CS216927B2 - Method of making the new aminothiazole derivatives - Google Patents

Method of making the new aminothiazole derivatives Download PDF

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Publication number
CS216927B2
CS216927B2 CS793728A CS372879A CS216927B2 CS 216927 B2 CS216927 B2 CS 216927B2 CS 793728 A CS793728 A CS 793728A CS 372879 A CS372879 A CS 372879A CS 216927 B2 CS216927 B2 CS 216927B2
Authority
CS
Czechoslovakia
Prior art keywords
phenyl
carbon atoms
hydrogen
mol
compounds
Prior art date
Application number
CS793728A
Other languages
Czech (cs)
English (en)
Inventor
Joseph G Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS216927B2 publication Critical patent/CS216927B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B15/00—Nails; Staples
    • F16B15/0023—Nail plates
    • F16B2015/0076—Nail plates with provisions for additional fastening means, e.g. hooks, holes for separate screws or nails, adhesive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS793728A 1978-06-02 1979-05-30 Method of making the new aminothiazole derivatives CS216927B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91183078A 1978-06-02 1978-06-02

Publications (1)

Publication Number Publication Date
CS216927B2 true CS216927B2 (en) 1982-12-31

Family

ID=25430923

Family Applications (1)

Application Number Title Priority Date Filing Date
CS793728A CS216927B2 (en) 1978-06-02 1979-05-30 Method of making the new aminothiazole derivatives

Country Status (36)

Country Link
JP (1) JPS5936988B2 (it)
AR (1) AR226285A1 (it)
AT (1) AT373248B (it)
AU (1) AU511242B2 (it)
BE (1) BE876732A (it)
CA (1) CA1117949A (it)
CH (1) CH639653A5 (it)
CS (1) CS216927B2 (it)
DD (1) DD144055A5 (it)
DE (1) DE2922523C2 (it)
DK (1) DK150068C (it)
EG (1) EG14354A (it)
ES (1) ES481220A1 (it)
FI (1) FI68820C (it)
FR (1) FR2427333A1 (it)
GB (1) GB2022085B (it)
GR (1) GR73142B (it)
HK (1) HK66487A (it)
HU (1) HU180045B (it)
IE (1) IE48426B1 (it)
IL (1) IL57450A (it)
IT (1) IT1121238B (it)
KE (1) KE3459A (it)
LU (1) LU81349A1 (it)
MY (1) MY8500318A (it)
NL (1) NL178421C (it)
NO (1) NO150760C (it)
NZ (1) NZ190623A (it)
PH (1) PH17020A (it)
PL (1) PL117515B1 (it)
PT (1) PT69718A (it)
SE (1) SE438333B (it)
SG (1) SG56184G (it)
SU (1) SU843746A3 (it)
YU (1) YU40997B (it)
ZA (1) ZA792729B (it)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57501565A (it) * 1980-10-24 1982-09-02
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
WO1982002384A1 (en) * 1981-01-08 1982-07-22 Sakano Isao Their preparation,and medicinal composition containing same
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
DE3273781D1 (en) * 1981-01-13 1986-11-20 Mitsui Toatsu Chemicals Novel thiazole compounds, process for their preparation, and medicinal composition containing same
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3227329A1 (de) * 1982-07-22 1984-01-26 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-n,n-disubstituierten aminothiazolen
WO1986003203A1 (en) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienylthiazole derivatives
FR2581063B1 (fr) * 1985-04-30 1987-07-17 Chauvin Blache Lab Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
JPS63152368A (ja) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd 新規なアミノアゾ−ル誘導体およびその酸付加塩
JPH075579B2 (ja) * 1986-09-01 1995-01-25 吉富製薬株式会社 アミノチアゾ−ル化合物
JPH0753666B2 (ja) * 1987-09-14 1995-06-07 久光製薬株式会社 置換ジフェニルチアゾール誘導体からなる抗炎症剤
EP0486543B1 (en) * 1989-08-10 1997-10-22 Commonwealth Scientific And Industrial Research Organisation Method for producing an electrosuspension of micronised particles
WO1992015570A1 (fr) * 1991-03-07 1992-09-17 Hisamitsu Pharmaceutical Co., Inc. Nouveau derive de diphenylthiazole
FR2692893B1 (fr) * 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
EP0772606A1 (en) * 1994-07-27 1997-05-14 G.D. SEARLE & CO. Substituted thiazoles for the treatment of inflammation
FR2754258B1 (fr) 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
WO2003015777A1 (en) * 2001-08-13 2003-02-27 Lion Bioscience Ag Nr1h4 nuclear receptor binding compounds
CA2461360A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
NZ533994A (en) 2002-01-11 2006-10-27 Sankyo Co Amino alcohol derivative or phosphonic acid derivative and medicinal compostion containing these
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
NZ549162A (en) 2004-02-24 2009-12-24 Sankyo Co Amino-pyrrol alcohol compounds
KR20080019213A (ko) * 2005-05-09 2008-03-03 아칠리온 파르마세우티칼스 인코포레이티드 티아졸 화합물 및 그 사용방법
MY149143A (en) 2006-01-18 2013-07-15 Amgen Inc Thiazole compounds as protien kinase b (pkb) inhibitors
WO2009011871A2 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20130143927A1 (en) * 2011-06-10 2013-06-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN110590785B (zh) * 2019-09-23 2021-02-02 武汉大学 一种氨基噻唑类化合物及其制备方法与抗肠道病毒71型的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458526A (en) * 1966-09-26 1969-07-29 Upjohn Co Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles

Also Published As

Publication number Publication date
SE438333B (sv) 1985-04-15
SU843746A3 (ru) 1981-06-30
FR2427333B1 (it) 1983-05-20
IL57450A0 (en) 1979-09-30
ATA401679A (de) 1983-05-15
AR226285A1 (es) 1982-06-30
GR73142B (it) 1984-02-09
IT1121238B (it) 1986-03-26
IL57450A (en) 1982-11-30
SE7904798L (sv) 1979-12-03
GB2022085B (en) 1983-01-12
FR2427333A1 (fr) 1979-12-28
JPS5936988B2 (ja) 1984-09-06
NO150760C (no) 1984-12-12
DK150068C (da) 1987-06-29
NL178421C (nl) 1986-03-17
PH17020A (en) 1984-05-11
FI68820B (fi) 1985-07-31
JPS54160369A (en) 1979-12-19
CH639653A5 (fr) 1983-11-30
NO150760B (no) 1984-09-03
LU81349A1 (fr) 1979-12-07
KE3459A (en) 1984-10-12
NO791831L (no) 1979-12-04
ZA792729B (en) 1981-03-25
DD144055A5 (de) 1980-09-24
PL216030A1 (it) 1980-03-10
ES481220A1 (es) 1980-09-01
NL178421B (nl) 1985-10-16
EG14354A (en) 1984-06-30
PL117515B1 (en) 1981-08-31
PT69718A (en) 1979-07-01
DE2922523C2 (de) 1982-10-21
FI791754A7 (fi) 1979-11-26
DE2922523A1 (de) 1979-12-06
GB2022085A (en) 1979-12-12
NZ190623A (en) 1984-07-06
YU40997B (en) 1986-10-31
IE791069L (en) 1979-12-02
YU128879A (en) 1982-10-31
CA1117949A (en) 1982-02-09
AU511242B2 (en) 1980-08-07
AT373248B (de) 1983-12-27
HU180045B (en) 1983-01-28
IE48426B1 (en) 1985-01-23
SG56184G (en) 1985-03-08
BE876732A (fr) 1979-12-03
HK66487A (en) 1987-09-25
MY8500318A (en) 1985-12-31
AU4763479A (en) 1979-12-06
NL7904337A (nl) 1979-12-04
DK177679A (da) 1979-12-03
IT7923228A0 (it) 1979-06-01
DK150068B (da) 1986-12-01
FI68820C (fi) 1985-11-11

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