CS249516B2 - Method of dihydropiridines production - Google Patents
Method of dihydropiridines production Download PDFInfo
- Publication number
- CS249516B2 CS249516B2 CS839668A CS966883A CS249516B2 CS 249516 B2 CS249516 B2 CS 249516B2 CS 839668 A CS839668 A CS 839668A CS 966883 A CS966883 A CS 966883A CS 249516 B2 CS249516 B2 CS 249516B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- radical
- chloro
- formula
- sub
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/55—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS847453A CS249525B2 (cs) | 1982-12-21 | 1984-10-01 | Způsob výroby dihydropyridinů |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8236347 | 1982-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS249516B2 true CS249516B2 (en) | 1987-03-12 |
Family
ID=10535140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS839668A CS249516B2 (en) | 1982-12-21 | 1983-12-20 | Method of dihydropiridines production |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US4572908A (ru) |
| EP (1) | EP0116769B1 (ru) |
| JP (1) | JPS59118782A (ru) |
| KR (1) | KR860001921B1 (ru) |
| AT (1) | ATE26114T1 (ru) |
| AU (1) | AU546057B2 (ru) |
| CA (1) | CA1215050A (ru) |
| CS (1) | CS249516B2 (ru) |
| DD (1) | DD213920A5 (ru) |
| DE (1) | DE3370481D1 (ru) |
| DK (1) | DK586583A (ru) |
| ES (2) | ES8506633A1 (ru) |
| FI (1) | FI79104C (ru) |
| GR (1) | GR81351B (ru) |
| HU (1) | HU193275B (ru) |
| IL (1) | IL70477A (ru) |
| NO (1) | NO159272C (ru) |
| NZ (1) | NZ206614A (ru) |
| PH (1) | PH20114A (ru) |
| PL (2) | PL140069B1 (ru) |
| PT (1) | PT77842B (ru) |
| SU (2) | SU1296006A3 (ru) |
| YU (2) | YU246883A (ru) |
| ZA (1) | ZA839381B (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
| GB8331120D0 (en) * | 1983-11-22 | 1983-12-29 | Pfizer Ltd | Benzaldehyde derivatives |
| EP0164247B1 (en) * | 1984-06-07 | 1989-01-11 | Pfizer Limited | Dihydropyridines |
| GR851819B (ru) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
| GB8601382D0 (en) * | 1986-01-21 | 1986-02-26 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
| US5202330A (en) * | 1985-06-03 | 1993-04-13 | E. R. Squibb & Sons, Inc. | 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters |
| IT1204421B (it) * | 1986-06-27 | 1989-03-01 | Boehringer Biochemia Srl | 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono |
| DE3531498A1 (de) * | 1985-09-04 | 1987-03-05 | Bayer Ag | Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| US4820842A (en) * | 1986-11-19 | 1989-04-11 | Warner-Lambert Company | 2-substituted-1,4-dihydropyridines |
| IT1204948B (it) * | 1987-03-13 | 1989-03-10 | Boheringer Biochemia Robin S P | 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono. |
| US4753946A (en) * | 1987-04-08 | 1988-06-28 | E. R. Squibb & Sons, Inc. | Pyrimidinecarboxylic acid derivatives |
| GB9319341D0 (en) * | 1993-09-17 | 1993-11-03 | Wellcome Found | Novel process |
| GB9611046D0 (en) * | 1996-05-25 | 1996-07-31 | Wivenhoe Techn Ltd | Pharmacological compounds |
| ES2151850B1 (es) | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
| US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| AU2001294354A1 (en) | 2000-12-29 | 2002-07-16 | Bioorganics B.V. | Process for making amlodipine, derivatives thereof, and precursors therefor |
| WO2002053541A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amide derivative of amlodipine |
| CA2501534A1 (en) | 2002-10-07 | 2004-04-22 | Artesian Therapeutics, Inc. | Dihydropyridine compounds having simultaneous ability to block l-type calcium channels and to inhibit phosphodiesterase type 3 activity |
| EP1975167A1 (en) * | 2007-03-30 | 2008-10-01 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
| JP2010100562A (ja) * | 2008-10-23 | 2010-05-06 | Daito Kk | アムロジピン製造中間体の精製方法 |
| CN102464608B (zh) * | 2010-11-15 | 2016-05-11 | 江苏先声药物研究有限公司 | 化合物及其作为l-型钙通道阻滞剂或/和乙酰胆碱酯酶抑制剂的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4284634A (en) * | 1975-07-02 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same |
| DE2658183A1 (de) * | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
| DE2740080A1 (de) * | 1977-09-06 | 1979-03-15 | Bayer Ag | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4144343A (en) * | 1978-01-04 | 1979-03-13 | Merck & Co., Inc. | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines |
| JPS5547656A (en) * | 1978-09-29 | 1980-04-04 | Dainippon Pharmaceut Co Ltd | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
| DE2844595A1 (de) * | 1978-10-13 | 1980-04-30 | Bayer Ag | Acylaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| SE7910521L (sv) * | 1979-12-20 | 1981-06-21 | Haessle Ab | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
| DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| DE3363743D1 (en) * | 1982-07-22 | 1986-07-03 | Pfizer Ltd | Dihydropyridine anti-ischaemic and antihypertensive agents |
| EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
-
1983
- 1983-12-16 PL PL1983245158A patent/PL140069B1/pl unknown
- 1983-12-16 PT PT77842A patent/PT77842B/pt not_active IP Right Cessation
- 1983-12-16 US US06/562,482 patent/US4572908A/en not_active Expired - Lifetime
- 1983-12-16 PL PL1983250215A patent/PL140573B1/pl unknown
- 1983-12-19 IL IL70477A patent/IL70477A/xx not_active IP Right Cessation
- 1983-12-19 KR KR1019830006010A patent/KR860001921B1/ko active
- 1983-12-19 ES ES528157A patent/ES8506633A1/es not_active Expired
- 1983-12-19 NZ NZ206614A patent/NZ206614A/en unknown
- 1983-12-19 PH PH30000A patent/PH20114A/en unknown
- 1983-12-19 ZA ZA839381A patent/ZA839381B/xx unknown
- 1983-12-19 DE DE8383307719T patent/DE3370481D1/de not_active Expired
- 1983-12-19 EP EP83307719A patent/EP0116769B1/en not_active Expired
- 1983-12-19 NO NO834689A patent/NO159272C/no unknown
- 1983-12-19 AT AT83307719T patent/ATE26114T1/de not_active IP Right Cessation
- 1983-12-20 YU YU02468/83A patent/YU246883A/xx unknown
- 1983-12-20 CA CA000443770A patent/CA1215050A/en not_active Expired
- 1983-12-20 CS CS839668A patent/CS249516B2/cs unknown
- 1983-12-20 HU HU834351A patent/HU193275B/hu not_active IP Right Cessation
- 1983-12-20 DD DD83258248A patent/DD213920A5/de unknown
- 1983-12-20 DK DK586583A patent/DK586583A/da not_active Application Discontinuation
- 1983-12-20 SU SU833682597A patent/SU1296006A3/ru active
- 1983-12-20 FI FI834692A patent/FI79104C/fi not_active IP Right Cessation
- 1983-12-20 AU AU22559/83A patent/AU546057B2/en not_active Ceased
- 1983-12-20 GR GR73290A patent/GR81351B/el unknown
- 1983-12-21 JP JP58241806A patent/JPS59118782A/ja active Granted
-
1984
- 1984-05-08 SU SU843739756A patent/SU1391499A3/ru active
- 1984-07-30 ES ES534723A patent/ES8505997A1/es not_active Expired
-
1985
- 1985-11-11 YU YU01755/85A patent/YU175585A/xx unknown
-
1986
- 1986-02-14 US US06/830,292 patent/US4661485A/en not_active Expired - Lifetime
- 1986-02-14 US US06/830,384 patent/US4670449A/en not_active Expired - Lifetime
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