YU46320B - Postupak za dobijanje 3-supstituisanih 2-oksindola - Google Patents

Postupak za dobijanje 3-supstituisanih 2-oksindola

Info

Publication number
YU46320B
YU46320B YU129087A YU129087A YU46320B YU 46320 B YU46320 B YU 46320B YU 129087 A YU129087 A YU 129087A YU 129087 A YU129087 A YU 129087A YU 46320 B YU46320 B YU 46320B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
formula
chloro
oxindoles
substituted
Prior art date
Application number
YU129087A
Other languages
English (en)
Other versions
YU129087A (en
Inventor
S.B. Kadin
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU129087A publication Critical patent/YU129087A/xx
Publication of YU46320B publication Critical patent/YU46320B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

gde je X vodonik, 5-fluoro ili 5-hloro; Y je vodonik, 6-fluoro ili 6-hloro; i R1 je benzil, furil, tientil ili tienilmetil; pod uslovom da kada su X i Y oba vodonik, R1 nije benzil, naznač en time, što jedinjenje formule reaguje sa aktiviranim derivatom kiseline formule R1-C(=O)-OH kao što je njen hlorid, anhidrid formule R1-(C=O)-O-(C=O)-R1, R1-C(=O)-O-(C=O)-R5 i R1-(C=O)-O-(C=O)-OR6 i jednostavni alkilestri formule R1-C(=O)-OR6, gde je R5 razgranata niža alkil grupa, kao što je t-butil, a R6 je niža alkil grupa, na temperaturi od -10 C do 25В°C, u prisustvu nižeg alkanola kao rastvarača, pogodno etanola, i u prisustvu soli alkalnog metala rastvarača nižeg alkanola, pogodno natrijumetoksid. Postupak prema zahtevu 1, naznačen time, što je X 5-hloro, Y je vodonik i R1 je 2-tientil.
YU129087A 1984-02-07 1987-07-09 Postupak za dobijanje 3-supstituisanih 2-oksindola YU46320B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57790384A 1984-02-07 1984-02-07

Publications (2)

Publication Number Publication Date
YU129087A YU129087A (en) 1988-02-29
YU46320B true YU46320B (sh) 1993-05-28

Family

ID=24310612

Family Applications (3)

Application Number Title Priority Date Filing Date
YU180/85A YU43866B (en) 1984-02-07 1985-02-06 Process for obtaining 1,3-disubstituted 2-oxindoles
YU129087A YU46320B (sh) 1984-02-07 1987-07-09 Postupak za dobijanje 3-supstituisanih 2-oksindola
YU1981/87A YU44062B (en) 1984-02-07 1987-10-30 Process for obtaining 1,3-disubstituted 2-oxindols

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU180/85A YU43866B (en) 1984-02-07 1985-02-06 Process for obtaining 1,3-disubstituted 2-oxindoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU1981/87A YU44062B (en) 1984-02-07 1987-10-30 Process for obtaining 1,3-disubstituted 2-oxindols

Country Status (14)

Country Link
US (1) US4658037A (sh)
JP (1) JPS60248669A (sh)
KR (2) KR880000433B1 (sh)
BG (3) BG40963A3 (sh)
CS (1) CS252480B2 (sh)
DD (2) DD234417A5 (sh)
HU (1) HU194166B (sh)
IN (1) IN163263B (sh)
MW (1) MW185A1 (sh)
PL (3) PL145310B1 (sh)
RO (2) RO93218B (sh)
YU (3) YU43866B (sh)
ZA (1) ZA85888B (sh)
ZM (1) ZM785A1 (sh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
HU215112B (hu) * 1989-01-10 1998-12-28 Pfizer Inc. Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
US5086186A (en) * 1989-05-25 1992-02-04 Pfizer Inc. N-trichloroacetyl-2-oxindole-1-carboxamides
US4952703A (en) * 1989-05-25 1990-08-28 Pfizer Inc. Intermediates for making 2-oxindole-1-carboxamides
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
DE69305999T2 (de) * 1993-02-09 1997-03-06 Pfizer Inc., New York, N.Y. Oxindol 1-[n-(alkoxycarbonyl)]carboxamide und 1-[n-carboxamido]carboxamide als antiinflammatorische wirkstoffe
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
JP2009040790A (ja) * 2008-08-29 2009-02-26 Ube Ind Ltd ５−フルオロオキシインドールの製造法
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103570604B (zh) * 2012-07-21 2015-10-07 重庆圣华曦药业股份有限公司 齐拉西酮中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462450A (en) * 1966-06-29 1969-08-19 Merck & Co Inc Chemical compounds
GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
US3631177A (en) * 1967-04-18 1971-12-28 Smith Kline French Lab 3-phenacyl-2-oxoindolines
US3519592A (en) * 1967-04-18 1970-07-07 Smithkline Corp Indole compounds
BE714717A (sh) * 1967-05-12 1968-09-30
FR7337M (sh) * 1968-01-11 1969-10-13
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones

Also Published As

Publication number Publication date
YU18085A (en) 1988-04-30
MW185A1 (en) 1986-04-09
DD244133A5 (de) 1987-03-25
PL145196B1 (en) 1988-08-31
BG40963A3 (en) 1987-03-14
ZA85888B (en) 1986-09-24
BG44204A3 (en) 1988-10-14
RO93218A (ro) 1987-12-31
IN163263B (sh) 1988-08-27
YU198187A (en) 1988-10-31
US4658037A (en) 1987-04-14
YU43866B (en) 1989-12-31
YU44062B (en) 1990-02-28
RO90621A2 (ro) 1986-12-10
BG43865A3 (en) 1988-08-15
PL145310B1 (en) 1988-09-30
PL255465A1 (en) 1986-07-15
YU129087A (en) 1988-02-29
CS78585A2 (en) 1987-01-15
KR850005824A (ko) 1985-09-26
RO93218B (ro) 1988-01-01
HU194166B (en) 1988-01-28
JPH0413340B2 (sh) 1992-03-09
KR880000434B1 (ko) 1988-03-24
PL251869A1 (en) 1985-12-17
ZM785A1 (en) 1985-08-22
DD234417A5 (de) 1986-04-02
CS252480B2 (en) 1987-09-17
KR880000433B1 (ko) 1988-03-24
JPS60248669A (ja) 1985-12-09
PL145230B1 (en) 1988-08-31

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