CS252480B2 - Method of 1,3-disubstituted 2-oxindoles production - Google Patents
Method of 1,3-disubstituted 2-oxindoles production Download PDFInfo
- Publication number
- CS252480B2 CS252480B2 CS85785A CS78585A CS252480B2 CS 252480 B2 CS252480 B2 CS 252480B2 CS 85785 A CS85785 A CS 85785A CS 78585 A CS78585 A CS 78585A CS 252480 B2 CS252480 B2 CS 252480B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- thienyl
- furyl
- decomposition
- cyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS858157A CS252499B2 (cs) | 1985-02-05 | 1985-11-13 | Způsob výroby 3-substituovaných 2-oxindolů |
| CS858156A CS252498B2 (cs) | 1984-06-12 | 1985-11-13 | Způsob výroby 1,3-disubstituovaných 2-oxindoiů |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57790384A | 1984-02-07 | 1984-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS78585A2 CS78585A2 (en) | 1987-01-15 |
| CS252480B2 true CS252480B2 (en) | 1987-09-17 |
Family
ID=24310612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS85785A CS252480B2 (en) | 1984-02-07 | 1985-02-05 | Method of 1,3-disubstituted 2-oxindoles production |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4658037A (pt) |
| JP (1) | JPS60248669A (pt) |
| KR (2) | KR880000433B1 (pt) |
| BG (3) | BG40963A3 (pt) |
| CS (1) | CS252480B2 (pt) |
| DD (2) | DD234417A5 (pt) |
| HU (1) | HU194166B (pt) |
| IN (1) | IN163263B (pt) |
| MW (1) | MW185A1 (pt) |
| PL (3) | PL145310B1 (pt) |
| RO (2) | RO93218B (pt) |
| YU (3) | YU43866B (pt) |
| ZA (1) | ZA85888B (pt) |
| ZM (1) | ZM785A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721712A (en) * | 1984-06-12 | 1988-01-26 | Pfizer Inc. | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4808601A (en) * | 1984-09-19 | 1989-02-28 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| HU215112B (hu) * | 1989-01-10 | 1998-12-28 | Pfizer Inc. | Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására |
| US5086186A (en) * | 1989-05-25 | 1992-02-04 | Pfizer Inc. | N-trichloroacetyl-2-oxindole-1-carboxamides |
| US4952703A (en) * | 1989-05-25 | 1990-08-28 | Pfizer Inc. | Intermediates for making 2-oxindole-1-carboxamides |
| US5298522A (en) * | 1993-01-22 | 1994-03-29 | Pfizer Inc. | 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio |
| DE69305999T2 (de) * | 1993-02-09 | 1997-03-06 | Pfizer Inc., New York, N.Y. | Oxindol 1-[n-(alkoxycarbonyl)]carboxamide und 1-[n-carboxamido]carboxamide als antiinflammatorische wirkstoffe |
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| JP2009040790A (ja) * | 2008-08-29 | 2009-02-26 | Ube Ind Ltd | ５−フルオロオキシインドールの製造法 |
| PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
| TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN103570604B (zh) * | 2012-07-21 | 2015-10-07 | 重庆圣华曦药业股份有限公司 | 齐拉西酮中间体的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3462450A (en) * | 1966-06-29 | 1969-08-19 | Merck & Co Inc | Chemical compounds |
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| US3631177A (en) * | 1967-04-18 | 1971-12-28 | Smith Kline French Lab | 3-phenacyl-2-oxoindolines |
| US3519592A (en) * | 1967-04-18 | 1970-07-07 | Smithkline Corp | Indole compounds |
| BE714717A (pt) * | 1967-05-12 | 1968-09-30 | ||
| FR7337M (pt) * | 1968-01-11 | 1969-10-13 | ||
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| US3975531A (en) * | 1973-10-02 | 1976-08-17 | A. H. Robins Company, Incorporated | 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof |
| US4221716A (en) * | 1979-02-16 | 1980-09-09 | A. H. Robins Company, Inc. | Intermediate and process for the preparation of 7-acylindolin-2-ones |
-
1985
- 1985-01-22 IN IN42/DEL/85A patent/IN163263B/en unknown
- 1985-02-04 RO RO121802A patent/RO93218B/ro unknown
- 1985-02-04 RO RO85117533A patent/RO90621A2/ro unknown
- 1985-02-05 KR KR1019850000714A patent/KR880000433B1/ko not_active IP Right Cessation
- 1985-02-05 MW MW1/85A patent/MW185A1/xx unknown
- 1985-02-05 ZM ZM7/85A patent/ZM785A1/xx unknown
- 1985-02-05 CS CS85785A patent/CS252480B2/cs unknown
- 1985-02-06 HU HU854686A patent/HU194166B/hu unknown
- 1985-02-06 BG BG068717A patent/BG40963A3/xx unknown
- 1985-02-06 DD DD85273087A patent/DD234417A5/de not_active IP Right Cessation
- 1985-02-06 BG BG072170A patent/BG44204A3/xx unknown
- 1985-02-06 JP JP60020163A patent/JPS60248669A/ja active Granted
- 1985-02-06 BG BG072172A patent/BG43865A3/xx unknown
- 1985-02-06 YU YU180/85A patent/YU43866B/xx unknown
- 1985-02-06 ZA ZA85888A patent/ZA85888B/xx unknown
- 1985-02-07 PL PL1985255465A patent/PL145310B1/pl unknown
- 1985-02-07 PL PL1985251869A patent/PL145196B1/pl unknown
- 1985-02-07 PL PL1985255466A patent/PL145230B1/pl unknown
- 1985-12-30 US US06/814,719 patent/US4658037A/en not_active Expired - Lifetime
-
1986
- 1986-04-01 DD DD86288635A patent/DD244133A5/de not_active IP Right Cessation
-
1987
- 1987-04-10 KR KR1019870003430A patent/KR880000434B1/ko not_active IP Right Cessation
- 1987-07-09 YU YU129087A patent/YU46320B/sh unknown
- 1987-10-30 YU YU1981/87A patent/YU44062B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU18085A (en) | 1988-04-30 |
| MW185A1 (en) | 1986-04-09 |
| DD244133A5 (de) | 1987-03-25 |
| PL145196B1 (en) | 1988-08-31 |
| BG40963A3 (en) | 1987-03-14 |
| ZA85888B (en) | 1986-09-24 |
| BG44204A3 (en) | 1988-10-14 |
| RO93218A (ro) | 1987-12-31 |
| IN163263B (pt) | 1988-08-27 |
| YU198187A (en) | 1988-10-31 |
| US4658037A (en) | 1987-04-14 |
| YU43866B (en) | 1989-12-31 |
| YU44062B (en) | 1990-02-28 |
| RO90621A2 (ro) | 1986-12-10 |
| BG43865A3 (en) | 1988-08-15 |
| PL145310B1 (en) | 1988-09-30 |
| PL255465A1 (en) | 1986-07-15 |
| YU129087A (en) | 1988-02-29 |
| YU46320B (sh) | 1993-05-28 |
| CS78585A2 (en) | 1987-01-15 |
| KR850005824A (ko) | 1985-09-26 |
| RO93218B (ro) | 1988-01-01 |
| HU194166B (en) | 1988-01-28 |
| JPH0413340B2 (pt) | 1992-03-09 |
| KR880000434B1 (ko) | 1988-03-24 |
| PL251869A1 (en) | 1985-12-17 |
| ZM785A1 (en) | 1985-08-22 |
| DD234417A5 (de) | 1986-04-02 |
| KR880000433B1 (ko) | 1988-03-24 |
| JPS60248669A (ja) | 1985-12-09 |
| PL145230B1 (en) | 1988-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4569942A (en) | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | |
| KR860001873B1 (ko) | 3-치환된 2-옥신돌-1-카르복스아미드의 제조방법 | |
| CS252480B2 (en) | Method of 1,3-disubstituted 2-oxindoles production | |
| EP0208510B1 (en) | 1-substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | |
| US4721712A (en) | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | |
| KR920007269B1 (ko) | 에틸렌디아민 모노아미드 유도체의 제조방법 | |
| JPH0826018B2 (ja) | アザオキシインドール誘導体 | |
| KR970011580B1 (ko) | 항알레르기 활성을 갖는 신규의 벤조티오펜 | |
| EP0153818B1 (en) | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | |
| US5607959A (en) | Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents | |
| KR860001874B1 (ko) | 2-옥스인돌-1-카복스 아미드의 제조방법 | |
| US4665194A (en) | Process for making 2-oxindole-1-carboxamides and intermediates therefor | |
| JPH02202865A (ja) | 新規α―シアノ―β―オキソプロピオンアミド | |
| US4090020A (en) | Thienothiazine derivatives | |
| PL145950B1 (en) | Method of obtaining 1,3-diacyl-2-ketoindoles | |
| CA1255657A (en) | 1,3-disubstituted 2-oxindoles as analgesic and anti- inflammatory agents | |
| CA1289556C (en) | 1- or 3-monosubstituted 2-oxindole compound intermediates useful for the production of analgesic and anti-inflammatory agents | |
| IE850288L (en) | Analgesic oxindoles. | |
| KR880002272B1 (ko) | 1-치환된 옥신돌-3-카복사마이드의 제조방법 | |
| CS252828B2 (en) | Method of n,3-disubstituted 2-oxindole-1-carboxamides production | |
| CA1253490A (en) | Process for making 2-oxindole-1-carboxamides | |
| NO178193B (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-heteroaryloksindol-3-karboksamider | |
| CS252847B2 (cs) | Způsob výroby N,3-disubstituovaných 2-oxindol-1-karboxamidů | |
| CS252498B2 (cs) | Způsob výroby 1,3-disubstituovaných 2-oxindoiů | |
| NO841217L (no) | Fremgangsmaate til fremstilling av beta-oxo-alfa-carbamoyl-pyrrolpropionitriler |