YU78703A - Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba - Google Patents

Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba

Info

Publication number
YU78703A
YU78703A YU78703A YUP78703A YU78703A YU 78703 A YU78703 A YU 78703A YU 78703 A YU78703 A YU 78703A YU P78703 A YUP78703 A YU P78703A YU 78703 A YU78703 A YU 78703A
Authority
YU
Yugoslavia
Prior art keywords
compounds
preparation
disclosed
mercaptoacetylamide derivatives
mercaptoacetylamide
Prior art date
Application number
YU78703A
Other languages
English (en)
Inventor
Gary A. Flynn
Jack Roger Koehl
Manfred Gerken
Heinz-Werner Kleemann
Werner Seiz
Shujaath Mehdi
Barbara Ann Anderson
Bernd Jablonka
Wolfgang Linz
Bernhard Seuring
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU78703A publication Critical patent/YU78703A/sh
Publication of RS50919B publication Critical patent/RS50919B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ovaj pronalazak otkriva i daje u patentnim zahtevima seriju derivata merkaptoacetilamida formule (I).. Ovde su takodje otkrivene i date u patentnim zahtevima farmaceutske kompozicije koje obuhvataju ova jedinjenja i postupci za pripremanje pomenutih jedinjenja. Upotreba pomenutih jedinjenja za inhibiciiju enzima koji konvertuje angiotenzin i neutralnih endopeptidaza i za lečenje hipertenzije ikongestivnog poremećaja srca su takodje ovde otkriveni i dati u patentnim zahtevima.[This invention discloses and claims a series of mercaptoacetylamide derivatives of formula (I). Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds for inhibition of the enzymes angiotensin converting enzyme and neutral endopeptidase, and for the treatment of hypertension and congestive heart failure are also disclosed and claimed.
YUP-787/03A 2001-04-12 2002-04-03 Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba RS50919B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (2)

Publication Number Publication Date
YU78703A true YU78703A (sh) 2006-05-25
RS50919B RS50919B (sr) 2010-08-31

Family

ID=23085405

Country Status (17)

Country Link
US (1) US6602866B2 (sh)
KR (1) KR100910929B1 (sh)
AR (1) AR034307A1 (sh)
CR (1) CR7074A (sh)
DK (1) DK1381605T3 (sh)
EC (1) ECSP034782A (sh)
GB (1) GB0119305D0 (sh)
GT (1) GT200200069A (sh)
IL (1) IL158289A (sh)
MY (1) MY128226A (sh)
PE (1) PE20021079A1 (sh)
RS (1) RS50919B (sh)
TN (1) TNSN03083A1 (sh)
TW (1) TWI319764B (sh)
UA (1) UA75647C2 (sh)
UY (1) UY27255A1 (sh)
ZA (1) ZA200307096B (sh)

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ES2609810T3 (es) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina donadores de óxido nítrico
WO2013184934A1 (en) 2012-06-08 2013-12-12 Theravance, Inc. Neprilysin inhibitors
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
PT2882716T (pt) 2012-08-08 2017-03-13 Theravance Biopharma R&D Ip Llc Inibidores da neprilisina
CA2902456A1 (en) 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CA2934936A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
JP2017504625A (ja) 2014-01-30 2017-02-09 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての５−ビフェニル−４−ヘテロアリールカルボニルアミノ−ペンタン酸誘導体
ES2923002T3 (es) 2015-02-11 2022-09-22 Theravance Biopharma R&D Ip Llc Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina
SI3259255T1 (sl) 2015-02-19 2021-04-30 Theravance Biopharma R&D Ip, Llc (2R,4R)-5-(5'-kloro-2'-fluorobifenil-4-IL)-2-hidroksi-4-((5-metiloksa- zol-2-karbonil)amino)pentanojska kislina
US10100021B2 (en) 2016-03-08 2018-10-16 Theravance Biopharma R&D Ip, Llc Crystalline(2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof

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Also Published As

Publication number Publication date
US20020193589A1 (en) 2002-12-19
GB0119305D0 (en) 2001-10-03
MY128226A (en) 2007-01-31
PE20021079A1 (es) 2003-02-19
UA75647C2 (en) 2006-05-15
IL158289A (en) 2010-11-30
CR7074A (es) 2007-12-04
ZA200307096B (en) 2004-09-06
KR20040008153A (ko) 2004-01-28
ECSP034782A (es) 2003-12-01
KR100910929B1 (ko) 2009-08-06
DK1381605T3 (da) 2005-05-09
US6602866B2 (en) 2003-08-05
AR034307A1 (es) 2004-02-18
GT200200069A (es) 2002-12-17
TWI319764B (en) 2010-01-21
TNSN03083A1 (en) 2005-12-23
RS50919B (sr) 2010-08-31
UY27255A1 (es) 2002-07-31

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