BG44204A3 - Method for preparing of 2- oxyindol derivatives - Google Patents

Method for preparing of 2- oxyindol derivatives

Info

Publication number
BG44204A3
BG44204A3 BG8572170A BG7217085A BG44204A3 BG 44204 A3 BG44204 A3 BG 44204A3 BG 8572170 A BG8572170 A BG 8572170A BG 7217085 A BG7217085 A BG 7217085A BG 44204 A3 BG44204 A3 BG 44204A3
Authority
BG
Bulgaria
Prior art keywords
oxyindol
derivatives
preparing
oxyindol derivatives
Prior art date
Application number
BG8572170A
Other languages
English (en)
Inventor
Saul B Kadin
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of BG44204A3 publication Critical patent/BG44204A3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG8572170A 1984-02-07 1985-02-06 Method for preparing of 2- oxyindol derivatives BG44204A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57790384A 1984-02-07 1984-02-07

Publications (1)

Publication Number Publication Date
BG44204A3 true BG44204A3 (en) 1988-10-14

Family

ID=24310612

Family Applications (3)

Application Number Title Priority Date Filing Date
BG8568717A BG40963A3 (en) 1984-02-07 1985-02-06 Method for preparing 1, 3- disubstituted 2- oxyindols
BG8572170A BG44204A3 (en) 1984-02-07 1985-02-06 Method for preparing of 2- oxyindol derivatives
BG8572172A BG43865A3 (en) 1984-02-07 1985-02-06 Method for preparing of 1, 3- disubstituted 2- oxyindols

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG8568717A BG40963A3 (en) 1984-02-07 1985-02-06 Method for preparing 1, 3- disubstituted 2- oxyindols

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG8572172A BG43865A3 (en) 1984-02-07 1985-02-06 Method for preparing of 1, 3- disubstituted 2- oxyindols

Country Status (14)

Country Link
US (1) US4658037A (xx)
JP (1) JPS60248669A (xx)
KR (2) KR880000433B1 (xx)
BG (3) BG40963A3 (xx)
CS (1) CS252480B2 (xx)
DD (2) DD234417A5 (xx)
HU (1) HU194166B (xx)
IN (1) IN163263B (xx)
MW (1) MW185A1 (xx)
PL (3) PL145310B1 (xx)
RO (2) RO93218B (xx)
YU (3) YU43866B (xx)
ZA (1) ZA85888B (xx)
ZM (1) ZM785A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US4952703A (en) * 1989-05-25 1990-08-28 Pfizer Inc. Intermediates for making 2-oxindole-1-carboxamides
US5086186A (en) * 1989-05-25 1992-02-04 Pfizer Inc. N-trichloroacetyl-2-oxindole-1-carboxamides
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
CA2155664C (en) * 1993-02-09 1999-06-15 Ralph P. Robinson Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as antiinflammatory agents
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
JP2009040790A (ja) * 2008-08-29 2009-02-26 Ube Ind Ltd 5−フルオロオキシインドールの製造法
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103570604B (zh) * 2012-07-21 2015-10-07 重庆圣华曦药业股份有限公司 齐拉西酮中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462450A (en) * 1966-06-29 1969-08-19 Merck & Co Inc Chemical compounds
GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
US3519592A (en) * 1967-04-18 1970-07-07 Smithkline Corp Indole compounds
US3631177A (en) * 1967-04-18 1971-12-28 Smith Kline French Lab 3-phenacyl-2-oxoindolines
BE714717A (xx) * 1967-05-12 1968-09-30
FR7337M (xx) * 1968-01-11 1969-10-13
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones

Also Published As

Publication number Publication date
HU194166B (en) 1988-01-28
YU129087A (en) 1988-02-29
PL255465A1 (en) 1986-07-15
CS78585A2 (en) 1987-01-15
JPS60248669A (ja) 1985-12-09
PL145196B1 (en) 1988-08-31
PL251869A1 (en) 1985-12-17
DD244133A5 (de) 1987-03-25
ZM785A1 (en) 1985-08-22
US4658037A (en) 1987-04-14
YU43866B (en) 1989-12-31
YU46320B (sh) 1993-05-28
BG43865A3 (en) 1988-08-15
MW185A1 (en) 1986-04-09
DD234417A5 (de) 1986-04-02
KR880000434B1 (ko) 1988-03-24
BG40963A3 (en) 1987-03-14
KR850005824A (ko) 1985-09-26
RO93218B (ro) 1988-01-01
YU18085A (en) 1988-04-30
ZA85888B (en) 1986-09-24
YU44062B (en) 1990-02-28
RO93218A (ro) 1987-12-31
JPH0413340B2 (xx) 1992-03-09
CS252480B2 (en) 1987-09-17
RO90621A2 (ro) 1986-12-10
YU198187A (en) 1988-10-31
KR880000433B1 (ko) 1988-03-24
IN163263B (xx) 1988-08-27
PL145230B1 (en) 1988-08-31
PL145310B1 (en) 1988-09-30

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