FI834163A - Epimeriskt azahomoerytromycin, dess derivat och mellanprodukter - Google Patents

Epimeriskt azahomoerytromycin, dess derivat och mellanprodukter Download PDF

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Publication number
FI834163A
FI834163A FI834163A FI834163A FI834163A FI 834163 A FI834163 A FI 834163A FI 834163 A FI834163 A FI 834163A FI 834163 A FI834163 A FI 834163A FI 834163 A FI834163 A FI 834163A
Authority
FI
Finland
Prior art keywords
epimeriskt
azahomoerytromycin
derivat
dess
mellanprodukter
Prior art date
Application number
FI834163A
Other languages
English (en)
Other versions
FI72980C (fi
FI834163A0 (fi
FI72980B (fi
Inventor
Gene Michael Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI834163A0 publication Critical patent/FI834163A0/fi
Publication of FI834163A publication Critical patent/FI834163A/fi
Application granted granted Critical
Publication of FI72980B publication Critical patent/FI72980B/fi
Publication of FI72980C publication Critical patent/FI72980C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Developing Agents For Electrophotography (AREA)
FI834163A 1982-11-15 1983-11-14 Foerfarande foer framstaellning av 4ç-epi-9-deoxo-9a-metyl-9a-aza-9a-homoerytromycin a och dess farmaceutiskt godtagbara salter samt mellanprodukterna anvaenda i foerfarandet. FI72980C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15
US44197982 1982-11-15

Publications (4)

Publication Number Publication Date
FI834163A0 FI834163A0 (fi) 1983-11-14
FI834163A true FI834163A (fi) 1984-05-16
FI72980B FI72980B (fi) 1987-04-30
FI72980C FI72980C (fi) 1987-08-10

Family

ID=23755068

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834163A FI72980C (fi) 1982-11-15 1983-11-14 Foerfarande foer framstaellning av 4ç-epi-9-deoxo-9a-metyl-9a-aza-9a-homoerytromycin a och dess farmaceutiskt godtagbara salter samt mellanprodukterna anvaenda i foerfarandet.

Country Status (26)

Country Link
EP (1) EP0109253B1 (fi)
JP (1) JPS59104398A (fi)
KR (1) KR850000968B1 (fi)
AT (1) ATE30237T1 (fi)
AU (1) AU544790B2 (fi)
CA (1) CA1239639A (fi)
CS (1) CS241069B2 (fi)
DD (1) DD216017A5 (fi)
DE (1) DE3374065D1 (fi)
DK (1) DK159322C (fi)
EG (1) EG16641A (fi)
ES (2) ES527249A0 (fi)
FI (1) FI72980C (fi)
GR (1) GR79425B (fi)
GT (1) GT198304062A (fi)
HU (1) HU193886B (fi)
IE (1) IE56234B1 (fi)
IL (1) IL70228A (fi)
NO (1) NO160262C (fi)
NZ (1) NZ206259A (fi)
PH (2) PH19293A (fi)
PL (2) PL143281B1 (fi)
PT (1) PT77645B (fi)
SU (1) SU1272996A3 (fi)
YU (2) YU43198B (fi)
ZA (1) ZA838460B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0136831B1 (en) * 1983-09-06 1988-11-09 Pfizer Inc. Azahomoerythromycin b derivatives and intermediates thereof
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
UA27040C2 (uk) * 1987-07-09 2000-02-28 Пфайзер Інк. Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
YU149889A (en) * 1989-07-26 1991-02-28 Pliva Zagreb Process for preparing biologically active derivatives of tylozine
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) * 1991-04-10 1992-10-11 Robert R. Wilkening 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
EP0515141A1 (en) * 1991-05-20 1992-11-25 Merck & Co. Inc. Novel process for the preparation of 8A-aza-8A-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1096862C (zh) 1994-05-06 2002-12-25 辉瑞大药厂 阿齐霉素的控释剂型
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
DE60025370T2 (de) * 1999-08-24 2006-09-21 Abbott Laboratories, Abbott Park 9a-azalide mit antibakterieller wirkung
EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ATE306491T1 (de) 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
ATE399536T1 (de) 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
PT77645A (en) 1983-12-01
DK518683A (da) 1984-05-16
IL70228A (en) 1987-03-31
JPH0140038B2 (fi) 1989-08-24
ES8600327A1 (es) 1985-10-01
HU193886B (en) 1987-12-28
CS845583A2 (en) 1985-07-16
YU43198B (en) 1989-04-30
DD216017A5 (de) 1984-11-28
PH19293A (en) 1986-03-04
EG16641A (en) 1990-08-30
EP0109253A3 (en) 1984-09-12
PH21560A (en) 1987-12-11
AU544790B2 (en) 1985-06-13
AU2130983A (en) 1984-05-24
YU43425B (en) 1989-06-30
IL70228A0 (en) 1984-02-29
ZA838460B (en) 1985-06-26
KR850000968B1 (ko) 1985-07-02
ATE30237T1 (de) 1987-10-15
FI72980C (fi) 1987-08-10
CA1239639A (en) 1988-07-26
SU1272996A3 (ru) 1986-11-23
PL143281B1 (en) 1988-01-30
GR79425B (fi) 1984-10-22
NZ206259A (en) 1986-08-08
JPS59104398A (ja) 1984-06-16
KR840006673A (ko) 1984-12-01
GT198304062A (es) 1985-05-04
ES527249A0 (es) 1985-10-01
FI834163A0 (fi) 1983-11-14
IE56234B1 (en) 1991-05-22
PT77645B (en) 1986-05-12
ES543638A0 (es) 1986-01-16
NO160262C (no) 1989-03-29
DK518683D0 (da) 1983-11-14
IE832652L (en) 1984-05-15
DK159322B (da) 1990-10-01
FI72980B (fi) 1987-04-30
PL244557A1 (en) 1985-03-26
YU197285A (en) 1986-08-31
EP0109253A2 (en) 1984-05-23
PL142601B1 (en) 1987-11-30
HUT35273A (en) 1985-06-28
DE3374065D1 (en) 1987-11-19
YU224383A (en) 1986-04-30
NO834146L (no) 1984-05-16
CS241069B2 (en) 1986-03-13
ES8604257A1 (es) 1986-01-16
DK159322C (da) 1991-02-25
EP0109253B1 (en) 1987-10-14
NO160262B (no) 1988-12-19
PL250350A1 (en) 1985-04-24

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MA Patent expired

Owner name: PFIZER INC.