CS271321B2 - Method of isosilybine-free silybine production - Google Patents

Method of isosilybine-free silybine production Download PDF

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Publication number
CS271321B2
CS271321B2 CS858379A CS837985A CS271321B2 CS 271321 B2 CS271321 B2 CS 271321B2 CS 858379 A CS858379 A CS 858379A CS 837985 A CS837985 A CS 837985A CS 271321 B2 CS271321 B2 CS 271321B2
Authority
CS
Czechoslovakia
Prior art keywords
weight
ethyl acetate
parts
dried
methanol
Prior art date
Application number
CS858379A
Other languages
Czech (cs)
English (en)
Other versions
CS837985A2 (en
Inventor
Rolf Dr Madaus
Klaus Dr Gorler
Hartwig Dr Soicke
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of CS837985A2 publication Critical patent/CS837985A2/cs
Publication of CS271321B2 publication Critical patent/CS271321B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L59/00—Thermal insulation in general
    • F16L59/04—Arrangements using dry fillers, e.g. using slag wool which is added to the object to be insulated by pouring, spreading, spraying or the like

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CS858379A 1984-11-22 1985-11-20 Method of isosilybine-free silybine production CS271321B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442641 1984-11-22
DE19853537656 DE3537656A1 (de) 1984-11-22 1985-10-23 Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin

Publications (2)

Publication Number Publication Date
CS837985A2 CS837985A2 (en) 1990-02-12
CS271321B2 true CS271321B2 (en) 1990-09-12

Family

ID=25826741

Family Applications (1)

Application Number Title Priority Date Filing Date
CS858379A CS271321B2 (en) 1984-11-22 1985-11-20 Method of isosilybine-free silybine production

Country Status (26)

Country Link
US (1) US4871763A (fi)
JP (1) JPH0678228B2 (fi)
AR (1) AR241268A1 (fi)
AT (1) AT391315B (fi)
BE (1) BE903694A (fi)
CA (1) CA1337125C (fi)
CH (1) CH660008A5 (fi)
CS (1) CS271321B2 (fi)
DE (1) DE3537656A1 (fi)
DK (3) DK166541B1 (fi)
EG (1) EG17710A (fi)
ES (2) ES8609312A1 (fi)
FI (1) FI84065C (fi)
FR (1) FR2573426B1 (fi)
GB (1) GB2167746B (fi)
HU (1) HU195504B (fi)
IE (1) IE59209B1 (fi)
IT (1) IT1207508B (fi)
LU (1) LU86164A1 (fi)
MX (1) MX172175B (fi)
NL (1) NL192204C (fi)
NO (1) NO160206C (fi)
PL (1) PL146889B1 (fi)
PT (1) PT81531B (fi)
SE (1) SE457957B (fi)
YU (1) YU43690B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3357383B2 (ja) * 1991-08-14 2002-12-16 昌宏 黒田 低分子化植物性組成物
DE4401902C2 (de) * 1994-01-24 2000-02-03 Madaus Ag Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
FR2719451B1 (fr) * 1994-05-04 1996-07-26 Apcis Sa Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité.
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
DE69824223T2 (de) 1997-03-19 2004-09-30 Unilever N.V. Vorrichtung zum Handhaben von Gegenständen
GB2327607B8 (en) * 1997-07-31 2005-03-30 Litton Internat Company Ltd A process for producing a herbal extract composition
DE10053384A1 (de) * 2000-10-27 2002-05-08 Bionorica Arzneimittel Gmbh Pharmazeutische Zubereitung aus Mariendistel und Terpenen
US6699900B2 (en) * 2001-04-07 2004-03-02 Jan E. Zielinski Hydrophilic and lipophilic silibinin pro-forms
DE10360954B3 (de) * 2003-12-23 2005-08-18 Esparma Gmbh Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen
BG65997B1 (bg) * 2005-03-29 2010-09-30 "Софарма" Ад Метод за получаване на силибинин
EP2219642B1 (en) * 2007-11-15 2011-09-21 Madaus GmbH Silibinin component for the treatment of hepatitis
PT2430017T (pt) * 2009-05-14 2016-10-12 Madaus Gmbh Método para a preparação de silibinina amorfa
WO2011051742A1 (en) 2009-10-28 2011-05-05 Modutech S.A. Preparation comprising amino acids and plants and its activity in the alcohol detoxification
CN103408539B (zh) * 2013-08-28 2016-04-06 天津泰阳制药有限公司 高纯度水飞蓟宾的生产方法
AU2017207867A1 (en) * 2016-01-15 2018-08-09 Universität Hamburg Flavonoide-type compounds bearing an O-rhamnosyl residue
KR20230058156A (ko) 2020-09-29 2023-05-02 무니색하 매다사니 실리범 마리아넘 식물 물질로부터 생리활성 화합물의 추출 및 이의 이용

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773932A (en) * 1968-06-01 1973-11-20 Madaus & Co Dr Method for recovering silymarin comprising polyhydroxyphenyl chromanones
DE1767666C3 (de) * 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1923082C3 (de) * 1969-05-06 1985-08-22 Dr. Madaus & Co, 5000 Koeln Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch
DE2416302B2 (de) * 1974-04-04 1978-02-02 Dr. Madaus & Co, 5000 Köln Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
BE885558A (fr) * 1980-10-07 1981-04-07 Madaus & Co Dr Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique
DE3225688A1 (de) * 1982-07-09 1984-01-12 Suschnik Matthias Dr Verfahren zur gewinnung von silymarin aus silybum marianum

Also Published As

Publication number Publication date
DK164866C (da) 1993-01-18
DK166541B1 (da) 1993-06-07
NO854657L (no) 1986-05-23
NL192204B (nl) 1996-11-01
PL256373A1 (en) 1986-12-02
US4871763A (en) 1989-10-03
IE59209B1 (en) 1994-01-26
IT1207508B (it) 1989-05-25
SE8505488D0 (sv) 1985-11-20
FI854536A0 (fi) 1985-11-18
DK172879B1 (da) 1999-09-06
NL192204C (nl) 1997-03-04
FR2573426B1 (fr) 1988-06-10
YU43690B (en) 1989-10-31
FI84065B (fi) 1991-06-28
LU86164A1 (de) 1986-03-24
ATA337285A (de) 1990-03-15
DK189491D0 (da) 1991-11-20
EG17710A (en) 1990-10-30
YU181285A (en) 1987-12-31
NO160206B (no) 1988-12-12
CH660008A5 (de) 1987-03-13
PT81531A (de) 1985-12-01
PT81531B (pt) 1987-11-11
NO160206C (no) 1989-03-22
IT8522933A0 (it) 1985-11-21
DK114592D0 (da) 1992-09-17
DK164866B (da) 1992-08-31
AR241268A1 (es) 1992-04-30
CA1337125C (en) 1995-09-26
DK537685A (da) 1986-05-23
GB2167746A (en) 1986-06-04
DE3537656C2 (fi) 1989-03-16
NL8503136A (nl) 1986-06-16
FI84065C (fi) 1991-10-10
ES549119A0 (es) 1986-09-01
DK189491A (da) 1991-11-20
ES554022A0 (es) 1987-04-01
SE8505488L (sv) 1986-05-23
FI854536A (fi) 1986-05-23
MX172175B (es) 1993-12-07
ES8609312A1 (es) 1986-09-01
HU195504B (en) 1988-05-30
DE3537656A1 (de) 1986-05-22
AT391315B (de) 1990-09-25
JPH0678228B2 (ja) 1994-10-05
SE457957B (sv) 1989-02-13
PL146889B1 (en) 1989-03-31
DK114592A (da) 1992-09-17
BE903694A (fr) 1986-05-22
FR2573426A1 (fr) 1986-05-23
ES8704482A1 (es) 1987-04-01
HUT40115A (en) 1986-11-28
GB8527809D0 (en) 1985-12-18
GB2167746B (en) 1989-01-11
IE852927L (en) 1986-05-22
JPH05271071A (ja) 1993-10-19
DK537685D0 (da) 1985-11-21
CS837985A2 (en) 1990-02-12

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