CR7884A - Inhibidores benzamidicos del receptor p2x7 - Google Patents

Inhibidores benzamidicos del receptor p2x7

Info

Publication number
CR7884A
CR7884A CR7884A CR7884A CR7884A CR 7884 A CR7884 A CR 7884A CR 7884 A CR7884 A CR 7884A CR 7884 A CR7884 A CR 7884A CR 7884 A CR7884 A CR 7884A
Authority
CR
Costa Rica
Prior art keywords
inhibitors
benzamid
receiver
disorders
copd
Prior art date
Application number
CR7884A
Other languages
English (en)
Spanish (es)
Inventor
Anthony Dombroski Mark
Jacob Duplantier Allen
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR7884A publication Critical patent/CR7884A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
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  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
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CR7884A 2002-12-31 2005-06-23 Inhibidores benzamidicos del receptor p2x7 CR7884A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43750502P 2002-12-31 2002-12-31

Publications (1)

Publication Number Publication Date
CR7884A true CR7884A (es) 2005-08-05

Family

ID=32682427

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7884A CR7884A (es) 2002-12-31 2005-06-23 Inhibidores benzamidicos del receptor p2x7

Country Status (40)

Country Link
US (4) US6974812B2 (enExample)
EP (1) EP1581232B1 (enExample)
JP (1) JP4560411B2 (enExample)
KR (1) KR100689138B1 (enExample)
CN (1) CN1732006A (enExample)
AP (1) AP1997A (enExample)
AR (1) AR042673A1 (enExample)
AU (1) AU2003285716B2 (enExample)
BR (1) BR0317803A (enExample)
CA (1) CA2512193C (enExample)
CL (1) CL2003002765A1 (enExample)
CO (1) CO5580749A2 (enExample)
CR (1) CR7884A (enExample)
DO (1) DOP2003000790A (enExample)
EA (1) EA008591B1 (enExample)
EC (1) ECSP055884A (enExample)
ES (1) ES2464350T3 (enExample)
GE (1) GEP20084304B (enExample)
GT (1) GT200300297A (enExample)
HR (1) HRP20050609A2 (enExample)
IL (2) IL168513A (enExample)
IS (1) IS7840A (enExample)
MA (1) MA27575A1 (enExample)
MX (1) MXPA05006749A (enExample)
MY (1) MY141984A (enExample)
NI (1) NI200500118A (enExample)
NL (1) NL1025148C2 (enExample)
NO (1) NO20053587L (enExample)
NZ (1) NZ539913A (enExample)
OA (1) OA12978A (enExample)
PA (1) PA8591801A1 (enExample)
PE (1) PE20040802A1 (enExample)
PL (1) PL378251A1 (enExample)
RS (1) RS20050490A (enExample)
TN (1) TNSN05174A1 (enExample)
TW (1) TWI288133B (enExample)
UA (1) UA82346C2 (enExample)
UY (1) UY28153A1 (enExample)
WO (1) WO2004058270A1 (enExample)
ZA (1) ZA200503912B (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
EP1837330B1 (en) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
ATE355273T1 (de) 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
RU2006146675A (ru) 2004-06-29 2008-07-10 Пфайзер Продактс Инк. (Us) Способ получения производных 5-[4-(2-гидроксипропил)-3,5-диоксо-4,5-дигидро-3н-[1,2,4] триазин-2-ил] бензамида снятием защиты с промежуточных продуктов, содержащих защищенный гидроксил
JP2008504363A (ja) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐ２ｘ７受容体のベンズアミド阻害剤を利用する併用療法
BRPI0512651A (pt) * 2004-06-29 2008-03-25 Pfizer Prod Inc método para a preparação de derivados de 5-4-(2-hidroxietil)-3,5-dioxo-4,5 dihidro-3h-1,2,4-trizin-2-ila com atividade inibidora de p2x7 por reaçaõ do derivado não substituìdo na posição 4 da trizina com um oxirano na presença de um ácido de lewis
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