MX2018005259A - Inhibidores de gelatinasa y uso de los mismos. - Google Patents
Inhibidores de gelatinasa y uso de los mismos.Info
- Publication number
- MX2018005259A MX2018005259A MX2018005259A MX2018005259A MX2018005259A MX 2018005259 A MX2018005259 A MX 2018005259A MX 2018005259 A MX2018005259 A MX 2018005259A MX 2018005259 A MX2018005259 A MX 2018005259A MX 2018005259 A MX2018005259 A MX 2018005259A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- disease
- gelatinase inhibitors
- inflammatory
- gelatinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nuevos inhibidores de gelatinasa, procedimientos para su preparación, composiciones farmacéuticas que los comprenden, y su uso en la terapia y/o profilaxis de afecciones en las que la inhibición de ñas gelatinasas es útil tal como epilepsia, esquizofrenia, enfermedad de Alzheimer, autismo (en particular, asociado al síndrome del cromosoma X frágil), retraso mental, trastornos del estado de ánimo tales como trastornos bipolares, depresión, vasculopatias tales como apoplejía isquémica y aterosclerosis, enfermedades inflamatorias tales como esclerosis múltiple, artritis reumatoide y enfermedad inflamatoria del intestino, toxicomanía, dolor neurópatico, enfermedades pulmonares tales como asma y enfermedad pulmonar obstructiva crónica, cáncer y septicemia. Adicción a las drogas, dolor neuropático, enfermedades pulmonares como asma y enfermedad pulmonar obstructiva crónica, cáncer y sepsis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15382567 | 2015-11-16 | ||
PCT/EP2016/077632 WO2017085034A1 (en) | 2015-11-16 | 2016-11-15 | Gelatinase inhibitors and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018005259A true MX2018005259A (es) | 2018-08-16 |
Family
ID=54754574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005259A MX2018005259A (es) | 2015-11-16 | 2016-11-15 | Inhibidores de gelatinasa y uso de los mismos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US10414797B2 (es) |
EP (1) | EP3377515B1 (es) |
JP (1) | JP6795606B2 (es) |
KR (1) | KR102649684B1 (es) |
CN (1) | CN108290925B (es) |
AU (1) | AU2016356876B2 (es) |
BR (1) | BR112018009641A2 (es) |
CA (1) | CA3002892A1 (es) |
EA (1) | EA036732B1 (es) |
ES (1) | ES2766548T3 (es) |
HK (1) | HK1255029A1 (es) |
IL (1) | IL259286B (es) |
MX (1) | MX2018005259A (es) |
NZ (1) | NZ741898A (es) |
WO (1) | WO2017085034A1 (es) |
ZA (1) | ZA201803212B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107987126B (zh) * | 2017-12-18 | 2018-10-02 | 哈尔滨工业大学 | 4位苯丙酰胺羟基化修饰的内吗啡肽类似物及其合成方法和应用 |
JPWO2022097540A1 (es) * | 2020-11-05 | 2022-05-12 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2573006B2 (ja) | 1987-12-17 | 1997-01-16 | 富士薬品工業株式会社 | 新規なヒドロキサム酸誘導体 |
WO1992022523A2 (en) * | 1991-06-14 | 1992-12-23 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
WO1998015525A1 (fr) * | 1996-10-07 | 1998-04-16 | Sumitomo Pharmaceuticals Co., Ltd. | Acides hydroxamiques |
WO2009097893A1 (en) * | 2008-02-04 | 2009-08-13 | Proyecto De Biomedicina Cima, S.L. | Methods for the treatment of cardiac disease associated to myocardial fibrosis using an inhibitor of pcp |
-
2016
- 2016-11-15 EA EA201891184A patent/EA036732B1/ru unknown
- 2016-11-15 EP EP16795077.3A patent/EP3377515B1/en active Active
- 2016-11-15 BR BR112018009641-5A patent/BR112018009641A2/pt not_active Application Discontinuation
- 2016-11-15 JP JP2018544414A patent/JP6795606B2/ja active Active
- 2016-11-15 AU AU2016356876A patent/AU2016356876B2/en active Active
- 2016-11-15 US US15/776,296 patent/US10414797B2/en active Active
- 2016-11-15 WO PCT/EP2016/077632 patent/WO2017085034A1/en active Application Filing
- 2016-11-15 KR KR1020187016673A patent/KR102649684B1/ko active IP Right Grant
- 2016-11-15 MX MX2018005259A patent/MX2018005259A/es active IP Right Grant
- 2016-11-15 ES ES16795077T patent/ES2766548T3/es active Active
- 2016-11-15 NZ NZ741898A patent/NZ741898A/en unknown
- 2016-11-15 CN CN201680066867.4A patent/CN108290925B/zh active Active
- 2016-11-15 CA CA3002892A patent/CA3002892A1/en active Pending
-
2018
- 2018-05-10 IL IL259286A patent/IL259286B/en unknown
- 2018-05-15 ZA ZA2018/03212A patent/ZA201803212B/en unknown
- 2018-11-06 HK HK18114150.7A patent/HK1255029A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN108290925A (zh) | 2018-07-17 |
WO2017085034A1 (en) | 2017-05-26 |
JP2018535258A (ja) | 2018-11-29 |
IL259286A (en) | 2018-07-31 |
AU2016356876B2 (en) | 2020-10-01 |
CN108290925B (zh) | 2021-12-24 |
AU2016356876A1 (en) | 2018-05-10 |
ES2766548T3 (es) | 2020-06-12 |
KR20180071388A (ko) | 2018-06-27 |
BR112018009641A2 (pt) | 2018-11-06 |
JP6795606B2 (ja) | 2020-12-02 |
EA201891184A1 (ru) | 2018-11-30 |
CA3002892A1 (en) | 2017-05-26 |
US10414797B2 (en) | 2019-09-17 |
IL259286B (en) | 2021-10-31 |
EP3377515B1 (en) | 2019-10-30 |
NZ741898A (en) | 2024-02-23 |
ZA201803212B (en) | 2020-08-26 |
EP3377515A1 (en) | 2018-09-26 |
EA036732B1 (ru) | 2020-12-14 |
KR102649684B1 (ko) | 2024-03-21 |
HK1255029A1 (zh) | 2019-08-02 |
US20180319839A1 (en) | 2018-11-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021015106A (es) | Inhibidores de ferroportina novedosos. | |
PH12017501921A1 (en) | Novel compounds | |
NZ741082A (en) | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses | |
PH12018500828A1 (en) | Jak kinase inhibitor compounds for treatment of respiratory disease | |
MX2018002631A (es) | Inhibidores de molecula pequeña de dyrkia y usos de los mismos. | |
MX2014007254A (es) | Composiciones farmaceuticas que comprenden glitazonas y activadores de nrf2. | |
BR112012026257A2 (pt) | formas sólidas de ácido 3-(6-(1-(2-,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzóico | |
MX2017011778A (es) | Compuestos y composiciones de alfa-cinamida como inhibidores de histona desacetilasa 8 (hdac8). | |
MY183969A (en) | Combination of regorafenib and acetylsalicylic acid for treating cancer | |
IN2014DN07885A (es) | ||
GEP20186885B (en) | Novel compounds | |
IN2014CN03290A (es) | ||
BR112015018071A2 (pt) | estra-1,3,5(10),16-tetraeno-3-carboxamidas | |
NZ741898A (en) | Gelatinase inhibitors and use thereof | |
TN2016000107A1 (en) | Substituted phenylalanine derivatives | |
MX2019006863A (es) | Inhibidores de heparanasa y uso de los mismos. | |
SA520412289B1 (ar) | مركبات مثبط الهدف الميكانيكي للراباميسين | |
PH12017500383B1 (en) | Pyrazolothiazole compound and medicine comprising same | |
EA201790321A1 (ru) | Эластомерные композиции, содержащие усниновую кислоту, и изделия, изготовленные из них или покрытые ими | |
WO2014108336A8 (en) | Pyrazolyl-based carboxamides ii as crac channel inhibitors | |
WO2014108337A8 (en) | Pyrazolyl-based carboxamides i as crac channel inhibitors | |
MX2018010334A (es) | Cristal de compuesto que tiene actividad inhibidora de la cinasa de janus (jak). | |
MX2017003016A (es) | Derivados de piridazinona como inhibidores de las fosfoinositido-3-cinasas. | |
CY1123075T1 (el) | Μεθοδος αγωγης και συνθεσεις που περιλαμβανουν εναν διπλο αναστολεα κινασης ρι3κ δελτα-γαμα και ενα κορτικοστεροειδες | |
MX2020012065A (es) | Compuestos de ciclopentano. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: ACCURE THERAPEUTICS, S.L. |