MX385381B - Cristal de compuesto que tiene actividad inhibidora de la cinasa de janus (jak). - Google Patents
Cristal de compuesto que tiene actividad inhibidora de la cinasa de janus (jak).Info
- Publication number
- MX385381B MX385381B MX2018010334A MX2018010334A MX385381B MX 385381 B MX385381 B MX 385381B MX 2018010334 A MX2018010334 A MX 2018010334A MX 2018010334 A MX2018010334 A MX 2018010334A MX 385381 B MX385381 B MX 385381B
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- jak
- crystal
- inhibitory activity
- janus kinase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un objeto de la presente invención es proporcionar un compuesto con una excelente actividad inhibidora de JAK1. El compuesto de la invención tiene actividad inhibidora de JAK1, y por lo tanto, efecto inmunosupresor, efecto antiinflamatorio, efecto antiproliferativo, etc., y es útil en el tratamiento de las enfermedades, por ejemplo, artritis reumatoide, enfermedad inflamatoria intestinal, psoriasis, vasculitis, asma bronquial, enfermedad pulmonar obstructiva crónica, sinusitis eosinofílica y pólipo nasal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016039315 | 2016-03-01 | ||
| PCT/JP2017/007594 WO2017150477A1 (ja) | 2016-03-01 | 2017-02-28 | Ｊａｋ阻害作用を有する化合物の結晶 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018010334A MX2018010334A (es) | 2018-11-09 |
| MX385381B true MX385381B (es) | 2025-03-18 |
Family
ID=59743962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018010334A MX385381B (es) | 2016-03-01 | 2017-02-28 | Cristal de compuesto que tiene actividad inhibidora de la cinasa de janus (jak). |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10822350B2 (es) |
| EP (1) | EP3424930B1 (es) |
| JP (1) | JP6791239B2 (es) |
| KR (1) | KR102653231B1 (es) |
| CN (1) | CN108699082B (es) |
| BR (1) | BR112018016523B1 (es) |
| CA (3) | CA3206830A1 (es) |
| CY (1) | CY1123607T1 (es) |
| DK (1) | DK3424930T3 (es) |
| ES (1) | ES2844978T3 (es) |
| HR (1) | HRP20210062T1 (es) |
| HU (1) | HUE051615T2 (es) |
| LT (1) | LT3424930T (es) |
| MX (1) | MX385381B (es) |
| PL (1) | PL3424930T3 (es) |
| PT (1) | PT3424930T (es) |
| RS (1) | RS61238B1 (es) |
| RU (1) | RU2705721C1 (es) |
| SI (1) | SI3424930T1 (es) |
| SM (1) | SMT202000717T1 (es) |
| TW (1) | TWI712604B (es) |
| WO (1) | WO2017150477A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI712604B (zh) * | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
| CN120518557A (zh) * | 2020-09-14 | 2025-08-22 | 欧洲化学安特卫普公司 | N-杂环化合物用作硝化抑制剂 |
| WO2025216268A1 (ja) * | 2024-04-09 | 2025-10-16 | 国立研究開発法人国立循環器病研究センター | 重症肺高血圧症又は膠原病の予防又は治療薬 |
| JP7742516B1 (ja) * | 2025-07-31 | 2025-09-19 | 日本新薬株式会社 | 好酸球性多発血管炎性肉芽腫症の処置剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3600390A1 (de) | 1986-01-09 | 1987-07-16 | Hoechst Ag | Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel |
| US20080207613A1 (en) | 2004-01-12 | 2008-08-28 | Cytopia Research Pty Ltd | Selective Kinase Inhibitors |
| JP2009513571A (ja) * | 2005-09-30 | 2009-04-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | ヤヌスキナーゼ阻害剤として有用なデアザプリン |
| TW201412738A (zh) | 2006-01-17 | 2014-04-01 | Vertex Pharma | 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 |
| TWI444382B (zh) | 2008-03-11 | 2014-07-11 | Incyte Corp | 作為ｊａｋ抑制劑之氮雜環丁烷及環丁烷衍生物 |
| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| WO2010070060A1 (en) * | 2008-12-19 | 2010-06-24 | Nerviano Medical Sciences S.R.L. | Bicyclic pyrazoles as protein kinase inhibitors |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| ES2461967T3 (es) | 2009-12-18 | 2014-05-21 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
| EP2338888A1 (en) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
| JP2011136925A (ja) | 2009-12-28 | 2011-07-14 | Dainippon Sumitomo Pharma Co Ltd | 含窒素二環性化合物 |
| WO2011086053A1 (en) | 2010-01-12 | 2011-07-21 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| WO2012022045A1 (en) | 2010-08-20 | 2012-02-23 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| AU2011302216A1 (en) | 2010-09-14 | 2013-04-04 | Exelixis, Inc. | Phtalazine derivatives as JAK1 inhibitors |
| US8937077B2 (en) | 2010-10-22 | 2015-01-20 | Merck Sharp & Dohme Corp. | Bicyclic diamines as janus kinase inhibitors |
| WO2012085176A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors |
| WO2013025628A1 (en) * | 2011-08-15 | 2013-02-21 | Ligand Pharmaceuticals Incorporated | Janus kinase inhibitor compounds and methods |
| TWI679205B (zh) | 2014-09-02 | 2019-12-11 | 日商日本新藥股份有限公司 | 吡唑并噻唑化合物及醫藥 |
| TWI712604B (zh) * | 2016-03-01 | 2020-12-11 | 日商日本新藥股份有限公司 | 具jak抑制作用之化合物之結晶 |
-
2017
- 2017-02-08 TW TW106104074A patent/TWI712604B/zh active
- 2017-02-28 US US16/077,889 patent/US10822350B2/en active Active
- 2017-02-28 CA CA3206830A patent/CA3206830A1/en active Pending
- 2017-02-28 SI SI201730521T patent/SI3424930T1/sl unknown
- 2017-02-28 HU HUE17759943A patent/HUE051615T2/hu unknown
- 2017-02-28 MX MX2018010334A patent/MX385381B/es unknown
- 2017-02-28 EP EP17759943.8A patent/EP3424930B1/en active Active
- 2017-02-28 KR KR1020187027122A patent/KR102653231B1/ko active Active
- 2017-02-28 CA CA3015464A patent/CA3015464C/en active Active
- 2017-02-28 PL PL17759943T patent/PL3424930T3/pl unknown
- 2017-02-28 WO PCT/JP2017/007594 patent/WO2017150477A1/ja not_active Ceased
- 2017-02-28 CA CA3264321A patent/CA3264321A1/en active Pending
- 2017-02-28 DK DK17759943.8T patent/DK3424930T3/da active
- 2017-02-28 LT LTEP17759943.8T patent/LT3424930T/lt unknown
- 2017-02-28 ES ES17759943T patent/ES2844978T3/es active Active
- 2017-02-28 RU RU2018134041A patent/RU2705721C1/ru active
- 2017-02-28 PT PT177599438T patent/PT3424930T/pt unknown
- 2017-02-28 HR HRP20210062TT patent/HRP20210062T1/hr unknown
- 2017-02-28 BR BR112018016523-9A patent/BR112018016523B1/pt active IP Right Grant
- 2017-02-28 CN CN201780014551.5A patent/CN108699082B/zh active Active
- 2017-02-28 JP JP2018503309A patent/JP6791239B2/ja active Active
- 2017-02-28 SM SM20200717T patent/SMT202000717T1/it unknown
- 2017-02-28 RS RS20201509A patent/RS61238B1/sr unknown
-
2020
- 2020-09-29 US US17/035,947 patent/US11377453B2/en active Active
- 2020-12-02 CY CY20201101142T patent/CY1123607T1/el unknown
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