984-05-16
IE56234B1 (en) 1991-05-22
PT77645B (en) 1986-05-12
KR850000968B1 (en) 1985-07-02
ES8604257A1 (en) 1986-01-16
GR79425B (en) 1984-10-22
SU1272996A3 (en) 1986-11-23
IE832652L (en) 1984-05-15
EP0109253A2 (en) 1984-05-23
DK518683A (en) 1984-05-16
ES8600327A1 (en) 1985-10-01
YU43425B (en) 1989-06-30
DK159322B (en) 1990-10-01
IL70228A0 (en) 1984-02-29
PL143281B1 (en) 1988-01-30
ATE30237T1 (en) 1987-10-15
NO160262C (en) 1989-03-29
JPH0140038B2 (en) 1989-08-24
PT77645A (en) 1983-12-01
DK159322C (en) 1991-02-25
PH21560A (en) 1987-12-11
EP0109253A3 (en) 1984-09-12
DD216017A5 (en) 1984-11-28
NZ206259A (en) 1986-08-08
EP0109253B1 (en) 1987-10-14
PL142601B1 (en) 1987-11-30
DE3374065D1 (en) 1987-11-19
ZA838460B (en) 1985-06-26
YU43198B (en) 1989-04-30
CS241069B2 (en) 1986-03-13
EG16641A (en) 1990-08-30
KR840006673A (en) 1984-12-01
JPS59104398A (en) 1984-06-16
FI834163A0 (en) 1983-11-14
YU224383A (en) 1986-04-30
HUT35273A (en) 1985-06-28
PH19293A (en) 1986-03-04
PL250350A1 (en) 1985-04-24
ES543638A0 (en) 1986-01-16
FI72980B (en) 1987-04-30
PL244557A1 (en) 1985-03-26
AU544790B2 (en) 1985-06-13
CA1239639A (en) 1988-07-26
AU2130983A (en) 1984-05-24
DK518683D0 (en) 1983-11-14
IL70228A (en) 1987-03-31
GT198304062A (en) 1985-05-04
NO160262B (en) 1988-12-19

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