CS201013B2 - Process for preparing new analoges of angiotensine - Google Patents
Process for preparing new analoges of angiotensine Download PDFInfo
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- CS201013B2 CS201013B2 CS784757A CS475778A CS201013B2 CS 201013 B2 CS201013 B2 CS 201013B2 CS 784757 A CS784757 A CS 784757A CS 475778 A CS475778 A CS 475778A CS 201013 B2 CS201013 B2 CS 201013B2
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- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000005053 lamin Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- VXSZRLNZRUBXJG-UHFFFAOYSA-N n',n'-diaminoethane-1,2-diamine Chemical compound NCCN(N)N VXSZRLNZRUBXJG-UHFFFAOYSA-N 0.000 description 1
- NYIODHFKZFKMSU-UHFFFAOYSA-N n,n-bis(methylamino)ethanamine Chemical compound CCN(NC)NC NYIODHFKZFKMSU-UHFFFAOYSA-N 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 235000005806 ruta Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 125000005624 silicic acid group Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 125000001239 threonyl group Chemical group 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 229960003732 tyramine Drugs 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU77RI641A HU177134B (en) | 1977-07-18 | 1977-07-18 | Process for preparing angiotensin ii analogues containing alpha-hydroxy-acid in position 1 with angiotensin ii antagonist activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS201013B2 true CS201013B2 (en) | 1980-10-31 |
Family
ID=11001038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS784757A CS201013B2 (en) | 1977-07-18 | 1978-07-17 | Process for preparing new analoges of angiotensine |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4209442A (de) |
| JP (1) | JPS5831337B2 (de) |
| AT (1) | AT360678B (de) |
| AU (1) | AU520176B2 (de) |
| BE (1) | BE869076A (de) |
| CA (1) | CA1114810A (de) |
| CH (1) | CH637916A5 (de) |
| CS (1) | CS201013B2 (de) |
| DD (1) | DD137221A5 (de) |
| DE (1) | DE2831271C2 (de) |
| DK (1) | DK319578A (de) |
| ES (1) | ES471791A1 (de) |
| FI (1) | FI64797C (de) |
| FR (1) | FR2398049A1 (de) |
| GB (1) | GB2002779B (de) |
| HU (1) | HU177134B (de) |
| IL (1) | IL55075A (de) |
| IN (1) | IN149852B (de) |
| NL (1) | NL7807627A (de) |
| NO (1) | NO148070C (de) |
| PL (1) | PL111964B1 (de) |
| SE (1) | SE444439B (de) |
| SU (1) | SU913940A3 (de) |
| YU (1) | YU41315B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2905502C2 (de) * | 1979-02-14 | 1982-07-15 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von LH-RH bzw. LH-RH-Analoga und Pyroglutamyl-N↑i↑m↑-dinitrophenyl-histidin |
| HU181008B (en) * | 1980-01-18 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing angiotenzin-ii analogues of antagonistic activity containing sarcosyl-group at the 1-positon,and an alpha-hydroxy-carboxylic acid at the 8-position |
| HU181009B (en) * | 1980-01-18 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for preparing angiotensin-ii analogues with antagonictic activity containing in position 1 sarcosyl,hydroxyacetyl or l-alpha-aminoxy-propionyl group and in positiona 8 esteric group |
| FR2546163B1 (fr) * | 1983-05-16 | 1987-10-09 | Centre Nat Rech Scient | Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application |
| HU191961B (en) * | 1984-08-02 | 1987-04-28 | Richter Gedeon Vegyeszet | Process for producing 1,5 and 8 substituted peptides of angiotenzin-ii antagonistic activity |
| US5182264A (en) * | 1986-03-07 | 1993-01-26 | Schering Corporation | Angiotensin II receptor blockers as antiglaucoma agents |
| US4772684A (en) * | 1987-01-20 | 1988-09-20 | Triton Biosciences, Inc. | Peptides affecting blood pressure regulation |
| US7012066B2 (en) * | 2000-07-21 | 2006-03-14 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886134A (en) * | 1970-03-09 | 1975-05-27 | Morton Norwich Products Inc | Analogues of angiotensin II |
| GB1320104A (en) * | 1971-05-20 | 1973-06-13 | Norwich Pharma Co | Hepta-and octapeptides |
| US3907762A (en) * | 1971-12-27 | 1975-09-23 | Univ Sherbrooke | Angiotensin{hd II {B position 8 analogs |
| DE2323322A1 (de) * | 1973-05-09 | 1974-11-28 | Hoechst Ag | Neue peptide mit blutdrucksenkender wirkung und verfahren zu ihrer herstellung |
| US3923771A (en) * | 1974-05-10 | 1975-12-02 | Francis Merlin Bumpus | N-Guanidylacetyl-{8 des-asp{hu 1{b -Ile{hu 8{b {9 {0 angiotensin II as an angiotensin antagonist |
-
1977
- 1977-07-18 HU HU77RI641A patent/HU177134B/hu not_active IP Right Cessation
-
1978
- 1978-07-04 IL IL55075A patent/IL55075A/xx unknown
- 1978-07-10 IN IN760/CAL/78A patent/IN149852B/en unknown
- 1978-07-11 FI FI782216A patent/FI64797C/fi not_active IP Right Cessation
- 1978-07-11 US US05/923,663 patent/US4209442A/en not_active Expired - Lifetime
- 1978-07-13 FR FR7821045A patent/FR2398049A1/fr active Granted
- 1978-07-13 SE SE7807824A patent/SE444439B/sv not_active IP Right Cessation
- 1978-07-13 AU AU38009/78A patent/AU520176B2/en not_active Expired
- 1978-07-17 NO NO782464A patent/NO148070C/no unknown
- 1978-07-17 YU YU1715/78A patent/YU41315B/xx unknown
- 1978-07-17 ES ES471791A patent/ES471791A1/es not_active Expired
- 1978-07-17 DD DD78206762A patent/DD137221A5/de unknown
- 1978-07-17 DK DK319578A patent/DK319578A/da not_active Application Discontinuation
- 1978-07-17 SU SU782639848A patent/SU913940A3/ru active
- 1978-07-17 CA CA307,496A patent/CA1114810A/en not_active Expired
- 1978-07-17 NL NL7807627A patent/NL7807627A/xx not_active Application Discontinuation
- 1978-07-17 GB GB7830046A patent/GB2002779B/en not_active Expired
- 1978-07-17 CH CH771878A patent/CH637916A5/de not_active IP Right Cessation
- 1978-07-17 CS CS784757A patent/CS201013B2/cs unknown
- 1978-07-17 DE DE2831271A patent/DE2831271C2/de not_active Expired
- 1978-07-18 BE BE189342A patent/BE869076A/xx not_active IP Right Cessation
- 1978-07-18 JP JP53087646A patent/JPS5831337B2/ja not_active Expired
- 1978-07-18 AT AT518378A patent/AT360678B/de active
- 1978-07-18 PL PL1978208497A patent/PL111964B1/pl unknown
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