AR041865A1 - Derivados terapeuticos de prolina y su uso en el tratamiento de epilepsia y dolor - Google Patents
Derivados terapeuticos de prolina y su uso en el tratamiento de epilepsia y dolorInfo
- Publication number
- AR041865A1 AR041865A1 ARP030103960A ARP030103960A AR041865A1 AR 041865 A1 AR041865 A1 AR 041865A1 AR P030103960 A ARP030103960 A AR P030103960A AR P030103960 A ARP030103960 A AR P030103960A AR 041865 A1 AR041865 A1 AR 041865A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- epilepsy
- pain
- treatment
- prolina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de la fórmula (1) o una de sus sales, solvatos o profármacos farmacéuticamente aceptables, son derivados de prolina, útiles en el tratamiento de epilepsia, crisis de desmayos, hipoquinesia, trastornos craneales, trastornos neurodegenerativos, depresión, ansiedad, pánico, dolor, fibromialgia, artritis, trastornos neuropatológicos, trastornos del sueno, trastornos asociados con dolores gastrointestinales. Se incluyen procedimientos para la preparación de los productos finales y de intermediarios útiles en el procedimiento. también se incluyen composiciones farmacéuticas que contienen uno o más de los compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0225379.7A GB0225379D0 (en) | 2002-10-31 | 2002-10-31 | Therapeutic proline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR041865A1 true AR041865A1 (es) | 2005-06-01 |
Family
ID=9946940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030103960A AR041865A1 (es) | 2002-10-31 | 2003-10-29 | Derivados terapeuticos de prolina y su uso en el tratamiento de epilepsia y dolor |
Country Status (39)
Country | Link |
---|---|
EP (1) | EP1558246B1 (es) |
JP (2) | JP3940416B2 (es) |
KR (2) | KR100750782B1 (es) |
CN (1) | CN100418525C (es) |
AP (1) | AP2005003295A0 (es) |
AR (1) | AR041865A1 (es) |
AT (1) | ATE468116T1 (es) |
AU (1) | AU2003269411B2 (es) |
BR (1) | BR0315839A (es) |
CA (1) | CA2499698C (es) |
CO (1) | CO5550430A2 (es) |
CR (1) | CR7802A (es) |
DE (1) | DE60332646D1 (es) |
DK (1) | DK1558246T3 (es) |
EA (1) | EA009767B1 (es) |
EC (1) | ECSP055769A (es) |
ES (1) | ES2343624T3 (es) |
GB (1) | GB0225379D0 (es) |
GE (1) | GEP20074127B (es) |
GT (1) | GT200300234A (es) |
HK (1) | HK1081441A1 (es) |
HR (1) | HRP20050351A2 (es) |
IL (4) | IL167799A (es) |
IS (1) | IS7754A (es) |
MA (1) | MA27481A1 (es) |
MX (1) | MXPA05004662A (es) |
NL (1) | NL1024677C2 (es) |
NO (1) | NO330496B1 (es) |
OA (1) | OA12954A (es) |
PA (1) | PA8587201A1 (es) |
PE (1) | PE20040553A1 (es) |
PL (1) | PL376703A1 (es) |
RS (1) | RS20050333A (es) |
TN (1) | TNSN05122A1 (es) |
TW (2) | TW200633699A (es) |
UA (1) | UA81437C2 (es) |
UY (1) | UY28043A1 (es) |
WO (1) | WO2004039367A1 (es) |
ZA (1) | ZA200502305B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
WO2005097741A1 (en) * | 2004-04-05 | 2005-10-20 | Pfizer Limited | Process for the recrystallisation of proline derivates |
WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
JP5138589B2 (ja) * | 2006-06-06 | 2013-02-06 | 浜松ホトニクス株式会社 | 神経因性疼痛を抑制するピロリジン類縁体及びその製造方法 |
AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
MX2015017864A (es) | 2013-06-26 | 2016-04-15 | Zhejiang Jiuzhou Pharm Co Ltd | Metodo de preparacion de derivados de acido pirrolidina-2-carboxil ico. |
WO2015003723A1 (en) * | 2013-07-12 | 2015-01-15 | Københavns Universitet | Substituted 4-proline derivatives as iglur antagonists |
CN104418785A (zh) * | 2013-09-05 | 2015-03-18 | 浙江九洲药业股份有限公司 | 一种药物中间体的制备方法 |
CN104829513B (zh) * | 2014-02-11 | 2019-02-19 | 浙江九洲药业股份有限公司 | 一种2-羧基-4-甲氧基甲基吡咯烷衍生物的制备方法 |
CN104844495A (zh) * | 2015-06-05 | 2015-08-19 | 武汉理工大学 | 一种(2s,4s)-4-苯硫基-l-脯氨酸盐酸盐的合成方法 |
WO2020120606A1 (en) * | 2018-12-12 | 2020-06-18 | Esteve Pharmaceuticals, S.A. | New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions |
TW202026281A (zh) * | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
EP3904339A1 (en) * | 2020-04-28 | 2021-11-03 | Esteve Pharmaceuticals, S.A. | Alkylaminoproline derivatives as alfa-2-delta-1 blockers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316906A (en) * | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
ZA817601B (en) * | 1980-11-24 | 1982-10-27 | Squibb & Sons Inc | Carboxyalkyl amino acid derivatives of various substituted prolines |
JPH07504155A (ja) * | 1991-04-19 | 1995-05-11 | シオス・ノヴァ・インコーポレイテット | ブラジキニンアンタゴニストペプチド |
US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
US6156726A (en) * | 1996-08-02 | 2000-12-05 | Elan Pharmaceuticals, Inc. | Voltage-gated calcium channel antagonist and method |
JP3196106B2 (ja) * | 1997-03-27 | 2001-08-06 | 参天製薬株式会社 | ロイコトリエンa4ヒドロラーゼ阻害剤 |
JP2002516312A (ja) * | 1998-05-26 | 2002-06-04 | ワーナー−ランバート・カンパニー | カルシウムチャンネルのα2δサブユニットに対する親和性を有する立体配座的に制約されたアミノ酸化合物 |
CO5300399A1 (es) * | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
-
2002
- 2002-10-31 GB GBGB0225379.7A patent/GB0225379D0/en not_active Ceased
-
2003
- 2003-10-22 OA OA1200500132A patent/OA12954A/en unknown
- 2003-10-22 WO PCT/IB2003/004697 patent/WO2004039367A1/en active Application Filing
- 2003-10-22 CN CNB2003801024978A patent/CN100418525C/zh not_active Expired - Fee Related
- 2003-10-22 KR KR1020057007561A patent/KR100750782B1/ko not_active IP Right Cessation
- 2003-10-22 EP EP03751192A patent/EP1558246B1/en not_active Expired - Lifetime
- 2003-10-22 AU AU2003269411A patent/AU2003269411B2/en not_active Ceased
- 2003-10-22 DE DE60332646T patent/DE60332646D1/de not_active Expired - Lifetime
- 2003-10-22 PL PL376703A patent/PL376703A1/pl not_active Application Discontinuation
- 2003-10-22 MX MXPA05004662A patent/MXPA05004662A/es active IP Right Grant
- 2003-10-22 CA CA002499698A patent/CA2499698C/en not_active Expired - Fee Related
- 2003-10-22 GE GEAP20038772A patent/GEP20074127B/en unknown
- 2003-10-22 KR KR1020077008828A patent/KR20070046213A/ko not_active Application Discontinuation
- 2003-10-22 BR BR0315839-0A patent/BR0315839A/pt not_active IP Right Cessation
- 2003-10-22 UA UAA200504092A patent/UA81437C2/uk unknown
- 2003-10-22 AT AT03751192T patent/ATE468116T1/de not_active IP Right Cessation
- 2003-10-22 JP JP2004547896A patent/JP3940416B2/ja not_active Expired - Fee Related
- 2003-10-22 DK DK03751192.0T patent/DK1558246T3/da active
- 2003-10-22 ES ES03751192T patent/ES2343624T3/es not_active Expired - Lifetime
- 2003-10-22 RS YUP-2005/0333A patent/RS20050333A/sr unknown
- 2003-10-22 EA EA200500581A patent/EA009767B1/ru not_active IP Right Cessation
- 2003-10-22 AP AP2005003295A patent/AP2005003295A0/xx unknown
- 2003-10-27 UY UY28043A patent/UY28043A1/es not_active Application Discontinuation
- 2003-10-28 GT GT200300234A patent/GT200300234A/es unknown
- 2003-10-29 PE PE2003001093A patent/PE20040553A1/es not_active Application Discontinuation
- 2003-10-29 AR ARP030103960A patent/AR041865A1/es not_active Application Discontinuation
- 2003-10-30 TW TW095122538A patent/TW200633699A/zh unknown
- 2003-10-30 TW TW092130304A patent/TW200416030A/zh unknown
- 2003-10-30 PA PA20038587201A patent/PA8587201A1/es unknown
- 2003-10-31 NL NL1024677A patent/NL1024677C2/nl not_active IP Right Cessation
-
2005
- 2005-03-17 NO NO20051407A patent/NO330496B1/no not_active IP Right Cessation
- 2005-03-17 IS IS7754A patent/IS7754A/is unknown
- 2005-03-18 ZA ZA200502305A patent/ZA200502305B/en unknown
- 2005-03-31 IL IL167799A patent/IL167799A/en not_active IP Right Cessation
- 2005-04-19 HR HR20050351A patent/HRP20050351A2/hr not_active Application Discontinuation
- 2005-04-21 CR CR7802A patent/CR7802A/es not_active Application Discontinuation
- 2005-04-22 CO CO05038508A patent/CO5550430A2/es not_active Application Discontinuation
- 2005-04-29 EC EC2005005769A patent/ECSP055769A/es unknown
- 2005-04-29 TN TNP2005000122A patent/TNSN05122A1/fr unknown
- 2005-04-29 MA MA28242A patent/MA27481A1/fr unknown
-
2006
- 2006-02-08 HK HK06101658A patent/HK1081441A1/xx not_active IP Right Cessation
- 2006-07-25 JP JP2006201384A patent/JP4555263B2/ja not_active Expired - Fee Related
-
2009
- 2009-11-05 IL IL201965A patent/IL201965A/en not_active IP Right Cessation
- 2009-11-05 IL IL201967A patent/IL201967A/en not_active IP Right Cessation
- 2009-11-05 IL IL201966A patent/IL201966A/en not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR7802A (es) | Derivados de prolina que presentan afinidad por la subunidad alfa-2-delta del canal de calcio | |
UY27740A1 (es) | Nuevos compuestos | |
CU23112A3 (es) | AMINOáCIDOS BICICLICOS COMO AGENTES FARMACéUTICOS | |
ECSP066299A (es) | Polipéptidos cristalinos del receptor 2 del factor de necrosis de tumor | |
UY26782A1 (es) | Derivados del benzotiazol | |
ECSP088405A (es) | Nuevos derivados de pirimidina y su uso en terapia, así como el uso de derivados de pirimidina en la fabricación de un medicamento para la prevención y/o tratamiento de la enfermedad de alzheimer | |
CO4810373A1 (es) | Compuestos azapoliciclicos condensados con arilo | |
ECSP088499A (es) | Nuevos compuestos de 2-amino-imidazol-4-ona y su uso en la fabricación de un medicamento para uso en el tratamiento de alteración cognitiva, enfermedad de alzheimer, neurodegeneración y demencia | |
ECSP034732A (es) | Derivado de fenetanolamina para el tratamiento de enfermedades respiratorias | |
AR062536A1 (es) | Acilanilidas sustituidas y composicion farmaceutica | |
CR9954A (es) | Derivados de pirazina | |
AR005458A1 (es) | 2-oxo-y 2-tio-1,2-dihidroquinolinil-oxazolidinonas, procedimiento para su produccion, el uso de las mismas para la produccion de un medicamento ymedicamentos que los contienen | |
AR002289A1 (es) | Derivados de acetamida, procedimiento para prepararlos, las composiciones farmaceuticas que los contienen y las aplicaciones de dichos compuestos comoansioliticos y en el tratamiento de enfermedades inmuno-inflamatorias. | |
PA8587101A1 (es) | Nuevos derivados de dihidropirimido [4,5-d] pirimidinona sustituida por amiino, fabricacion y uso de los mismos como agentes farmaceuticos | |
UY27427A1 (es) | Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos | |
AR024060A1 (es) | Nuevos compuestos farmaceuticamente activos | |
UY29818A1 (es) | Nuevos compuestos de azetidina, composiciones farmaceuticas que los contienen, procesos de preparacion y sus usos terapeuticos | |
CY1106645T1 (el) | Παραγωγα 1,2,4 τριαμινοβενζολης χρησιμα για τη θεραπευτικη αντιμετωπιση διαταραχων του κεντρικου νευρικου συστηματος | |
ECSP034518A (es) | Nuevos retinoides para el tratamiento de enfisema | |
DK1751097T3 (da) | Substituerede N-aryl-benzamider og relaterede sammensætninger til behandling af amyloid-sygdomme og synukleinopatier | |
UY27700A1 (es) | Compuestos oxo - azabiclícos. | |
UY29823A1 (es) | Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones | |
AR066455A2 (es) | Uso de compuestos n-metil-n-[(1r)-1-fenil-2-(3r)-3-hidroxipirrolidin -1-il-=-etil]-2,2-difenilacetamida para producir un medicamento para el tratamiento de emfermedades intestinales no inflamatorias | |
UY28377A1 (es) | Agentes terapeuticos | |
ES2253378T3 (es) | Extractos de espermatofitos con actividad antineoplasica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |