DK518683A - Fremgangsmaade til fremstilling af 4aeepi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaaden - Google Patents

Fremgangsmaade til fremstilling af 4aeepi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaaden Download PDF

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Publication number
DK518683A
DK518683A DK518683A DK518683A DK518683A DK 518683 A DK518683 A DK 518683A DK 518683 A DK518683 A DK 518683A DK 518683 A DK518683 A DK 518683A DK 518683 A DK518683 A DK 518683A
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DK
Denmark
Prior art keywords
deoxo
aza
methyl
4aeepi
homoerythromycin
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DK518683A
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English (en)
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DK518683D0 (da
DK159322B (da
DK159322C (da
Inventor
Gene Michael Bright
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Pfizer
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Publication date
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Publication of DK518683D0 publication Critical patent/DK518683D0/da
Publication of DK518683A publication Critical patent/DK518683A/da
Publication of DK159322B publication Critical patent/DK159322B/da
Application granted granted Critical
Publication of DK159322C publication Critical patent/DK159322C/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DK518683A 1982-11-15 1983-11-14 Analogifremgangsmaade til fremstilling af 4ae-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og 4ae-epi-9-deoxy-9a-aza-9a-homoerythromycin a til anvendelse som udgangsmateriale ved fremgangsmaaden DK159322C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15
US44197982 1982-11-15

Publications (4)

Publication Number Publication Date
DK518683D0 DK518683D0 (da) 1983-11-14
DK518683A true DK518683A (da) 1984-05-16
DK159322B DK159322B (da) 1990-10-01
DK159322C DK159322C (da) 1991-02-25

Family

ID=23755068

Family Applications (1)

Application Number Title Priority Date Filing Date
DK518683A DK159322C (da) 1982-11-15 1983-11-14 Analogifremgangsmaade til fremstilling af 4ae-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og 4ae-epi-9-deoxy-9a-aza-9a-homoerythromycin a til anvendelse som udgangsmateriale ved fremgangsmaaden

Country Status (26)

Country Link
EP (1) EP0109253B1 (da)
JP (1) JPS59104398A (da)
KR (1) KR850000968B1 (da)
AT (1) ATE30237T1 (da)
AU (1) AU544790B2 (da)
CA (1) CA1239639A (da)
CS (1) CS241069B2 (da)
DD (1) DD216017A5 (da)
DE (1) DE3374065D1 (da)
DK (1) DK159322C (da)
EG (1) EG16641A (da)
ES (2) ES527249A0 (da)
FI (1) FI72980C (da)
GR (1) GR79425B (da)
GT (1) GT198304062A (da)
HU (1) HU193886B (da)
IE (1) IE56234B1 (da)
IL (1) IL70228A (da)
NO (1) NO160262C (da)
NZ (1) NZ206259A (da)
PH (2) PH19293A (da)
PL (2) PL143281B1 (da)
PT (1) PT77645B (da)
SU (1) SU1272996A3 (da)
YU (2) YU43198B (da)
ZA (1) ZA838460B (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR80277B (en) * 1983-09-06 1985-01-04 Pfizer Azahomoerythromycin b derivatives and intermediates therefor
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
SI8911498B (sl) * 1989-07-26 1998-10-31 Pliva Postopek za pripravo derivatov tilozina
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
ES2163504T5 (es) * 1994-05-06 2008-05-16 Pfizer Inc. Formas de dosificacion de liberacion controlada de azitromicina.
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
BR0009101A (pt) * 1999-08-24 2002-02-05 Abbott Lab 9a-azalidas com atividade antibacteriana
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
WO2001049697A1 (en) * 2000-01-04 2001-07-12 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
AU2001280000A1 (en) 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
BRPI0416534A (pt) 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
PT1691787E (pt) 2003-12-04 2008-09-02 Pfizer Prod Inc Método de formação de multipartículas farmacêuticas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
EP0109253A2 (en) 1984-05-23
PT77645B (en) 1986-05-12
PL250350A1 (en) 1985-04-24
YU43198B (en) 1989-04-30
KR850000968B1 (ko) 1985-07-02
NZ206259A (en) 1986-08-08
GR79425B (da) 1984-10-22
ES543638A0 (es) 1986-01-16
FI834163A0 (fi) 1983-11-14
PT77645A (en) 1983-12-01
EP0109253A3 (en) 1984-09-12
FI72980B (fi) 1987-04-30
PH21560A (en) 1987-12-11
IE832652L (en) 1984-05-15
EG16641A (en) 1990-08-30
NO160262C (no) 1989-03-29
YU224383A (en) 1986-04-30
EP0109253B1 (en) 1987-10-14
PH19293A (en) 1986-03-04
CS241069B2 (en) 1986-03-13
ES8600327A1 (es) 1985-10-01
HUT35273A (en) 1985-06-28
JPS59104398A (ja) 1984-06-16
IL70228A (en) 1987-03-31
FI834163A (fi) 1984-05-16
JPH0140038B2 (da) 1989-08-24
YU197285A (en) 1986-08-31
SU1272996A3 (ru) 1986-11-23
AU2130983A (en) 1984-05-24
DE3374065D1 (en) 1987-11-19
AU544790B2 (en) 1985-06-13
DK518683D0 (da) 1983-11-14
NO834146L (no) 1984-05-16
YU43425B (en) 1989-06-30
DK159322B (da) 1990-10-01
PL244557A1 (en) 1985-03-26
ATE30237T1 (de) 1987-10-15
NO160262B (no) 1988-12-19
PL143281B1 (en) 1988-01-30
HU193886B (en) 1987-12-28
CA1239639A (en) 1988-07-26
DK159322C (da) 1991-02-25
GT198304062A (es) 1985-05-04
ES8604257A1 (es) 1986-01-16
IL70228A0 (en) 1984-02-29
DD216017A5 (de) 1984-11-28
ES527249A0 (es) 1985-10-01
CS845583A2 (en) 1985-07-16
ZA838460B (en) 1985-06-26
FI72980C (fi) 1987-08-10
IE56234B1 (en) 1991-05-22
PL142601B1 (en) 1987-11-30
KR840006673A (ko) 1984-12-01

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