CS252480B2 - Method of 1,3-disubstituted 2-oxindoles production - Google Patents

Method of 1,3-disubstituted 2-oxindoles production Download PDF

Info

Publication number
CS252480B2
CS252480B2 CS85785A CS78585A CS252480B2 CS 252480 B2 CS252480 B2 CS 252480B2 CS 85785 A CS85785 A CS 85785A CS 78585 A CS78585 A CS 78585A CS 252480 B2 CS252480 B2 CS 252480B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
thienyl
furyl
decomposition
cyclohexyl
Prior art date
Application number
CS85785A
Other languages
Czech (cs)
English (en)
Other versions
CS78585A2 (en
Inventor
Saul B Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS858157A priority Critical patent/CS252499B2/cs
Priority to CS858156A priority patent/CS252498B2/cs
Publication of CS78585A2 publication Critical patent/CS78585A2/cs
Publication of CS252480B2 publication Critical patent/CS252480B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CS85785A 1984-02-07 1985-02-05 Method of 1,3-disubstituted 2-oxindoles production CS252480B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS858157A CS252499B2 (cs) 1985-02-05 1985-11-13 Způsob výroby 3-substituovaných 2-oxindolů
CS858156A CS252498B2 (cs) 1984-06-12 1985-11-13 Způsob výroby 1,3-disubstituovaných 2-oxindoiů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57790384A 1984-02-07 1984-02-07

Publications (2)

Publication Number Publication Date
CS78585A2 CS78585A2 (en) 1987-01-15
CS252480B2 true CS252480B2 (en) 1987-09-17

Family

ID=24310612

Family Applications (1)

Application Number Title Priority Date Filing Date
CS85785A CS252480B2 (en) 1984-02-07 1985-02-05 Method of 1,3-disubstituted 2-oxindoles production

Country Status (14)

Country Link
US (1) US4658037A (nl)
JP (1) JPS60248669A (nl)
KR (2) KR880000433B1 (nl)
BG (3) BG43865A3 (nl)
CS (1) CS252480B2 (nl)
DD (2) DD234417A5 (nl)
HU (1) HU194166B (nl)
IN (1) IN163263B (nl)
MW (1) MW185A1 (nl)
PL (3) PL145230B1 (nl)
RO (2) RO90621A2 (nl)
YU (3) YU43866B (nl)
ZA (1) ZA85888B (nl)
ZM (1) ZM785A1 (nl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
HU215112B (hu) * 1989-01-10 1998-12-28 Pfizer Inc. Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
US4952703A (en) * 1989-05-25 1990-08-28 Pfizer Inc. Intermediates for making 2-oxindole-1-carboxamides
US5086186A (en) * 1989-05-25 1992-02-04 Pfizer Inc. N-trichloroacetyl-2-oxindole-1-carboxamides
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
ATE145206T1 (de) * 1993-02-09 1996-11-15 Pfizer Oxindol 1-(n-(alkoxycarbonyl)>carboxamide und 1- (n-carboxamido>carboxamide als antiinflammatorische wirkstoffe
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP2009040790A (ja) * 2008-08-29 2009-02-26 Ube Ind Ltd ５−フルオロオキシインドールの製造法
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103570604B (zh) * 2012-07-21 2015-10-07 重庆圣华曦药业股份有限公司 齐拉西酮中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462450A (en) * 1966-06-29 1969-08-19 Merck & Co Inc Chemical compounds
GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
US3519592A (en) * 1967-04-18 1970-07-07 Smithkline Corp Indole compounds
US3631177A (en) * 1967-04-18 1971-12-28 Smith Kline French Lab 3-phenacyl-2-oxoindolines
BE714717A (nl) * 1967-05-12 1968-09-30
FR7337M (nl) * 1968-01-11 1969-10-13
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones

Also Published As

Publication number Publication date
RO93218A (ro) 1987-12-31
RO90621A2 (ro) 1986-12-10
JPS60248669A (ja) 1985-12-09
PL145196B1 (en) 1988-08-31
PL145230B1 (en) 1988-08-31
US4658037A (en) 1987-04-14
PL145310B1 (en) 1988-09-30
JPH0413340B2 (nl) 1992-03-09
YU46320B (sh) 1993-05-28
CS78585A2 (en) 1987-01-15
DD244133A5 (de) 1987-03-25
IN163263B (nl) 1988-08-27
YU43866B (en) 1989-12-31
KR850005824A (ko) 1985-09-26
RO93218B (ro) 1988-01-01
KR880000433B1 (ko) 1988-03-24
BG44204A3 (en) 1988-10-14
KR880000434B1 (ko) 1988-03-24
ZM785A1 (en) 1985-08-22
YU18085A (en) 1988-04-30
YU198187A (en) 1988-10-31
YU129087A (en) 1988-02-29
PL255465A1 (en) 1986-07-15
PL251869A1 (en) 1985-12-17
BG43865A3 (en) 1988-08-15
HU194166B (en) 1988-01-28
MW185A1 (en) 1986-04-09
BG40963A3 (en) 1987-03-14
DD234417A5 (de) 1986-04-02
YU44062B (en) 1990-02-28
ZA85888B (en) 1986-09-24

Similar Documents

Publication Publication Date Title
US4569942A (en) N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
KR860001873B1 (ko) 3-치환된 2-옥신돌-1-카르복스아미드의 제조방법
CS252480B2 (en) Method of 1,3-disubstituted 2-oxindoles production
EP0208510B1 (en) 1-substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents
US4721712A (en) 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
KR920007269B1 (ko) 에틸렌디아민 모노아미드 유도체의 제조방법
JPH0826018B2 (ja) アザオキシインドール誘導体
KR970011580B1 (ko) 항알레르기 활성을 갖는 신규의 벤조티오펜
EP0153818B1 (en) 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US5607959A (en) Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents
KR860001874B1 (ko) 2-옥스인돌-1-카복스 아미드의 제조방법
KR100303377B1 (ko) 신규피롤유도체
US4665194A (en) Process for making 2-oxindole-1-carboxamides and intermediates therefor
JPH02202865A (ja) 新規α―シアノ―β―オキソプロピオンアミド
US4090020A (en) Thienothiazine derivatives
PL145950B1 (en) Method of obtaining 1,3-diacyl-2-ketoindoles
CA1255657A (en) 1,3-disubstituted 2-oxindoles as analgesic and anti- inflammatory agents
CA1289556C (en) 1- or 3-monosubstituted 2-oxindole compound intermediates useful for the production of analgesic and anti-inflammatory agents
IE850288L (en) Analgesic oxindoles.
CS252828B2 (en) Method of n,3-disubstituted 2-oxindole-1-carboxamides production
CA1253490A (en) Process for making 2-oxindole-1-carboxamides
NO178193B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-heteroaryloksindol-3-karboksamider
CS252847B2 (cs) Způsob výroby N,3-disubstituovaných 2-oxindol-1-karboxamidů
CS252498B2 (cs) Způsob výroby 1,3-disubstituovaných 2-oxindoiů
NO841217L (no) Fremgangsmaate til fremstilling av beta-oxo-alfa-carbamoyl-pyrrolpropionitriler