ES8600327A1 - Un procedimiento para la preparacion de 4"-epi-9-desoxo-9a-metil-9a-aza-9a-homoeritromicina a - Google Patents

Un procedimiento para la preparacion de 4"-epi-9-desoxo-9a-metil-9a-aza-9a-homoeritromicina a

Info

Publication number
ES8600327A1
ES8600327A1 ES527249A ES527249A ES8600327A1 ES 8600327 A1 ES8600327 A1 ES 8600327A1 ES 527249 A ES527249 A ES 527249A ES 527249 A ES527249 A ES 527249A ES 8600327 A1 ES8600327 A1 ES 8600327A1
Authority
ES
Spain
Prior art keywords
azahomoerythromycin
epimeric
derivative
intermediates therefor
erythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527249A
Other languages
English (en)
Other versions
ES527249A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES527249A0 publication Critical patent/ES527249A0/es
Publication of ES8600327A1 publication Critical patent/ES8600327A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 4L-EPI-9-DESOXO-9A-METIL-9A-AZA-9A-HOMOERITROMICINA A.CONSISTE EN METILAR LA 4L-EPI-9-DESOXO-9A-AZA-9A-HOMOERITROMICINA A CON FORMALDEHIDO EN PRESENCIA DE UN AGENTE REDUCTOR SELECCIONADO ENTRE ACIDO FORMICO, CIANOBOROHIDRURO SODICO O HIDROGENO Y UN CATALIZADOR DE METAL NOBLE, EN UN DISOLVENTE INERTE A LA REACCION, A 20-100JC PARA OBTENER UN PREPARADO DE 4L-EPI-9-DESOXO-9A-METIL-9A-AZA-9A-HOMOERITROMICINA A DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA.TIENE APLICACION CLINICO-FARMACEUTICA PARA EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS, DONDE SE EMPLEAN CANTIDADES ANTIBACTERIANAMENTE EFECTIVAS DE ELLAS E INTERMEDIOS DE LAS MISMAS, COMO ANTIBIOTICOS DE MACROLIDA, COMO ERITROMICINA A.
ES527249A 1982-11-15 1983-11-14 Un procedimiento para la preparacion de 4"-epi-9-desoxo-9a-metil-9a-aza-9a-homoeritromicina a Expired ES8600327A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44197982A 1982-11-15 1982-11-15

Publications (2)

Publication Number Publication Date
ES527249A0 ES527249A0 (es) 1985-10-01
ES8600327A1 true ES8600327A1 (es) 1985-10-01

Family

ID=23755068

Family Applications (2)

Application Number Title Priority Date Filing Date
ES527249A Expired ES8600327A1 (es) 1982-11-15 1983-11-14 Un procedimiento para la preparacion de 4"-epi-9-desoxo-9a-metil-9a-aza-9a-homoeritromicina a
ES543638A Expired ES8604257A1 (es) 1982-11-15 1985-05-29 Un procedimiento para la preparacion de 4-epi-9-desoxo-9a- metil-9a-aza-9a-homoeritromicina a

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543638A Expired ES8604257A1 (es) 1982-11-15 1985-05-29 Un procedimiento para la preparacion de 4-epi-9-desoxo-9a- metil-9a-aza-9a-homoeritromicina a

Country Status (26)

Country Link
EP (1) EP0109253B1 (es)
JP (1) JPS59104398A (es)
KR (1) KR850000968B1 (es)
AT (1) ATE30237T1 (es)
AU (1) AU544790B2 (es)
CA (1) CA1239639A (es)
CS (1) CS241069B2 (es)
DD (1) DD216017A5 (es)
DE (1) DE3374065D1 (es)
DK (1) DK159322C (es)
EG (1) EG16641A (es)
ES (2) ES8600327A1 (es)
FI (1) FI72980C (es)
GR (1) GR79425B (es)
GT (1) GT198304062A (es)
HU (1) HU193886B (es)
IE (1) IE56234B1 (es)
IL (1) IL70228A (es)
NO (1) NO160262C (es)
NZ (1) NZ206259A (es)
PH (2) PH19293A (es)
PL (2) PL142601B1 (es)
PT (1) PT77645B (es)
SU (1) SU1272996A3 (es)
YU (2) YU43198B (es)
ZA (1) ZA838460B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
SI8911498B (sl) * 1989-07-26 1998-10-31 Pliva Postopek za pripravo derivatov tilozina
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
ES2163504T5 (es) 1994-05-06 2008-05-16 Pfizer Inc. Formas de dosificacion de liberacion controlada de azitromicina.
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
BR0009101A (pt) * 1999-08-24 2002-02-05 Abbott Lab 9a-azalidas com atividade antibacteriana
CA2396426A1 (en) * 2000-01-04 2001-07-12 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
EP1313749B1 (en) 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
US6852262B2 (en) 2002-05-09 2005-02-08 The Gillette Company Insert molding razor cartridges
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2547774A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
JP2007513139A (ja) 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
JPS5788193A (en) * 1980-11-21 1982-06-01 Pliva Pharm & Chem Works 11-aza-10-deoxo-10-dihydroerythromycin a, derivatives and manufacture
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents

Also Published As

Publication number Publication date
DK159322B (da) 1990-10-01
PL244557A1 (en) 1985-03-26
DD216017A5 (de) 1984-11-28
ATE30237T1 (de) 1987-10-15
NO160262B (no) 1988-12-19
HU193886B (en) 1987-12-28
DK518683A (da) 1984-05-16
YU43198B (en) 1989-04-30
YU43425B (en) 1989-06-30
FI834163A (fi) 1984-05-16
ES543638A0 (es) 1986-01-16
IL70228A0 (en) 1984-02-29
ZA838460B (en) 1985-06-26
CA1239639A (en) 1988-07-26
KR850000968B1 (ko) 1985-07-02
PH21560A (en) 1987-12-11
AU544790B2 (en) 1985-06-13
PT77645A (en) 1983-12-01
EG16641A (en) 1990-08-30
ES527249A0 (es) 1985-10-01
FI72980C (fi) 1987-08-10
NO834146L (no) 1984-05-16
PT77645B (en) 1986-05-12
CS241069B2 (en) 1986-03-13
JPS59104398A (ja) 1984-06-16
PL142601B1 (en) 1987-11-30
DE3374065D1 (en) 1987-11-19
FI834163A0 (fi) 1983-11-14
NO160262C (no) 1989-03-29
IE832652L (en) 1984-05-15
EP0109253A3 (en) 1984-09-12
IL70228A (en) 1987-03-31
EP0109253A2 (en) 1984-05-23
AU2130983A (en) 1984-05-24
CS845583A2 (en) 1985-07-16
GR79425B (es) 1984-10-22
EP0109253B1 (en) 1987-10-14
ES8604257A1 (es) 1986-01-16
PH19293A (en) 1986-03-04
YU224383A (en) 1986-04-30
HUT35273A (en) 1985-06-28
DK518683D0 (da) 1983-11-14
NZ206259A (en) 1986-08-08
FI72980B (fi) 1987-04-30
PL143281B1 (en) 1988-01-30
IE56234B1 (en) 1991-05-22
SU1272996A3 (ru) 1986-11-23
YU197285A (en) 1986-08-31
GT198304062A (es) 1985-05-04
JPH0140038B2 (es) 1989-08-24
DK159322C (da) 1991-02-25
KR840006673A (ko) 1984-12-01
PL250350A1 (en) 1985-04-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040626