RS50919B - Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba - Google Patents
Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotrebaInfo
- Publication number
- RS50919B RS50919B YUP-787/03A YUP78703A RS50919B RS 50919 B RS50919 B RS 50919B YU P78703 A YUP78703 A YU P78703A RS 50919 B RS50919 B RS 50919B
- Authority
- RS
- Serbia
- Prior art keywords
- aryl
- alkyl
- hydrogen
- preparation
- methylenedioxy
- Prior art date
Links
- GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical class NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- -1 aryl- (C1-C4-alkyl) Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Jedinjenje formule I:gde:R1 je vodonik, -CH2OC(O)C(CH3)3, ili acil grupa;R2 je vodonik, -CH2O-C(O)C(CH3)3, C1-C4-alkil, aril, aril-( C1-C4-alkil), ili difenilmetil; X je -(CH2)n gde je n broj 0 ili 1, -S-, -O-,pri čemu R3 je vodonik, C1-C4-alkil, aril, ili aril-( C1-C4-alkil), i R4 je -CF3, C1-C10-alkil, aril, ili aril-( C1-C4-alkil);B1 i B2 su svaki nezavisno vodonik, hidroksi, ili -OR5, pri čemu R5 je C1-C4-alkil, aril, ili aril-(C1-C4-alkil), ili, gde su B1 i B2 vezani za susedne atome ugljenika, B1 i B2 mogu zajedno sa susednim atomima ugljenika da obrazuju benzenov prsten ili metilendioksi; pri čemu aril je fenil ili naftil grupa neuspstituisana ili supstitusana sa jedan do tri supstituenta odabrana iz grupe koju čine metilendioksi, hidroksi, C1-C4-alkoksi, fluor i hlor; ili njegove faramceutski prihvatljive soli ili njihovi stereoizomeri.Prijava sadrži još 19 patentnih zahteva
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28330501P | 2001-04-12 | 2001-04-12 | |
| GBGB0119305.1A GB0119305D0 (en) | 2001-04-12 | 2001-08-08 | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU78703A YU78703A (sh) | 2006-05-25 |
| RS50919B true RS50919B (sr) | 2010-08-31 |
Family
ID=23085405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-787/03A RS50919B (sr) | 2001-04-12 | 2002-04-03 | Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6602866B2 (sr) |
| KR (1) | KR100910929B1 (sr) |
| AR (1) | AR034307A1 (sr) |
| CR (1) | CR7074A (sr) |
| DK (1) | DK1381605T3 (sr) |
| EC (1) | ECSP034782A (sr) |
| GB (1) | GB0119305D0 (sr) |
| GT (1) | GT200200069A (sr) |
| IL (1) | IL158289A (sr) |
| MY (1) | MY128226A (sr) |
| PE (1) | PE20021079A1 (sr) |
| RS (1) | RS50919B (sr) |
| TN (1) | TNSN03083A1 (sr) |
| TW (1) | TWI319764B (sr) |
| UA (1) | UA75647C2 (sr) |
| UY (1) | UY27255A1 (sr) |
| ZA (1) | ZA200307096B (sr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1481960A4 (en) * | 2002-02-04 | 2005-04-06 | Kaneka Corp | PROCESS FOR OBTAINING OPTICALLY ACTIVE 2-HALOGENO-CARBOXYLIC ACIDS |
| TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| JP2010538071A (ja) * | 2007-09-07 | 2010-12-09 | セラヴァンス， インコーポレーテッド | 二重作用性降圧剤 |
| EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
| CN101896470B (zh) | 2007-12-11 | 2013-04-10 | 施万制药 | 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途 |
| EP2297113A1 (en) | 2008-04-29 | 2011-03-23 | Theravance, Inc. | Dual-acting antihypertensive agents |
| EP2334651A2 (en) * | 2008-07-24 | 2011-06-22 | Theravance, Inc. | Dual-acting antihypertensive agents |
| WO2011005674A1 (en) | 2009-07-07 | 2011-01-13 | Theravance, Inc. | Dual-acting pyrazole antihypertensive agents |
| ES2441419T3 (es) | 2009-07-22 | 2014-02-04 | Theravance, Inc. | Agentes antihipertensivos de doble acción basados en oxazol |
| JP2013517295A (ja) | 2010-01-19 | 2013-05-16 | セラヴァンス， インコーポレーテッド | 二重に作用するチオフェン、ピロール、チアゾールおよびフラン抗高血圧症薬 |
| NZ611528A (en) | 2010-12-15 | 2015-06-26 | Theravance Biopharma R & D Ip Llc | Neprilysin inhibitors |
| ME02295B (me) | 2010-12-15 | 2016-02-20 | Theravance Biopharma R&D Ip Llc | Inhibitori neprilizina |
| ES2564275T3 (es) | 2011-02-17 | 2016-03-21 | Theravance Biopharma R&D Ip, Llc | Derivados aminobutíricos sustituidos como inhibidores de neprilisina |
| CA2825737C (en) | 2011-02-17 | 2018-11-13 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
| ES2653215T3 (es) | 2011-05-31 | 2018-02-06 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina |
| CA2835281A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| CN103582630B (zh) | 2011-05-31 | 2016-08-17 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| CA2871292A1 (en) | 2012-05-31 | 2013-12-05 | Theravance Biopharma R&D Ip, Llc | Nitric oxide donor neprilysin inhibitors |
| EP2858650B1 (en) | 2012-06-08 | 2018-11-14 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| RS55967B1 (sr) | 2012-06-08 | 2017-09-29 | Theravance Biopharma R&D Ip Llc | Inhibitori neprilizina |
| BR112015002821B1 (pt) | 2012-08-08 | 2022-10-18 | Theravance Biopharma R&D Ip, Llc | Compostos inibidores de neprilisina e composição farmacêutica |
| RS56300B1 (sr) | 2013-03-05 | 2017-12-29 | Theravance Biopharma R&D Ip Llc | Inhibitori neprilizina |
| SG11201606057PA (en) | 2014-01-30 | 2016-08-30 | Theravance Biopharma R&D Ip Llc | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
| ES2718239T3 (es) | 2014-01-30 | 2019-06-28 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
| ES2923002T3 (es) | 2015-02-11 | 2022-09-22 | Theravance Biopharma R&D Ip Llc | Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina |
| RS61325B1 (sr) | 2015-02-19 | 2021-02-26 | Theravance Biopharma R&D Ip Llc | (2r,4r)-5-(5'-hloro-2'-fluorobifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentanska kiselina |
| HUE055546T2 (hu) | 2016-03-08 | 2021-12-28 | Theravance Biopharma R&D Ip Llc | Kristályos (2S,4R)-5-(5'-klór-2-fluor-[1,1'-bifenil]-4-il)-2-(etoximetil)-4-(3-hidroxi izoxazol-5-karboxamido)-2-metilpentánsav és alkalmazásaik |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3334095A (en) | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
| US3334091A (en) | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
| GB1525845A (en) | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
| IE50839B1 (en) | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
| EP0042100A1 (de) | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
| US4320057A (en) | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
| US4415496A (en) | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
| NZ204130A (en) | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
| GB2128984B (en) | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| US4552889A (en) | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
| US4692438A (en) | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
| US4584294A (en) | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
| GR861118B (en) | 1985-04-30 | 1986-08-18 | Lilly Co Eli | 7-substituted bicyclic pyrazolidinones |
| ZA874107B (sr) | 1986-06-13 | 1987-12-09 | ||
| US4973585A (en) | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
| ZA874106B (en) | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
| GB8629875D0 (en) | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
| US4824832A (en) | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| GB8926512D0 (en) | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
| WO1991009840A1 (en) | 1989-12-22 | 1991-07-11 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
| CA2053340C (en) | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5491143A (en) | 1990-10-18 | 1996-02-13 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE |
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| CA2057786C (en) | 1990-12-21 | 2002-06-18 | Gary A. Flynn | Amino and nitro containing tricyclic compounds useful as inhibitors or ace |
| US5208230A (en) | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| FR2679564A1 (fr) | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| CA2119019A1 (en) | 1991-09-16 | 1993-04-01 | Harry R. Davis | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
| EP0534363B1 (en) | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| AU657793B2 (en) | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| DE69317764T2 (de) | 1992-02-14 | 1998-07-30 | Merrell Pharmaceuticals Inc., Cincinnati, Ohio | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
| EP0640086B1 (en) | 1992-05-15 | 1999-08-04 | Merrell Pharmaceuticals Inc. | MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
| RU2124503C1 (ru) | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
| US5238932A (en) | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| KR0156780B1 (ko) * | 1993-06-11 | 1998-11-16 | 나이토 하루오 | 아미노산 유도체 |
| US5525723A (en) | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| ATE177098T1 (de) * | 1994-02-14 | 1999-03-15 | Merrell Pharma Inc | Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren |
| DE69531489T2 (de) * | 1994-03-24 | 2004-04-08 | Merrell Pharmaceuticals Inc., Cincinnati | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
-
2001
- 2001-08-08 GB GBGB0119305.1A patent/GB0119305D0/en not_active Ceased
-
2002
- 2002-03-04 UA UA20031110184A patent/UA75647C2/uk unknown
- 2002-04-03 DK DK02732549T patent/DK1381605T3/da active
- 2002-04-03 RS YUP-787/03A patent/RS50919B/sr unknown
- 2002-04-03 KR KR1020037013181A patent/KR100910929B1/ko not_active IP Right Cessation
- 2002-04-08 US US10/118,179 patent/US6602866B2/en not_active Expired - Lifetime
- 2002-04-10 GT GT200200069A patent/GT200200069A/es unknown
- 2002-04-10 PE PE2002000294A patent/PE20021079A1/es not_active Application Discontinuation
- 2002-04-10 MY MYPI20021326A patent/MY128226A/en unknown
- 2002-04-10 AR ARP020101321A patent/AR034307A1/es active IP Right Grant
- 2002-04-10 TW TW091107133A patent/TWI319764B/zh not_active IP Right Cessation
- 2002-04-10 UY UY27255A patent/UY27255A1/es not_active Application Discontinuation
-
2003
- 2003-07-08 TN TNPCT/EP2002/003668A patent/TNSN03083A1/en unknown
- 2003-09-11 ZA ZA200307096A patent/ZA200307096B/en unknown
- 2003-09-12 CR CR7074A patent/CR7074A/es not_active Application Discontinuation
- 2003-09-26 EC EC2003004782A patent/ECSP034782A/es unknown
- 2003-10-07 IL IL158289A patent/IL158289A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI319764B (en) | 2010-01-21 |
| US6602866B2 (en) | 2003-08-05 |
| ECSP034782A (es) | 2003-12-01 |
| CR7074A (es) | 2007-12-04 |
| DK1381605T3 (da) | 2005-05-09 |
| GB0119305D0 (en) | 2001-10-03 |
| UA75647C2 (en) | 2006-05-15 |
| KR100910929B1 (ko) | 2009-08-06 |
| YU78703A (sh) | 2006-05-25 |
| MY128226A (en) | 2007-01-31 |
| AR034307A1 (es) | 2004-02-18 |
| ZA200307096B (en) | 2004-09-06 |
| TNSN03083A1 (en) | 2005-12-23 |
| US20020193589A1 (en) | 2002-12-19 |
| IL158289A (en) | 2010-11-30 |
| KR20040008153A (ko) | 2004-01-28 |
| GT200200069A (es) | 2002-12-17 |
| PE20021079A1 (es) | 2003-02-19 |
| UY27255A1 (es) | 2002-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RS50919B (sr) | Derivati merkaptoacetilamida, postupak za njihovo pripremanje i njihova upotreba | |
| MXPA04001240A (es) | Analogos antitumorales. | |
| HRP20090266T1 (en) | Malonamide derivatives blocking the activity of gamma-secretase | |
| RS50378B (sr) | N-heterociklični derivati kao nos inhibitori | |
| RS50519B (sr) | Supstituisani derivati 8'-piri(mi)dinil-dihidrospiro- /cikloalkilamin/-pirimido/1,2-a/pirimidin-6-ona | |
| RS51674B (sr) | Derivati piperidin-4-il-piridazin-3-ilamina kao brzo disocirajući antagonisti dopamin 2 receptora | |
| RS53029B (sr) | Karbonilamino pirolopirazoli, snažni inhibitori kinaze | |
| HUP0300909A2 (hu) | NHE-3 inhibitor hatású 2-guanidino-4-aril-kinazolin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| RS50045B (sr) | Aktivatori glukokinaze | |
| CY1109835T1 (el) | Πυρανονες χρησιμες ως αναστολεις της atm | |
| ME00411B (me) | Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavistan od natrijuma | |
| HUP0101688A2 (hu) | Heterociklussal szubsztituált amidok és alkalmazásuk gyógyszerkészítmények előállítására | |
| HRP20070529T3 (en) | Imidazole derivatives as glutmate receptor antagonists | |
| HRP20000406B1 (en) | Arylpiperazines having activity at the serotonin 1a receptor | |
| RS51193B (sr) | Hidantoinski derivati korisni kao inhibitori metaloproteinaza | |
| CO4990933A1 (es) | Derivados de indazol triciclicos, su preparacion y su apli- cacion en terapeutica | |
| SE8003823L (sv) | Nya 3-formylmetylcefalosporiner och forfarande for framstellning derav | |
| RS51126B (sr) | Postupak za pripremanje mezilata piperazin derivata | |
| YU45582B (sh) | Postopek za pripravo derivatov arilamina | |
| YU52498A (sh) | UPOTREBA 2-ARILBENZO (b) TIOFENA ZA DOBIJANJE LEKA | |
| HRP20020440B1 (en) | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | |
| HRP20030823B1 (en) | Mercaptoacetylamide derivatives, a process for their preparation and their use | |
| DK1628968T3 (da) | 4-imidazolin-2-on-forbindelser | |
| HRP20030381B1 (en) | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A | |
| RS49829B (sr) | Postupak i intermedijeri za proizvodnju piridin-2,3-dikarboksilat jedinjenja |