BR112014005786A2 - antagonistas do receptor do tipo toll 3 para o tratamento de doenças metabólicas e cardiovasculares - Google Patents
antagonistas do receptor do tipo toll 3 para o tratamento de doenças metabólicas e cardiovascularesInfo
- Publication number
- BR112014005786A2 BR112014005786A2 BR112014005786A BR112014005786A BR112014005786A2 BR 112014005786 A2 BR112014005786 A2 BR 112014005786A2 BR 112014005786 A BR112014005786 A BR 112014005786A BR 112014005786 A BR112014005786 A BR 112014005786A BR 112014005786 A2 BR112014005786 A2 BR 112014005786A2
- Authority
- BR
- Brazil
- Prior art keywords
- toll
- metabolic
- treatment
- cardiovascular diseases
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
abstract toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases toll like receptor 3 (tlr3) antibody antagonists, polynucleotides encoding tlr3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed. ******************************************************** tradução do resumo resumo patente de invenção "antagonistas do receptor do tipo toll 3 para o tratamento de doenças metabólicas e cardiovasculares". a presente invenção refere-se a antagonistas de anticorpos do receptor tipo toll 3 (tlr3), polinucleotídeos que codificam os antagonistas de anticorpos tlr3 ou fragmentos dos mesmos, e a métodos para produzir e usar o supracitado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/051202 WO2013039471A1 (en) | 2011-09-12 | 2011-09-12 | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014005786A2 true BR112014005786A2 (pt) | 2017-03-28 |
Family
ID=47883555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014005786A BR112014005786A2 (pt) | 2011-09-12 | 2011-09-12 | antagonistas do receptor do tipo toll 3 para o tratamento de doenças metabólicas e cardiovasculares |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2755685A4 (pt) |
JP (1) | JP2014526464A (pt) |
KR (1) | KR20140075708A (pt) |
CN (1) | CN104159610A (pt) |
BR (1) | BR112014005786A2 (pt) |
CA (1) | CA2855955A1 (pt) |
EA (1) | EA201490623A1 (pt) |
IL (1) | IL231413A0 (pt) |
MX (1) | MX362457B (pt) |
NZ (1) | NZ622260A (pt) |
WO (1) | WO2013039471A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10370451B2 (en) * | 2013-04-22 | 2019-08-06 | The University Of Tokyo | Preventive or therapeutic agent for inflammatory disease |
WO2015016282A1 (ja) * | 2013-07-30 | 2015-02-05 | 国立大学法人東京大学 | 放射線誘導性消化管症候群の予防又は治療用医薬組成物 |
EP4074730A1 (en) | 2015-06-24 | 2022-10-19 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies with tailored affinity |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
DE69621940T2 (de) | 1995-08-18 | 2003-01-16 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
CN101415438B (zh) * | 2004-11-30 | 2013-03-27 | 森托科尔公司 | Toll样受体3拮抗剂、方法和用途 |
AR051836A1 (es) | 2004-11-30 | 2007-02-14 | Centocor Inc | Antagonistas de receptor 3 simil toll metodos y usos |
EP2155889A4 (en) * | 2007-05-25 | 2010-06-16 | Centocor Ortho Biotech Inc | TOLL RECEPTOR 3 MODULATORS AND USES THEREOF |
US8895263B2 (en) * | 2008-10-02 | 2014-11-25 | Janssen Biotech, Inc. | Methods for suppressing toll-like receptor activity |
WO2010045340A1 (en) | 2008-10-14 | 2010-04-22 | Centocor Ortho Biotech Inc. | Methods of humanizing and affinity-maturing antibodies |
CN105601742A (zh) * | 2008-10-31 | 2016-05-25 | 詹森生物科技公司 | Toll样受体3拮抗剂 |
MX2011011623A (es) * | 2009-04-29 | 2011-11-18 | Janssen Biotech Inc | Antagonistas del receptor tipo toll 3. |
-
2011
- 2011-09-12 KR KR1020147009316A patent/KR20140075708A/ko not_active Application Discontinuation
- 2011-09-12 NZ NZ622260A patent/NZ622260A/en not_active IP Right Cessation
- 2011-09-12 CN CN201180074797.4A patent/CN104159610A/zh active Pending
- 2011-09-12 EA EA201490623A patent/EA201490623A1/ru unknown
- 2011-09-12 JP JP2014529662A patent/JP2014526464A/ja active Pending
- 2011-09-12 WO PCT/US2011/051202 patent/WO2013039471A1/en active Application Filing
- 2011-09-12 BR BR112014005786A patent/BR112014005786A2/pt not_active Application Discontinuation
- 2011-09-12 CA CA2855955A patent/CA2855955A1/en not_active Abandoned
- 2011-09-12 MX MX2014002982A patent/MX362457B/es active IP Right Grant
- 2011-09-12 EP EP11872271.9A patent/EP2755685A4/en not_active Ceased
-
2014
- 2014-03-09 IL IL231413A patent/IL231413A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2855955A1 (en) | 2013-03-21 |
EP2755685A4 (en) | 2015-07-01 |
MX2014002982A (es) | 2015-07-06 |
IL231413A0 (en) | 2014-04-30 |
EA201490623A1 (ru) | 2016-01-29 |
WO2013039471A1 (en) | 2013-03-21 |
JP2014526464A (ja) | 2014-10-06 |
KR20140075708A (ko) | 2014-06-19 |
NZ622260A (en) | 2016-11-25 |
MX362457B (es) | 2019-01-18 |
EP2755685A1 (en) | 2014-07-23 |
CN104159610A (zh) | 2014-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.20 NA RPI NO 2532 DE 16/07/2019 POR TER SIDO INDEVIDA. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |