NZ622260A - Toll-like receptor 3 antagonists - Google Patents
Toll-like receptor 3 antagonistsInfo
- Publication number
- NZ622260A NZ622260A NZ622260A NZ62226011A NZ622260A NZ 622260 A NZ622260 A NZ 622260A NZ 622260 A NZ622260 A NZ 622260A NZ 62226011 A NZ62226011 A NZ 62226011A NZ 622260 A NZ622260 A NZ 622260A
- Authority
- NZ
- New Zealand
- Prior art keywords
- toll
- receptor
- antagonists
- cholesterol
- ldl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed is a method of lowering levels of fat accumulation, low density lipoprotein (LDL), or cholesterol; or treating cardiovascular disease by lowering LDL/cholesterol, comprising administering a therapeutically effective amount of an isolated antibody reactive with TLR3 (Toll-Like Receptor 3)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/051202 WO2013039471A1 (en) | 2011-09-12 | 2011-09-12 | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ622260A true NZ622260A (en) | 2016-11-25 |
Family
ID=47883555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ622260A NZ622260A (en) | 2011-09-12 | 2011-09-12 | Toll-like receptor 3 antagonists |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2755685A4 (en) |
JP (1) | JP2014526464A (en) |
KR (1) | KR20140075708A (en) |
CN (1) | CN104159610A (en) |
BR (1) | BR112014005786A2 (en) |
CA (1) | CA2855955A1 (en) |
EA (1) | EA201490623A1 (en) |
IL (1) | IL231413A0 (en) |
MX (1) | MX362457B (en) |
NZ (1) | NZ622260A (en) |
WO (1) | WO2013039471A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6366195B2 (en) * | 2013-04-22 | 2018-08-01 | 国立大学法人 東京大学 | Preventive or therapeutic agent for inflammatory diseases |
WO2015016282A1 (en) * | 2013-07-30 | 2015-02-05 | 国立大学法人東京大学 | Pharmaceutical composition for preventing or treating radiation-induced gastrointestinal syndrome |
CA2985718A1 (en) | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Anti-transferrin receptor antibodies with tailored affinity |
PE20231655A1 (en) | 2015-10-02 | 2023-10-17 | Hoffmann La Roche | BISPECIFIC ANTIBODIES AGAINST HUMAN CD20 AND THE HUMAN TRANSFERRIN RECEPTOR AND METHODS OF USE |
AR106189A1 (en) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
CN101415438B (en) * | 2004-11-30 | 2013-03-27 | 森托科尔公司 | TOLL like receptor 3 antagonists, methods and uses |
AR051836A1 (en) | 2004-11-30 | 2007-02-14 | Centocor Inc | RECEIVER ANTAGONISTS 3 SIMIL TOLL METHODS AND USES |
JP2010527633A (en) * | 2007-05-25 | 2010-08-19 | セントコア・オーソ・バイオテツク・インコーポレーテツド | Toll-like receptor 3 modulator and use thereof |
US8895263B2 (en) * | 2008-10-02 | 2014-11-25 | Janssen Biotech, Inc. | Methods for suppressing toll-like receptor activity |
WO2010045340A1 (en) | 2008-10-14 | 2010-04-22 | Centocor Ortho Biotech Inc. | Methods of humanizing and affinity-maturing antibodies |
LT2350304T (en) * | 2008-10-31 | 2017-02-10 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
SI2425008T1 (en) * | 2009-04-29 | 2015-12-31 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
-
2011
- 2011-09-12 KR KR1020147009316A patent/KR20140075708A/en not_active Application Discontinuation
- 2011-09-12 EA EA201490623A patent/EA201490623A1/en unknown
- 2011-09-12 CN CN201180074797.4A patent/CN104159610A/en active Pending
- 2011-09-12 MX MX2014002982A patent/MX362457B/en active IP Right Grant
- 2011-09-12 NZ NZ622260A patent/NZ622260A/en not_active IP Right Cessation
- 2011-09-12 CA CA2855955A patent/CA2855955A1/en not_active Abandoned
- 2011-09-12 BR BR112014005786A patent/BR112014005786A2/en not_active Application Discontinuation
- 2011-09-12 WO PCT/US2011/051202 patent/WO2013039471A1/en active Application Filing
- 2011-09-12 EP EP11872271.9A patent/EP2755685A4/en not_active Ceased
- 2011-09-12 JP JP2014529662A patent/JP2014526464A/en active Pending
-
2014
- 2014-03-09 IL IL231413A patent/IL231413A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112014005786A2 (en) | 2017-03-28 |
IL231413A0 (en) | 2014-04-30 |
CN104159610A (en) | 2014-11-19 |
WO2013039471A1 (en) | 2013-03-21 |
JP2014526464A (en) | 2014-10-06 |
EP2755685A1 (en) | 2014-07-23 |
KR20140075708A (en) | 2014-06-19 |
MX362457B (en) | 2019-01-18 |
EP2755685A4 (en) | 2015-07-01 |
EA201490623A1 (en) | 2016-01-29 |
CA2855955A1 (en) | 2013-03-21 |
MX2014002982A (en) | 2015-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 12 SEP 2018 BY AJ PARK Effective date: 20170620 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 12 SEP 2019 BY CPA GLOBAL Effective date: 20180823 |
|
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 12 SEP 2020 BY CPA GLOBAL Effective date: 20190801 |
|
LAPS | Patent lapsed |