NL7705801A - Analgesic decahydro-isoquinolines - with 4A phenyl substits. - Google Patents

Analgesic decahydro-isoquinolines - with 4A phenyl substits.

Info

Publication number
NL7705801A
NL7705801A NL7705801A NL7705801A NL7705801A NL 7705801 A NL7705801 A NL 7705801A NL 7705801 A NL7705801 A NL 7705801A NL 7705801 A NL7705801 A NL 7705801A NL 7705801 A NL7705801 A NL 7705801A
Authority
NL
Netherlands
Prior art keywords
isoquinolines
decahydro
alkyl
formula
substits
Prior art date
Application number
NL7705801A
Other languages
Dutch (nl)
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to NL7705801A priority Critical patent/NL7705801A/en
Publication of NL7705801A publication Critical patent/NL7705801A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Isoquinolines of formula (I) are with their acid-addn. salts new: (where R' is H or 1-4C alkyl; R2 is H; R3 and R4 together are O; R5 and R6 are H. Or R' is H, 1-4C alkyl or 1-4C alkanoyl; R2 is 1-6C alkyl, a group of formula: (where R7 and R8 are H or 1-4C alkyl), or a group of formula (where m is 2,3, or 4), or a group of formula (where n is 1 or 2), or a group of formula: (where p is 1 or 2; R9 is H, halo, CF3, alkyl, alkoxy, NH2 or dialkylamino); R3 is H, OH or -N3; R4 is H; or R4 and R3 together are O; R5 and R6 are H; or R3 and R6 together are a bond; R4 and R5 are H; or R3 and R6 are H; R4 and R5 together are a bond; provided that n is 1 when R2 is R3 is OH; R4 is H; or R3 and R4 together are O; p is 2 when R2 is R3 is OH; R4 is H; or R3 and R4 together are O). Specifically claimed is e.g. (4aRS, 6RS, 8aRS)-6-azido-decahydro-4a-(3-hydroxyphenyl)-2-methyl-cis-isoquin- oline.
NL7705801A 1977-05-26 1977-05-26 Analgesic decahydro-isoquinolines - with 4A phenyl substits. NL7705801A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7705801A NL7705801A (en) 1977-05-26 1977-05-26 Analgesic decahydro-isoquinolines - with 4A phenyl substits.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7705801A NL7705801A (en) 1977-05-26 1977-05-26 Analgesic decahydro-isoquinolines - with 4A phenyl substits.

Publications (1)

Publication Number Publication Date
NL7705801A true NL7705801A (en) 1978-11-28

Family

ID=19828622

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7705801A NL7705801A (en) 1977-05-26 1977-05-26 Analgesic decahydro-isoquinolines - with 4A phenyl substits.

Country Status (1)

Country Link
NL (1) NL7705801A (en)

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Legal Events

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