CS232740B2 - Method of making pyridiniumthiomethylcephalosporine derivatives - Google Patents

Method of making pyridiniumthiomethylcephalosporine derivatives Download PDF

Info

Publication number
CS232740B2
CS232740B2 CS828106A CS810682A CS232740B2 CS 232740 B2 CS232740 B2 CS 232740B2 CS 828106 A CS828106 A CS 828106A CS 810682 A CS810682 A CS 810682A CS 232740 B2 CS232740 B2 CS 232740B2
Authority
CS
Czechoslovakia
Prior art keywords
ppm
group
anion
pyridine
formula
Prior art date
Application number
CS828106A
Other languages
Czech (cs)
English (en)
Other versions
CS810682A2 (en
Inventor
Bernard Labeeuw
Ali Salhi
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Priority to CS84426A priority Critical patent/CS235998B2/cs
Publication of CS810682A2 publication Critical patent/CS810682A2/cs
Priority to CS841706A priority patent/CS236000B2/cs
Publication of CS232740B2 publication Critical patent/CS232740B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Carbon Steel Or Casting Steel Manufacturing (AREA)
CS828106A 1981-11-16 1982-11-15 Method of making pyridiniumthiomethylcephalosporine derivatives CS232740B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS84426A CS235998B2 (cs) 1981-11-16 1984-01-19 Způsob výroby nových derivátů pyridiniumthiomethylcefalosporinů
CS841706A CS236000B2 (cs) 1981-11-16 1984-03-09 Způsob přípravy nových derivátů pyridiniumthiomethylcefalosporinů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8121385A FR2516515A1 (fr) 1981-11-16 1981-11-16 Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
CS810682A2 CS810682A2 (en) 1984-02-13
CS232740B2 true CS232740B2 (en) 1985-02-14

Family

ID=9264025

Family Applications (1)

Application Number Title Priority Date Filing Date
CS828106A CS232740B2 (en) 1981-11-16 1982-11-15 Method of making pyridiniumthiomethylcephalosporine derivatives

Country Status (28)

Country Link
US (1) US4593022A (de)
EP (1) EP0088853B1 (de)
JP (1) JPS5890590A (de)
KR (1) KR880001816B1 (de)
AT (1) ATE25847T1 (de)
AU (1) AU566027B2 (de)
CA (1) CA1201432A (de)
CS (1) CS232740B2 (de)
DE (1) DE3275649D1 (de)
DK (1) DK499382A (de)
EG (1) EG15642A (de)
ES (3) ES8401082A1 (de)
FI (1) FI74710C (de)
FR (1) FR2516515A1 (de)
GR (1) GR76748B (de)
HU (1) HU187812B (de)
IE (1) IE54068B1 (de)
IL (1) IL67208A (de)
MA (1) MA19644A1 (de)
NO (1) NO823740L (de)
NZ (1) NZ202493A (de)
OA (1) OA07253A (de)
PL (3) PL136101B1 (de)
PT (1) PT75854A (de)
SG (1) SG2289G (de)
SU (3) SU1165236A3 (de)
YU (1) YU253782A (de)
ZA (1) ZA828388B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0115770B2 (de) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazolderivate
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
JPS6117589A (ja) * 1984-07-03 1986-01-25 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体及びその製造法
JPS60178890A (ja) * 1984-02-23 1985-09-12 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体およびその製造法
KR920004820B1 (ko) * 1984-02-23 1992-06-18 메이지제과 주식회사 새로운 세팔로스포린 유도체의 제조방법
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
US4761410A (en) * 1985-01-14 1988-08-02 Fujisawa Pharmaceutical Co., Ltd. Cephem Compounds
US4645769A (en) * 1985-03-01 1987-02-24 Merck & Co., Inc. 1-oxa-1-dethia-cephalosporin compounds and antibacterial agent comprising the same
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPH064645B2 (ja) * 1985-11-27 1994-01-19 明治製菓株式会社 新規セフアロスポリン誘導体およびそれを含む抗菌剤
US5359057A (en) * 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
DE3782260T2 (de) * 1986-03-20 1993-05-06 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
US4880797A (en) * 1986-03-20 1989-11-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives and antibacterial agents
JPS63154622A (ja) * 1986-12-18 1988-06-27 Meiji Seika Kaisha Ltd セフアロスポリン誘導体を有効成分とする哺乳動物用抗菌剤
WO1991005789A1 (en) * 1987-03-20 1991-05-02 Banyu Pharmaceutical Co., Ltd. 3-[(1-substituted pyridinium-4-yl)thiomethyl]-cephalosporin derivatives
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
US20120329770A1 (en) * 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2857196C3 (de) * 1977-04-19 1981-04-16 CIBA-GEIGY AG, CH 4002 Basel Verfahren zum Klotzfärben
GB1604723A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxyimino-acetamido)-cephem derivatives
GB2027691B (en) * 1978-05-26 1983-03-02 Glaxo Group Ltd Cephalosporin antibiotics
GB1604724A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxymino-acedamido)-cephem derivatives
AR229882A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
GB2036738B (en) * 1978-11-17 1983-01-19 Glaxo Group Ltd Cephalosporin antibiotics
IE49211B1 (en) * 1978-11-17 1985-08-21 Glaxo Group Ltd Cephalosporin antibiotics
ES8103101A1 (es) * 1979-03-22 1981-02-16 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
GB2046261B (en) * 1979-03-22 1983-07-20 Glaxo Group Ltd Cephalosporin antibiotics
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
EG15642A (en) 1986-09-30
FR2516515B1 (de) 1984-11-23
SU1276263A3 (ru) 1986-12-07
IL67208A (en) 1986-03-31
DE3275649D1 (en) 1987-04-16
ES526002A0 (es) 1984-06-16
SG2289G (en) 1989-06-02
GR76748B (de) 1984-08-30
ES517393A0 (es) 1983-12-01
KR880001816B1 (ko) 1988-09-19
PL244233A1 (en) 1984-06-18
ES8401082A1 (es) 1983-12-01
EP0088853A1 (de) 1983-09-21
SU1165236A3 (ru) 1985-06-30
CA1201432A (en) 1986-03-04
SU1318145A3 (ru) 1987-06-15
FI823917A0 (fi) 1982-11-16
HU187812B (en) 1986-02-28
FI823917L (fi) 1983-05-17
CS810682A2 (en) 1984-02-13
EP0088853B1 (de) 1987-03-11
DK499382A (da) 1983-05-17
KR840002407A (ko) 1984-07-21
YU253782A (en) 1984-12-31
ES8405807A1 (es) 1984-06-16
NZ202493A (en) 1985-11-08
AU9049982A (en) 1983-05-26
FI74710B (fi) 1987-11-30
IE54068B1 (en) 1989-06-07
PL239045A1 (en) 1984-02-27
PT75854A (fr) 1982-12-01
US4593022A (en) 1986-06-03
AU566027B2 (en) 1987-10-08
NO823740L (no) 1983-05-18
ZA828388B (en) 1983-10-26
ES8405806A1 (es) 1984-06-16
FI74710C (fi) 1988-03-10
IL67208A0 (en) 1983-03-31
ES526001A0 (es) 1984-06-16
PL136099B1 (en) 1986-01-31
OA07253A (fr) 1984-04-30
PL244232A1 (en) 1984-06-18
MA19644A1 (fr) 1983-07-01
JPS5890590A (ja) 1983-05-30
FR2516515A1 (fr) 1983-05-20
ATE25847T1 (de) 1987-03-15
PL136101B1 (en) 1986-01-31
IE822665L (en) 1983-05-16
PL136539B1 (en) 1986-02-28

Similar Documents

Publication Publication Date Title
CS232740B2 (en) Method of making pyridiniumthiomethylcephalosporine derivatives
PL172835B1 (pl) Chlorowodorek kwasu 7- ß -[(Z)-2-(2-amino-4-tiazolilo)-2-hydroksyiminoacetamido]-3-(1,2,3-triazol-4-ilo)-tiometylotio-3 -cefemo-4-karboksylowego oraz sposób jego wytwarzania, krystaliczny wodzian chlorowodorku kwasu 7- ß -(Z)-2-(2-amino-4-tiazolilo)-2-hydroksyiminoacetamido]-3-(1,2,3-triazol-4-ilo)-tiometylotio-3-ce- femo-4-karboksylowego oraz sposób jego wytwarzania PL PL PL PL PL
CZ2003606A3 (cs) Deriváty 3-(heteroarylacetamido)-2-oxo-azetidin-1-sulfonových kyselin jako antibakteriální činidla
CS264257B2 (en) Process for preparing new derivatives of cephalosporine
EP0154253B1 (de) 3-Substituierte Carbacephem-Verbindung und sie enthaltende pharmazeutische Zusammensetzung
US4476123A (en) Antibiotic derivatives, derived from cephalosporins with thiazolyl substituents, pharmaceutical preparations and salts thereof
CS249512B2 (en) Method of cephalosporine's derivatives preparatio
JPS63107989A (ja) セファロスポリン化合物
US4609654A (en) Derivatives of cephalosporins substituted in 3 position by a thiomethyl heterocycle group; and pharmaceutical compositions containing them
KR900003563B1 (ko) 세팔로스포린 유도체의 제조방법
CH651574A5 (de) Cephalosporinantibiotika, ihre herstellung und pharmazeutische zubereitungen.
DE3851906T2 (de) Cephalosporinverbindungen und antibakterielle Mittel.
JPH0633281B2 (ja) 新規セファロスポリン化合物及び抗菌剤
KR830001130B1 (ko) 세팔로스포린 항생제의 제조방법
US4929612A (en) Thiadiazolylacetamide cephem derivatives
KR100696422B1 (ko) 항생물질로서 사이클릭 아미노구아니딘 치환체를 가진세팔로스포린
CS236797B2 (en) Processing of new cefalosporine derivatives
CH644867A5 (de) In der 3- und 7-stellung substituierte cephemcarbonsaeuren.
AU612414B2 (en) Cephalosporin derivatives with improved pharmacokinetics, process for their preparation, pharmaceutical compositions in which they are present and synthesis intermediate
KR0154901B1 (ko) 신규 세팔로스포린계 항생제(v)
CA1330094C (en) Intermediates for preparation of cephalosporin derivatives with improved pharmacokinetics
KR0154900B1 (ko) 신규 세팔로스포린계 항생제(ii)
KR840002046B1 (ko) 세팔로스포린의 제조방법
KR0154903B1 (ko) 신규 세팔로스포린계 항생제(i)
CS236000B2 (cs) Způsob přípravy nových derivátů pyridiniumthiomethylcefalosporinů