CO5550430A2 - Derivados terapeuticos de prolina - Google Patents

Derivados terapeuticos de prolina

Info

Publication number
CO5550430A2
CO5550430A2 CO05038508A CO05038508A CO5550430A2 CO 5550430 A2 CO5550430 A2 CO 5550430A2 CO 05038508 A CO05038508 A CO 05038508A CO 05038508 A CO05038508 A CO 05038508A CO 5550430 A2 CO5550430 A2 CO 5550430A2
Authority
CO
Colombia
Prior art keywords
alkyl
amino
pain
acyl
disorders
Prior art date
Application number
CO05038508A
Other languages
English (en)
Inventor
David James Rawson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO5550430A2 publication Critical patent/CO5550430A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- El uso de un compuesto de la fórmula (I) : en la que: o bien X es O, S, NH o CH2 e Y es CH2 o un enlace directo, o bien Y es O, S o NH y X es CH2; yR es un cicloalquilo de 3-12 miembros, heterocicloalquilo de 4-12 miembros, arilo o heteroarilo, pudiendo estar los anillos opcionalmente sustituidos con uno o más sustituyentes seleccionados de manera independiente entre:halógeno, hidroxi, ciano, nitro, amino, hidroxicarbonilo, alquilo(C1-C6), alquenilo(C1-C6), alquinilo(C1-C6), alcoxi(C1-C6), hidroxialquilo(C1-C6), alcoxi(C1-C6)alquilo(C1-C6), perfluoroalquilo(C1-C6), perfluoroalcoxi (C1-C6), alquil(C1-C6)amino, dialquil(C1-C6)amino, aminoalquilo(C1-C6), alquil(C1-C6)aminoalquilo(C1-C6), dialquil(C1-C6) aminoalquilo (C1-C6), acilo (C1-C6), acil (C1-C6) oxi, acil (C1-C6) oxialquilo (C1-C6), acil (C1-C6) amino,alquil(C1-C6)tio, alquil(C1-C6)tiocarbonilo, alquil(C1-C6)tioxo, alcoxi(C1-C6)carbonilo,alquil(C1-C6)sulfonilo, alquil(C1-C6)sulfonilamino, aminosulfonilo, alquil(C1-C6)aminosulfonilo, dialquil(C1-C6)aminosulfonilo,cicloalquilo de 3-8 miembros, heterocicloalquilo de 4-8 miembros, fenilo y heteroarilo monocíclico; o una de sus sales, solvatos o profármacos farmacéuticamente aceptables, en la fabricación de un medicamento para el tratamiento de un trastorno seleccionado entre epilepsia, crisis de desmayos, hipoquinesia, trastornos craneales, trastornos neurodegenerativos, depresión, ansiedad, pánico, dolor, síndrome del intestino irritable, trastornos del sueño, osteoartritis, artritis reumatoide, trastornos neuropatológicos, dolores viscerales, trastornos intestinales funcionales, enfermedades intestinales inflamatorias, dolor asociados con dismenorrea, dolor pélvico, cistitis y pancreatitis.2.- El uso según la reivindicación 1, en el que el trastorno es un dolor.3.- El uso según la reivindicación 1 o la reivindicación 2, siendo R un grupo ciclohexilo, dihidrobenzofuranilo, isoquinolilo o fenilo, opcionalmente sustituido.
CO05038508A 2002-10-31 2005-04-22 Derivados terapeuticos de prolina CO5550430A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0225379.7A GB0225379D0 (en) 2002-10-31 2002-10-31 Therapeutic proline derivatives

Publications (1)

Publication Number Publication Date
CO5550430A2 true CO5550430A2 (es) 2005-08-31

Family

ID=9946940

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05038508A CO5550430A2 (es) 2002-10-31 2005-04-22 Derivados terapeuticos de prolina

Country Status (39)

Country Link
EP (1) EP1558246B1 (es)
JP (2) JP3940416B2 (es)
KR (2) KR20070046213A (es)
CN (1) CN100418525C (es)
AP (1) AP2005003295A0 (es)
AR (1) AR041865A1 (es)
AT (1) ATE468116T1 (es)
AU (1) AU2003269411B2 (es)
BR (1) BR0315839A (es)
CA (1) CA2499698C (es)
CO (1) CO5550430A2 (es)
CR (1) CR7802A (es)
DE (1) DE60332646D1 (es)
DK (1) DK1558246T3 (es)
EA (1) EA009767B1 (es)
EC (1) ECSP055769A (es)
ES (1) ES2343624T3 (es)
GB (1) GB0225379D0 (es)
GE (1) GEP20074127B (es)
GT (1) GT200300234A (es)
HK (1) HK1081441A1 (es)
HR (1) HRP20050351A2 (es)
IL (4) IL167799A (es)
IS (1) IS7754A (es)
MA (1) MA27481A1 (es)
MX (1) MXPA05004662A (es)
NL (1) NL1024677C2 (es)
NO (1) NO330496B1 (es)
OA (1) OA12954A (es)
PA (1) PA8587201A1 (es)
PE (1) PE20040553A1 (es)
PL (1) PL376703A1 (es)
RS (1) RS20050333A (es)
TN (1) TNSN05122A1 (es)
TW (2) TW200633699A (es)
UA (1) UA81437C2 (es)
UY (1) UY28043A1 (es)
WO (1) WO2004039367A1 (es)
ZA (1) ZA200502305B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
US20050043345A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
WO2005097741A1 (en) * 2004-04-05 2005-10-20 Pfizer Limited Process for the recrystallisation of proline derivates
WO2006092692A1 (en) * 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
US7968733B2 (en) 2006-06-06 2011-06-28 Gifu University Pyrrolidine analogue for preventing neurogenic pain and method for production thereof
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
BR112015032180A2 (pt) 2013-06-26 2017-07-25 Zhejiang Jiuzhou Pharm Co Ltd método de preparação de derivados de pirrolidina-2-ácido carboxílico
WO2015003723A1 (en) * 2013-07-12 2015-01-15 Københavns Universitet Substituted 4-proline derivatives as iglur antagonists
CN104418785A (zh) * 2013-09-05 2015-03-18 浙江九洲药业股份有限公司 一种药物中间体的制备方法
CN104829513B (zh) * 2014-02-11 2019-02-19 浙江九洲药业股份有限公司 一种2-羧基-4-甲氧基甲基吡咯烷衍生物的制备方法
CN104844495A (zh) * 2015-06-05 2015-08-19 武汉理工大学 一种(2s,4s)-4-苯硫基-l-脯氨酸盐酸盐的合成方法
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
WO2020120606A1 (en) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions
EP3904339A1 (en) * 2020-04-28 2021-11-03 Esteve Pharmaceuticals, S.A. Alkylaminoproline derivatives as alfa-2-delta-1 blockers

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GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives

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CN100418525C (zh) 2008-09-17
MXPA05004662A (es) 2005-06-08
IL167799A (en) 2011-03-31
ATE468116T1 (de) 2010-06-15
IL201966A (en) 2011-06-30
AP2005003295A0 (en) 2005-06-30
PL376703A1 (pl) 2006-01-09
AU2003269411A1 (en) 2004-05-25
HK1081441A1 (en) 2006-05-19
HRP20050351A2 (en) 2005-10-31
JP2006516115A (ja) 2006-06-22
KR20070046213A (ko) 2007-05-02
GT200300234A (es) 2004-06-23
CA2499698C (en) 2009-01-20
GEP20074127B (en) 2007-06-11
IL201967A (en) 2011-06-30
IL201965A (en) 2011-03-31
CN1711081A (zh) 2005-12-21
ECSP055769A (es) 2005-08-11
MA27481A1 (fr) 2005-08-01
NO20051407D0 (no) 2005-03-17
NO330496B1 (no) 2011-05-02
NO20051407L (no) 2005-07-26
DE60332646D1 (de) 2010-07-01
RS20050333A (en) 2007-06-04
DK1558246T3 (da) 2010-08-09
TW200633699A (en) 2006-10-01
BR0315839A (pt) 2005-09-27
IS7754A (is) 2005-03-17
TNSN05122A1 (fr) 2007-05-14
OA12954A (en) 2006-10-13
TW200416030A (en) 2004-09-01
CR7802A (es) 2007-10-23
ZA200502305B (en) 2006-11-29
UA81437C2 (en) 2008-01-10
KR20050065646A (ko) 2005-06-29
PA8587201A1 (es) 2004-05-26
NL1024677A1 (nl) 2004-05-06
UY28043A1 (es) 2004-05-31
ES2343624T3 (es) 2010-08-05
AU2003269411B2 (en) 2009-06-18
JP3940416B2 (ja) 2007-07-04
EA200500581A1 (ru) 2005-12-29
EA009767B1 (ru) 2008-04-28
GB0225379D0 (en) 2002-12-11
NL1024677C2 (nl) 2005-07-04
CA2499698A1 (en) 2004-05-13
WO2004039367A1 (en) 2004-05-13
EP1558246B1 (en) 2010-05-19
KR100750782B1 (ko) 2007-08-20
PE20040553A1 (es) 2004-08-28
JP2006328078A (ja) 2006-12-07
EP1558246A1 (en) 2005-08-03
AR041865A1 (es) 2005-06-01
JP4555263B2 (ja) 2010-09-29

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