CR7074A - Derivados de mercaptoacetylamida y proceso para su preparacion y uso - Google Patents

Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Info

Publication number
CR7074A
CR7074A CR7074A CR7074A CR7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A
Authority
CR
Costa Rica
Prior art keywords
compounds
inhibitory activity
heart failure
relates
present
Prior art date
Application number
CR7074A
Other languages
English (en)
Inventor
A Flynn Gary
Mehdi Shujaath
Roger Koehl Jack
Ann Anderson Barbara
Gerken Manfred
Jablonka Bernd
Kleeman Heinz-Werner
Linz Wolfgang
Seiz Werner
Seuring Bernhard
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CR7074A publication Critical patent/CR7074A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a nuevos compuestos que poseen tanto actividad inhibidora de la enzima convertidota de angiotensina, como actividad inhibidora de la endopeptidasa neutra, y a metodos para preparar dichos compuestos. La presente invencion se refiere asi mismo a composiciones farmaceuticas que contienen dichos compuestos inhibidores dobles o sus sales farmaceuticamente aceptables y a su uso en la fabricacion de medicamentos usados en la insuficiencia cardiaca, para reducir la mortalidad en pacientes con insuficiencia cardiaca (ICC) o con disfuncion ventricular izquierda, tras un infarto del miocardio, insuficiencia renal, hipertension esencial y la cirrosis.
CR7074A 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso CR7074A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (1)

Publication Number Publication Date
CR7074A true CR7074A (es) 2007-12-04

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7074A CR7074A (es) 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Country Status (17)

Country Link
US (1) US6602866B2 (es)
KR (1) KR100910929B1 (es)
AR (1) AR034307A1 (es)
CR (1) CR7074A (es)
DK (1) DK1381605T3 (es)
EC (1) ECSP034782A (es)
GB (1) GB0119305D0 (es)
GT (1) GT200200069A (es)
IL (1) IL158289A (es)
MY (1) MY128226A (es)
PE (1) PE20021079A1 (es)
RS (1) RS50919B (es)
TN (1) TNSN03083A1 (es)
TW (1) TWI319764B (es)
UA (1) UA75647C2 (es)
UY (1) UY27255A1 (es)
ZA (1) ZA200307096B (es)

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TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
JP6088047B2 (ja) 2012-05-31 2017-03-01 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 一酸化窒素ドナーであるネプリライシン阻害剤
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
RS55967B1 (sr) 2012-06-08 2017-09-29 Theravance Biopharma R&D Ip Llc Inhibitori neprilizina
DK2882716T3 (en) 2012-08-08 2017-03-06 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
PT2964616T (pt) 2013-03-05 2017-08-08 Theravance Biopharma R&D Ip Llc Inibidores da neprilisina
AU2015210983B2 (en) 2014-01-30 2018-10-04 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
EP3099668B1 (en) 2014-01-30 2022-05-04 Theravance Biopharma R&D IP, LLC 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
WO2016130650A1 (en) 2015-02-11 2016-08-18 Theravance Biopharma R&D Ip, Llc (2s, 4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
RU2715241C2 (ru) 2015-02-19 2020-02-26 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用

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Also Published As

Publication number Publication date
KR100910929B1 (ko) 2009-08-06
GT200200069A (es) 2002-12-17
AR034307A1 (es) 2004-02-18
IL158289A (en) 2010-11-30
ECSP034782A (es) 2003-12-01
UY27255A1 (es) 2002-07-31
ZA200307096B (en) 2004-09-06
GB0119305D0 (en) 2001-10-03
MY128226A (en) 2007-01-31
UA75647C2 (en) 2006-05-15
TWI319764B (en) 2010-01-21
KR20040008153A (ko) 2004-01-28
TNSN03083A1 (en) 2005-12-23
DK1381605T3 (da) 2005-05-09
YU78703A (sh) 2006-05-25
RS50919B (sr) 2010-08-31
PE20021079A1 (es) 2003-02-19
US6602866B2 (en) 2003-08-05
US20020193589A1 (en) 2002-12-19

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Legal Events

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