CS845583A2 - Zpusob pripravy 4 ep homoerythromycinu a - Google Patents

Zpusob pripravy 4 ep homoerythromycinu a

Info

Publication number
CS845583A2
CS845583A2 CS838455A CS845583A CS845583A2 CS 845583 A2 CS845583 A2 CS 845583A2 CS 838455 A CS838455 A CS 838455A CS 845583 A CS845583 A CS 845583A CS 845583 A2 CS845583 A2 CS 845583A2
Authority
CS
Czechoslovakia
Prior art keywords
homoerythromycinu
erythromycin
zpusob pripravy
antibacterially
amounts
Prior art date
Application number
CS838455A
Other languages
English (en)
Other versions
CS241069B2 (en
Inventor
Gene M Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS847926A priority Critical patent/CS241099B2/cs
Publication of CS845583A2 publication Critical patent/CS845583A2/cs
Publication of CS241069B2 publication Critical patent/CS241069B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CS838455A 1982-11-15 1983-11-15 Method of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycine a preparation CS241069B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS847926A CS241099B2 (cs) 1982-11-15 1983-11-15 Způsob přípravy 4“-epi-9-deoxo-9a-methyl-9a-aza- -9a-bomoerythromycinu A

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15

Publications (2)

Publication Number Publication Date
CS845583A2 true CS845583A2 (en) 1985-07-16
CS241069B2 CS241069B2 (en) 1986-03-13

Family

ID=23755068

Family Applications (1)

Application Number Title Priority Date Filing Date
CS838455A CS241069B2 (en) 1982-11-15 1983-11-15 Method of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycine a preparation

Country Status (26)

Country Link
EP (1) EP0109253B1 (cs)
JP (1) JPS59104398A (cs)
KR (1) KR850000968B1 (cs)
AT (1) ATE30237T1 (cs)
AU (1) AU544790B2 (cs)
CA (1) CA1239639A (cs)
CS (1) CS241069B2 (cs)
DD (1) DD216017A5 (cs)
DE (1) DE3374065D1 (cs)
DK (1) DK159322C (cs)
EG (1) EG16641A (cs)
ES (2) ES8600327A1 (cs)
FI (1) FI72980C (cs)
GR (1) GR79425B (cs)
GT (1) GT198304062A (cs)
HU (1) HU193886B (cs)
IE (1) IE56234B1 (cs)
IL (1) IL70228A (cs)
NO (1) NO160262C (cs)
NZ (1) NZ206259A (cs)
PH (2) PH19293A (cs)
PL (2) PL143281B1 (cs)
PT (1) PT77645B (cs)
SU (1) SU1272996A3 (cs)
YU (2) YU43198B (cs)
ZA (1) ZA838460B (cs)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0136831B1 (en) * 1983-09-06 1988-11-09 Pfizer Inc. Azahomoerythromycin b derivatives and intermediates thereof
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
MX12213A (es) * 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
YU149889A (en) * 1989-07-26 1991-02-28 Pliva Zagreb Process for preparing biologically active derivatives of tylozine
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
EP0515141A1 (en) * 1991-05-20 1992-11-25 Merck & Co. Inc. Novel process for the preparation of 8A-aza-8A-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
EP0758244B2 (en) * 1994-05-06 2008-02-13 Pfizer Inc. Controlled-release dosage forms of azithromycin
CZ290072B6 (cs) * 1995-06-29 2002-05-15 Texas Biotechnology Corporation Di- a trivalentní malé molekuly selektinových inhibitorů
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
AU6748500A (en) * 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
DE60133083D1 (de) * 2000-01-04 2008-04-17 Teva Pharma Verfahren zur herstellung von azithromycin-dihydrat
CA2419873A1 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2549225A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
BRPI0416534A (pt) 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
RU2331410C2 (ru) 2003-12-04 2008-08-20 Пфайзер Продактс Инк. Способ получения фармацевтических мультичастиц
RU2256665C1 (ru) * 2004-01-29 2005-07-20 Открытое акционерное общество Акционерное Курганское общество медицинских препаратов и изделий "Синтез" Способ получения оксима эритромицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
JPS59104398A (ja) 1984-06-16
DD216017A5 (de) 1984-11-28
NO160262C (no) 1989-03-29
YU224383A (en) 1986-04-30
FI834163A0 (fi) 1983-11-14
EG16641A (en) 1990-08-30
YU43425B (en) 1989-06-30
PH19293A (en) 1986-03-04
FI834163L (fi) 1984-05-16
DK159322C (da) 1991-02-25
FI72980B (fi) 1987-04-30
EP0109253A3 (en) 1984-09-12
GT198304062A (es) 1985-05-04
EP0109253B1 (en) 1987-10-14
IE832652L (en) 1984-05-15
DK518683D0 (da) 1983-11-14
IL70228A (en) 1987-03-31
IE56234B1 (en) 1991-05-22
DE3374065D1 (en) 1987-11-19
PH21560A (en) 1987-12-11
PT77645A (en) 1983-12-01
JPH0140038B2 (cs) 1989-08-24
ES527249A0 (es) 1985-10-01
PL143281B1 (en) 1988-01-30
DK518683A (da) 1984-05-16
GR79425B (cs) 1984-10-22
PT77645B (en) 1986-05-12
KR850000968B1 (ko) 1985-07-02
AU2130983A (en) 1984-05-24
ZA838460B (en) 1985-06-26
DK159322B (da) 1990-10-01
HU193886B (en) 1987-12-28
PL244557A1 (en) 1985-03-26
NZ206259A (en) 1986-08-08
HUT35273A (en) 1985-06-28
NO834146L (no) 1984-05-16
AU544790B2 (en) 1985-06-13
NO160262B (no) 1988-12-19
ES8604257A1 (es) 1986-01-16
ES8600327A1 (es) 1985-10-01
ATE30237T1 (de) 1987-10-15
SU1272996A3 (ru) 1986-11-23
IL70228A0 (en) 1984-02-29
ES543638A0 (es) 1986-01-16
EP0109253A2 (en) 1984-05-23
YU43198B (en) 1989-04-30
PL250350A1 (en) 1985-04-24
FI72980C (fi) 1987-08-10
CA1239639A (en) 1988-07-26
CS241069B2 (en) 1986-03-13
KR840006673A (ko) 1984-12-01
YU197285A (en) 1986-08-31
PL142601B1 (en) 1987-11-30

Similar Documents

Publication Publication Date Title
CS845583A2 (en) Zpusob pripravy 4 ep homoerythromycinu a
EP0136830A3 (en) Azahomoerythromycin d derivative and intermediates therefor
MY104109A (en) Antibacterial 9-deoxo-9a-allyl and propargyl-9a-aza-9a-homoerythromycin a derivatives.
DE3475073D1 (en) Azahomoerythromycin b derivatives and intermediates thereof
HU9202163D0 (en) New glyco-peptides, method for producing them and pharmaceutical preparatives containing these compounds
DE3170503D1 (en) 3-0-demethyl derivatives of istamycin b series compounds and their preparation
ES8300773A1 (es) "un procedimiento para la preparacion de derivados de metoxicefalosporinas".
YU147385A (en) Process for obtaining new antibiotics
ES8501407A1 (es) Un procedimiento para la obtencion de nuevos derivados de cefalosporina.