BR9814287A - "4(3)-aminometil-(tio)piran 4(3) substituìdo ou derivados da piperidina (= análogos da gabapentina), sua preparação e seu uso no tratamento de desordens neurológicas" - Google Patents

"4(3)-aminometil-(tio)piran 4(3) substituìdo ou derivados da piperidina (= análogos da gabapentina), sua preparação e seu uso no tratamento de desordens neurológicas"

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Publication number
BR9814287A
BR9814287A BR9814287-9A BR9814287A BR9814287A BR 9814287 A BR9814287 A BR 9814287A BR 9814287 A BR9814287 A BR 9814287A BR 9814287 A BR9814287 A BR 9814287A
Authority
BR
Brazil
Prior art keywords
disorders
benzyl
treatment
straight
uncle
Prior art date
Application number
BR9814287-9A
Other languages
English (en)
Inventor
Justin Stephen Bryans
David Christopher Horwell
Clare Octavia Kneen
David Juergen Wustrow
Original Assignee
Warner Lambert Co
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Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9814287A publication Critical patent/BR9814287A/pt

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    • C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
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Abstract

Patente de Invenção: <B>"4(3)-AMINOMETIL-(TIO)PIRAN 4(3) SUBSTITUìDO OU DERIVADOS DA PIPERIDINA (= ANáLOGOS DA GABAPENTINA), SUA PREPARAçãO E SEU USO NO TRATAMENTO DE DESORDENS NEUROLóGICAS"<D>. São reveladas aminas inéditas de fórmulas (1D) e (1E) ou um sal farmaceuticamente aceitável delas, em que n é um número inteiro de 0 a 2; R é sulfonamida, amida, ácido fosfórico, heterociclo, ácido sulfónico ou ácido hidroxâmico e X é -O-, -S-, -S(O)-, -S(O)~ 2~- ou NR'~ 1~ em que R'~ 1~ é hidrogênio, alquila reta ou ramificada de 1 a 6 átomos de carbono, benzila, -C(O)R'~ 2~ em que R'~ 2~ é alquila reta ou ramificada de 1 a 6 átomos de carbono, benzila ou fenila ou -CO~ 2~R'~ 3~ em que R'~ 3~ é alquila reta ou ramificada de 1 a 6 átomos de carbono ou benzila em que os grupos benzila ou fenila podem ser não-substituídos ou substituídos por de 1 a 3 substituintes selecionados de halogênio, trifluorometila e nitro, e são úteis como agentes no tratamento da epilepsia, ataques de debilidade, hipocinésia, desordens cranianas, desordens neurodegenerativas, depressão, ansiedade, pânico, dor, desordens neuropatológicas, doenças inflamatórias, e desordens gastrintestinais, especialmente IBS.
BR9814287-9A 1997-12-16 1998-11-10 "4(3)-aminometil-(tio)piran 4(3) substituìdo ou derivados da piperidina (= análogos da gabapentina), sua preparação e seu uso no tratamento de desordens neurológicas" BR9814287A (pt)

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US6977397P 1997-12-16 1997-12-16
US10490498P 1998-10-20 1998-10-20
PCT/US1998/023991 WO1999031057A1 (en) 1997-12-16 1998-11-10 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders

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TR200001800T2 (tr) 2001-03-21
CN1279667A (zh) 2001-01-10
HUP0100069A3 (en) 2002-04-29
WO1999031057A1 (en) 1999-06-24
NO20003038L (no) 2000-06-14
EP1045834A1 (en) 2000-10-25
NZ503980A (en) 2002-09-27
PL341231A1 (en) 2001-03-26
CA2304967C (en) 2005-06-14
CA2304967A1 (en) 1999-06-24
IL135315A0 (en) 2001-05-20
US6545022B1 (en) 2003-04-08
NO20003038D0 (no) 2000-06-14
KR20010033153A (ko) 2001-04-25
JP2002508352A (ja) 2002-03-19
AU1455499A (en) 1999-07-05
HUP0100069A2 (hu) 2001-12-28
IS5434A (is) 2000-04-07
AU759392B2 (en) 2003-04-10

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