BR112015032180A2 - método de preparação de derivados de pirrolidina-2-ácido carboxílico - Google Patents

método de preparação de derivados de pirrolidina-2-ácido carboxílico

Info

Publication number
BR112015032180A2
BR112015032180A2 BR112015032180A BR112015032180A BR112015032180A2 BR 112015032180 A2 BR112015032180 A2 BR 112015032180A2 BR 112015032180 A BR112015032180 A BR 112015032180A BR 112015032180 A BR112015032180 A BR 112015032180A BR 112015032180 A2 BR112015032180 A2 BR 112015032180A2
Authority
BR
Brazil
Prior art keywords
carboxylic acid
acid derivatives
preparing pyrrolidine
present
pyrrolidine
Prior art date
Application number
BR112015032180A
Other languages
English (en)
Inventor
Zhang Bin
Che Daqing
Zhu Guoliang
Qian Lingfeng
Ye Wenfa
Li Yuanqiang
Original Assignee
Zhejiang Jiuzhou Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201410255311.2A external-priority patent/CN104276991B/zh
Application filed by Zhejiang Jiuzhou Pharm Co Ltd filed Critical Zhejiang Jiuzhou Pharm Co Ltd
Publication of BR112015032180A2 publication Critical patent/BR112015032180A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

a presente invenção refere-se ao campo da síntese médica, em particular a um método de preparo de derivados de pirrolidina-2-ácido carboxílico. a presente invenção adota a seguinte solução técnica: fornecimento de um composto possuindo a estrutura de fórmula (e), em que r é r1 ou r2, r1 é um grupo c1~c6 alquila, benzila, p-metoxibenzila ou p-nitrobenzila, e r2 é hidrogênio. r3 é um grupo protetor do grupo carboxila, e p1 é um grupo protetor em nitrogênio.
BR112015032180A 2013-06-26 2014-06-23 método de preparação de derivados de pirrolidina-2-ácido carboxílico BR112015032180A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201310261857 2013-06-26
CN201310580894 2013-11-19
CN201410255311.2A CN104276991B (zh) 2013-06-26 2014-06-10 一种2‑羧酸吡咯烷衍生物的制备方法
PCT/CN2014/080520 WO2014206257A1 (zh) 2013-06-26 2014-06-23 一种2-羧酸吡咯烷衍生物的制备方法

Publications (1)

Publication Number Publication Date
BR112015032180A2 true BR112015032180A2 (pt) 2017-07-25

Family

ID=54850556

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015032180A BR112015032180A2 (pt) 2013-06-26 2014-06-23 método de preparação de derivados de pirrolidina-2-ácido carboxílico

Country Status (12)

Country Link
US (1) US9902693B2 (pt)
EP (1) EP3015456A4 (pt)
JP (1) JP2016523266A (pt)
KR (1) KR20160024875A (pt)
AU (1) AU2014301821A1 (pt)
BR (1) BR112015032180A2 (pt)
CA (1) CA2915517A1 (pt)
EA (1) EA201592167A1 (pt)
IL (1) IL243038A0 (pt)
MX (1) MX2015017864A (pt)
SG (1) SG11201510256WA (pt)
WO (1) WO2014206257A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104695023B (zh) * 2015-02-14 2017-02-01 河北科技大学 一水合四氢吡咯‑2‑羧酸单晶及其制备方法
CN105399654B (zh) * 2015-12-21 2018-04-06 北京工业大学 2,3‑二氢吡咯类化合物、制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0225379D0 (en) 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
WO2005073186A1 (ja) * 2004-01-29 2005-08-11 Ono Pharmaceutical Co., Ltd. ピロリジン誘導体
WO2006073167A1 (ja) 2005-01-07 2006-07-13 Ono Pharmaceutical Co., Ltd. ピロリジン誘導体
EP2268641B1 (en) 2008-03-26 2014-09-03 Advinus Therapeutics Pvt. Ltd. Heterocyclic compounds as adenosine receptor antagonist
EP3699176A3 (en) 2010-11-17 2020-11-18 Gilead Pharmasset LLC Antiviral compounds

Also Published As

Publication number Publication date
SG11201510256WA (en) 2016-01-28
WO2014206257A1 (zh) 2014-12-31
EP3015456A1 (en) 2016-05-04
CA2915517A1 (en) 2014-12-31
AU2014301821A1 (en) 2015-12-24
US20160145208A1 (en) 2016-05-26
US9902693B2 (en) 2018-02-27
EP3015456A4 (en) 2016-11-16
JP2016523266A (ja) 2016-08-08
EA201592167A1 (ru) 2016-05-31
KR20160024875A (ko) 2016-03-07
IL243038A0 (en) 2016-02-01
MX2015017864A (es) 2016-04-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]