TWI288133B - Benzamide inhibitors of the P2X7 receptor - Google Patents

Benzamide inhibitors of the P2X7 receptor Download PDF

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Publication number
TWI288133B
TWI288133B TW092137490A TW92137490A TWI288133B TW I288133 B TWI288133 B TW I288133B TW 092137490 A TW092137490 A TW 092137490A TW 92137490 A TW92137490 A TW 92137490A TW I288133 B TWI288133 B TW I288133B
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TW
Taiwan
Prior art keywords
dioxo
benzamide
hydroxy
dihydro
group
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Application number
TW092137490A
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English (en)
Chinese (zh)
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TW200413336A (en
Inventor
Mark Anthony Dombroski
Allen Jacob Duplantier
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Pfizer Prod Inc
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Publication of TW200413336A publication Critical patent/TW200413336A/zh
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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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TW092137490A 2002-12-31 2003-12-30 Benzamide inhibitors of the P2X7 receptor TWI288133B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43750502P 2002-12-31 2002-12-31

Publications (2)

Publication Number Publication Date
TW200413336A TW200413336A (en) 2004-08-01
TWI288133B true TWI288133B (en) 2007-10-11

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TW092137490A TWI288133B (en) 2002-12-31 2003-12-30 Benzamide inhibitors of the P2X7 receptor

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US (4) US6974812B2 (enExample)
EP (1) EP1581232B1 (enExample)
JP (1) JP4560411B2 (enExample)
KR (1) KR100689138B1 (enExample)
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AP (1) AP1997A (enExample)
AR (1) AR042673A1 (enExample)
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Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
EP1837330B1 (en) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
ATE355273T1 (de) 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
RU2006146675A (ru) 2004-06-29 2008-07-10 Пфайзер Продактс Инк. (Us) Способ получения производных 5-[4-(2-гидроксипропил)-3,5-диоксо-4,5-дигидро-3н-[1,2,4] триазин-2-ил] бензамида снятием защиты с промежуточных продуктов, содержащих защищенный гидроксил
JP2008504363A (ja) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐ２ｘ７受容体のベンズアミド阻害剤を利用する併用療法
BRPI0512651A (pt) * 2004-06-29 2008-03-25 Pfizer Prod Inc método para a preparação de derivados de 5-4-(2-hidroxietil)-3,5-dioxo-4,5 dihidro-3h-1,2,4-trizin-2-ila com atividade inibidora de p2x7 por reaçaõ do derivado não substituìdo na posição 4 da trizina com um oxirano na presença de um ácido de lewis
SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
US20090124555A1 (en) * 2005-08-29 2009-05-14 Irma Bernatchez-Lemaire Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents
US20100184802A1 (en) * 2006-03-16 2010-07-22 Kelly Michael G Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
US8093265B2 (en) * 2007-03-09 2012-01-10 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system
NZ587799A (en) 2008-03-25 2012-06-29 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
BRPI1014902A2 (pt) 2009-04-14 2016-04-19 Affectis Pharmaceuticals Ag composto antagonista de p2x7r, sua composição e seus usos
CA2792258A1 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
MX2012013075A (es) 2010-05-14 2012-12-17 Affectis Pharmaceuticals Ag Metodos novedosos para preparacion de antagonistas p2x7r.
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012114268A1 (en) 2011-02-22 2012-08-30 Actelion Pharmaceuticals Ltd Benzamide derivatives as p2x7 receptor antagonists
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
RU2014106611A (ru) 2011-07-22 2015-08-27 Актелион Фармасьютиклз Лтд Производные гетероциклических амидов в качестве антагонистов р2х7 рецептора
EA023752B1 (ru) * 2011-10-03 2016-07-29 Ооо "Эн.Си.Фарм" Фармацевтический состав для инъекций, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты)
NZ628910A (en) 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
EA021231B1 (ru) * 2012-02-29 2015-05-29 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты)
EA020041B1 (ru) * 2012-03-11 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, противоишемической активностью (варианты)
EA021266B1 (ru) * 2012-03-14 2015-05-29 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты)
EA020538B1 (ru) * 2012-03-20 2014-11-28 Ооо "Эн.Си.Фарм" Фармацевтический состав, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, нейрометаболической, противоишемической активностью (варианты)
EA020539B1 (ru) * 2012-03-26 2014-11-28 Ооо "Эн.Си.Фарм" Фармацевтический состав, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, нейрометаболической, противоишемической активностью (варианты)
EA020521B1 (ru) * 2012-03-26 2014-11-28 Ооо "Эн.Си.Фарм" Фармацевтический состав, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, нейрометаболической, противоишемической активностью (варианты)
EA201200393A1 (ru) * 2012-03-30 2013-09-30 Анастасия Геннадьевна ЧЕЛЯЕВА Фармацевтический состав, обладающий противомикробным, бактериостатическим действием (варианты)
EA201200446A1 (ru) * 2012-04-06 2013-10-30 Анастасия Геннадьевна ЧЕЛЯЕВА Твердая лекарственная форма, обладающая отхаркивающим, местным обволакивающим и противовоспалительным действием (варианты)
EA020401B1 (ru) * 2012-07-09 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий натрий, кальций, магний, железо, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020361B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий магний, железо, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020109B1 (ru) * 2012-10-01 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020389B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий натрий, железо, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020403B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий натрий, кальций, магний, железо и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020129B1 (ru) * 2012-10-01 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020404B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий кальций, железо, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020043B1 (ru) * 2012-10-01 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020388B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий натрий, кальций, железо, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020060B1 (ru) * 2012-10-01 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020402B1 (ru) * 2012-10-01 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Фармацевтический состав, содержащий натрий, кальций, цинк и обладающий метаболическим, противокатарактным, ретинопротекторным действием (варианты)
EA020063B1 (ru) * 2012-10-02 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020143B1 (ru) * 2012-10-02 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020061B1 (ru) * 2012-10-02 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020021B1 (ru) * 2012-10-02 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020062B1 (ru) * 2012-10-02 2014-08-29 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая анорексигенным действием (варианты)
EA020162B1 (ru) * 2012-10-04 2014-09-30 Ооо "Эн.Си.Фарм" Твердая лекарственная форма, обладающая желчегонным действием (варианты)
TW201427947A (zh) 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
TWI598325B (zh) 2012-10-12 2017-09-11 Ｈ 朗德貝克公司 苯甲醯胺類
PL2931717T3 (pl) 2012-12-12 2017-05-31 Actelion Pharmaceuticals Ltd. Pochodne indolokarboksyamidu jako antagoniści receptora p2x7
AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
EA024401B1 (ru) * 2012-12-28 2016-09-30 Ооо "Биотехсинтез" Фармацевтический состав, обладающий нейропротекторной, антиамнестической, антиоксидантной, противогипоксической, нейрометаболической, противоишемической активностью (варианты)
ES2616114T3 (es) 2013-01-22 2017-06-09 Actelion Pharmaceuticals Ltd. Derivados de amida heterocíclica como antagonistas del receptor P2X7
EP2956457B1 (en) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
EA201300372A1 (ru) * 2013-04-17 2014-10-30 Ооо "Фармацевтическая Компания "Славянская Аптека" Антиоксидантный фармацевтический состав (варианты)
WO2015099107A1 (ja) * 2013-12-26 2015-07-02 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物
BR112017022654A2 (pt) * 2015-04-24 2018-07-10 Shionogi & Co., Ltd. derivado heterocíclico de 6 membros e composição farmacêutica compreendendo o mesmo
EP3527568A4 (en) 2016-10-17 2020-03-18 Shionogi & Co., Ltd BICYCLIC NITROGEN HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE640616A (enExample) 1962-12-19
US3492397A (en) 1967-04-07 1970-01-27 Warner Lambert Pharmaceutical Sustained release dosage in the pellet form and process thereof
US4060598A (en) 1967-06-28 1977-11-29 Boehringer Mannheim G.M.B.H. Tablets coated with aqueous resin dispersions
US3538214A (en) 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US4173626A (en) 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
AU542544B2 (en) 1980-03-12 1985-02-28 Nippon Kayaku Kabushiki Kaisha Tetrahydrophthalimide derivatives
EP0077938A3 (en) 1981-10-23 1983-08-24 Mitsubishi Kasei Corporation N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
GR80558B (en) 1983-10-08 1985-02-06 Nippon Kayaku Kk Derivative of pyrazole and use thereof as a herbicide
WO1986000072A1 (en) 1984-06-12 1986-01-03 Fmc Corporation Herbicidal 2-aryl-1,2,4-triazine-3,5(2h,4h)-diones and sulfur analogs thereof
US4766233A (en) 1984-06-12 1988-08-23 Fmc Corporation Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs thereof
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
JPH02501388A (ja) 1987-09-23 1990-05-17 チバ　―　ガイギー　アクチエンゲゼルシャフト 複素環式化合物
US5128351A (en) 1990-05-04 1992-07-07 American Cyanamid Company Bis-aryl amide and urea antagonists of platelet activating factor
US5077409A (en) 1990-05-04 1991-12-31 American Cyanamid Company Method of preparing bis-aryl amide and urea antagonists of platelet activating factor
BR9107169A (pt) 1990-12-17 1993-11-16 Shell Int Research Derivados de isoquinolina fungicidas
JP3089621B2 (ja) 1990-12-17 2000-09-18 日産化学工業株式会社 ウラシル誘導体
US5462938A (en) * 1990-12-21 1995-10-31 Annus; Gary D. Arthropodicidal oxadiazinyl, thiadiazinyl and triazinyl carboxanilides
GB9110679D0 (en) 1991-05-17 1991-07-10 Sandoz Ltd Improvements in or relating to organic compounds
GB9119467D0 (en) 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
RU2146674C1 (ru) * 1993-10-15 2000-03-20 Такеда Кемикал Индастриз, Лтд. Производные триазина, способы их получения, антипротозойная композиция, добавка в пищу животных, способ ингибирования протозои у животных
US5691376A (en) 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
DE4405614A1 (de) 1994-02-22 1995-08-24 Bayer Ag Substituierte Triazolinone
US5686061A (en) 1994-04-11 1997-11-11 The Board Of Regents Of The University Of Texas System Particulate contrast media derived from non-ionic water soluble contrast agents for CT enhancement of hepatic tumors
GB9412603D0 (en) 1994-06-23 1994-08-10 Sandoz Ltd Organic compounds
JP3144624B2 (ja) 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
JPH0959236A (ja) * 1995-08-23 1997-03-04 Dai Ichi Seiyaku Co Ltd ベンズアミド化合物
JP3906935B2 (ja) * 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP2001502655A (ja) 1995-12-21 2001-02-27 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害薬であるイソオキサゾリン、イソチアゾリンおよびピラゾリン
PT889877E (pt) 1996-03-29 2002-02-28 Searle & Co Derivados fenileno meta substituidos e sua utilizacao como antagonitas ou inibidores integrina alfa v beta3
CA2263198A1 (en) * 1996-09-06 1998-03-12 Nippon Kayaku Kabushiki Kaisha Novel acetamide derivatives and protease inhibitors
WO1998028269A1 (en) 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
US6187797B1 (en) 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
DE19701287A1 (de) 1997-01-16 1998-07-23 Wernicke & Co Gmbh Verfahren zum Erhöhen der Gebrauchsdauer von Schleifscheiben
US6265409B1 (en) 1997-03-25 2001-07-24 Astrazeneca Ab Pyridine derivatives and pharmaceutical compositions containing them
AU7210398A (en) 1997-03-27 1998-10-22 Novartis Ag Intermediate products and method for the production of pyrimidine derivatives
DE19719621A1 (de) 1997-05-09 1998-11-12 Hoechst Ag Sulfonylaminocarbonsäuren
US5861950A (en) 1997-07-10 1999-01-19 Particle Measuring Systems, Inc. Particle detection system utilizing an inviscid flow-producing nozzle
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
SE9704272D0 (sv) 1997-11-21 1997-11-21 Astra Pharma Prod Novel Compounds
SE9704544D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704546D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
JPH11318492A (ja) 1998-03-09 1999-11-24 Aisin Seiki Co Ltd 蛍光発生性基質を含有する組成物
US6320078B1 (en) 1998-07-24 2001-11-20 Mitsui Chemicals, Inc. Method of producing benzamide derivatives
FR2783519B1 (fr) 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
DE19851184A1 (de) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-Arylsulfonyl-aminosäure-omega-amide
ES2249059T3 (es) 1998-12-16 2006-03-16 Bayer Healthcare Ag Nuevos compuestos de bifenilo y analogos de bifenilo como antagonista de integrina.
WO2000061569A1 (en) 1999-04-09 2000-10-19 Astrazeneca Ab Adamantane derivatives
US6458952B1 (en) * 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
WO2000071512A1 (en) 1999-05-24 2000-11-30 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
SE9901875D0 (sv) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
EP1088821A1 (en) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
MXPA02005102A (es) 1999-10-18 2003-09-25 Alexipharma Inc Retro-anandamidas, ligandos de receptor de canabinoide de alta afinidad y estabilidad.
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904738D0 (sv) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
DE10005284A1 (de) 2000-02-07 2001-08-09 Bayer Ag Verfahren zur Herstellung von 1-Amino-3-aryl-uracilen
GB0006721D0 (en) 2000-03-20 2000-05-10 Mitchell Thomas A Assessment methods and systems
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
WO2003042190A1 (en) * 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
ATE355273T1 (de) 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
RU2006146675A (ru) 2004-06-29 2008-07-10 Пфайзер Продактс Инк. (Us) Способ получения производных 5-[4-(2-гидроксипропил)-3,5-диоксо-4,5-дигидро-3н-[1,2,4] триазин-2-ил] бензамида снятием защиты с промежуточных продуктов, содержащих защищенный гидроксил
BRPI0512651A (pt) 2004-06-29 2008-03-25 Pfizer Prod Inc método para a preparação de derivados de 5-4-(2-hidroxietil)-3,5-dioxo-4,5 dihidro-3h-1,2,4-trizin-2-ila com atividade inibidora de p2x7 por reaçaõ do derivado não substituìdo na posição 4 da trizina com um oxirano na presença de um ácido de lewis

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PE20040802A1 (es) 2004-11-25
UY28153A1 (es) 2004-07-30
TW200413336A (en) 2004-08-01
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US20040180894A1 (en) 2004-09-16
MA27575A1 (fr) 2005-10-03
OA12978A (en) 2006-10-13
AP2005003350A0 (en) 2005-09-30
MY141984A (en) 2010-08-16
ZA200503912B (en) 2006-07-26
US20070281939A1 (en) 2007-12-06
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PA8591801A1 (es) 2004-07-26
CO5580749A2 (es) 2005-11-30

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