CO5190688A1 - Formas farmaceuticas de administracion oral al menos parcialmente retardadas cuya sustancia activa tramadol se encuentra al menos parcialmente en forma de compuesto formado in situ con una hidrosolubilidad 100 mg/ml, y procedimientos para su preparac - Google Patents

Formas farmaceuticas de administracion oral al menos parcialmente retardadas cuya sustancia activa tramadol se encuentra al menos parcialmente en forma de compuesto formado in situ con una hidrosolubilidad 100 mg/ml, y procedimientos para su preparac

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Publication number
CO5190688A1
CO5190688A1 CO00064191A CO00064191A CO5190688A1 CO 5190688 A1 CO5190688 A1 CO 5190688A1 CO 00064191 A CO00064191 A CO 00064191A CO 00064191 A CO00064191 A CO 00064191A CO 5190688 A1 CO5190688 A1 CO 5190688A1
Authority
CO
Colombia
Prior art keywords
partially
active substance
oral administration
situ
delayed
Prior art date
Application number
CO00064191A
Other languages
English (en)
Inventor
Iris Ziegler
Johannes Bartholomaus
Original Assignee
Gruenenthal Chemie
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Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CO5190688A1 publication Critical patent/CO5190688A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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Abstract

Formas farmacéuticas de administración oral de tramadol, al menos parcialmente retardada, caracterizadas porque la proporción retardada de la sustancia activa farmacéutica está constituida por un compuesto formado in situ de tramadol y otro excipiente ácido y/o sustancia activa farmacéutica ácida con una solubilidad en agua ANDlt; 100 mg/ml. Procedimiento de preparación de formas de administración oral al menos parcialmente retardadas según una de las reivindicaciones 1 a 19, caracterizado porque se mezclan tramadol y un excipiente ácido y/o una sustancia activa farmacéutica ácida o sus correspondientes sales hidrosolubles y eventualmente otros excipientes, se humedecen varias veces y se formulan con aporte de energía.
CO00064191A 1999-08-31 2000-08-28 Formas farmaceuticas de administracion oral al menos parcialmente retardadas cuya sustancia activa tramadol se encuentra al menos parcialmente en forma de compuesto formado in situ con una hidrosolubilidad 100 mg/ml, y procedimientos para su preparac CO5190688A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19940944A DE19940944B4 (de) 1999-08-31 1999-08-31 Retardierte, orale, pharmazeutische Darreichungsformen

Publications (1)

Publication Number Publication Date
CO5190688A1 true CO5190688A1 (es) 2002-08-29

Family

ID=7919964

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00064191A CO5190688A1 (es) 1999-08-31 2000-08-28 Formas farmaceuticas de administracion oral al menos parcialmente retardadas cuya sustancia activa tramadol se encuentra al menos parcialmente en forma de compuesto formado in situ con una hidrosolubilidad 100 mg/ml, y procedimientos para su preparac

Country Status (29)

Country Link
US (2) US7906141B2 (es)
EP (2) EP1627633A1 (es)
JP (1) JP2003508428A (es)
KR (1) KR100735509B1 (es)
CN (1) CN1201732C (es)
AR (2) AR025428A1 (es)
AT (1) ATE320799T1 (es)
AU (1) AU781707B2 (es)
BR (1) BR0013823A (es)
CA (1) CA2382098C (es)
CO (1) CO5190688A1 (es)
CZ (1) CZ298948B6 (es)
DE (2) DE19940944B4 (es)
DK (1) DK1207867T3 (es)
ES (1) ES2260042T3 (es)
HK (1) HK1047231B (es)
HU (1) HUP0302086A2 (es)
IL (2) IL148407A0 (es)
MX (1) MXPA02002197A (es)
MY (1) MY129234A (es)
NO (1) NO20020976L (es)
NZ (1) NZ517554A (es)
PE (1) PE20010532A1 (es)
PL (1) PL354239A1 (es)
PT (1) PT1207867E (es)
RU (1) RU2240786C2 (es)
SK (1) SK285943B6 (es)
WO (1) WO2001015681A1 (es)
ZA (3) ZA200202480B (es)

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