PE20021079A1 - Derivados de mercaptoacetilamida y procedimiento para su preparacion - Google Patents
Derivados de mercaptoacetilamida y procedimiento para su preparacionInfo
- Publication number
- PE20021079A1 PE20021079A1 PE2002000294A PE2002000294A PE20021079A1 PE 20021079 A1 PE20021079 A1 PE 20021079A1 PE 2002000294 A PE2002000294 A PE 2002000294A PE 2002000294 A PE2002000294 A PE 2002000294A PE 20021079 A1 PE20021079 A1 PE 20021079A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- alkyl
- oxo
- procedure
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical class C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000003729 Neprilysin Human genes 0.000 abstract 1
- 108090000028 Neprilysin Proteins 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES H, -CH2OC(O)C(CH3)3, ACILO; R2 ES H, -CH2O-C(O)C(CH3)3, ALQUILO C1-C4, ARILO, ARIL-ALQUILO (C1-C4), DIFENILMETILO; X ES -(CH2)n DONDE n ES 0-1; -S-, -O-, -N(R3)-, ENTRE OTROS; R3 ES H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO (C1-C4), ENTRE OTROS; B1 Y B2 SON H, OH, OR5, DONDE R5 ES ALQUILO C1-C4, ARILO, ARILALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ESTER DIFENILMETILICO DEL ACIDO [4S-[4O, 7O(S), 12bß]]-7-[[2(R)-ACETILTIO-3-METIL-1-OXOBUTIL]AMINO]-1,2,3,4,6,7,8,12b-OCTAHIDRO-6-OXO-PIRIDO[2,1a][2]BENZAZEPINA-4-CARBOXILICO, ESTER DIFENILMETILICO DEL ACIDO [4S-[4O, 7O(S), 12bß]]-7-[[3-METIL-1-OXO-2(R)-TIOBUTIL]AMINO]-1,2,3,4,6,7,8,12b-OCTAHIDRO-6-OXO-PIRIDO[2,1a][2]BENZAZEPINA-4-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS DE FORMULA I INHIBEN LA ENZIMA CONVERTIDORA DE ANGIOTENSINA Y ENDOPEPTIDASA NEUTRA Y SON UTILES PARA EL TRATAMIENTO DE HIPERTENSION
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28330501P | 2001-04-12 | 2001-04-12 | |
GBGB0119305.1A GB0119305D0 (en) | 2001-04-12 | 2001-08-08 | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20021079A1 true PE20021079A1 (es) | 2003-02-19 |
Family
ID=23085405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000294A PE20021079A1 (es) | 2001-04-12 | 2002-04-10 | Derivados de mercaptoacetilamida y procedimiento para su preparacion |
Country Status (17)
Country | Link |
---|---|
US (1) | US6602866B2 (es) |
KR (1) | KR100910929B1 (es) |
AR (1) | AR034307A1 (es) |
CR (1) | CR7074A (es) |
DK (1) | DK1381605T3 (es) |
EC (1) | ECSP034782A (es) |
GB (1) | GB0119305D0 (es) |
GT (1) | GT200200069A (es) |
IL (1) | IL158289A (es) |
MY (1) | MY128226A (es) |
PE (1) | PE20021079A1 (es) |
RS (1) | RS50919B (es) |
TN (1) | TNSN03083A1 (es) |
TW (1) | TWI319764B (es) |
UA (1) | UA75647C2 (es) |
UY (1) | UY27255A1 (es) |
ZA (1) | ZA200307096B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003244467A1 (en) * | 2002-02-04 | 2003-09-02 | Kaneka Corporation | Process for production of optically active 2-halogeno- carboxylic acids |
TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
TWI406850B (zh) * | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
US7834041B2 (en) | 2007-09-07 | 2010-11-16 | Theravance, Inc. | Dual-acting antihypertensive agents |
AU2008350907A1 (en) | 2007-12-11 | 2009-08-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
WO2009076288A1 (en) | 2007-12-11 | 2009-06-18 | Theravance, Inc. | Dual-acting benzoimidazole derivative and their use as antihypertensive agents |
EP2297113A1 (en) | 2008-04-29 | 2011-03-23 | Theravance, Inc. | Dual-acting antihypertensive agents |
WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
JP5833000B2 (ja) | 2009-07-07 | 2015-12-16 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 二重に作用するピラゾール抗高血圧症薬 |
EP2456762B1 (en) | 2009-07-22 | 2013-10-16 | Theravance, Inc. | Dual-acting oxazole antihypertensive agents |
WO2011090929A1 (en) | 2010-01-19 | 2011-07-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
KR101892500B1 (ko) | 2010-12-15 | 2018-08-28 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 억제제 |
WO2012082857A1 (en) | 2010-12-15 | 2012-06-21 | Theravance, Inc. | Neprilysin inhibitors |
WO2012154249A1 (en) | 2011-02-17 | 2012-11-15 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
MY163394A (en) | 2011-02-17 | 2017-09-15 | Theravance Biopharma R&D Ip Llc | Substituted aminobutyric derivates as neprilysin inhibitors |
CA2835281A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
CN103582630B (zh) | 2011-05-31 | 2016-08-17 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
JP5959074B2 (ja) | 2011-05-31 | 2016-08-02 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤 |
TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
ES2609810T3 (es) | 2012-05-31 | 2017-04-24 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina donadores de óxido nítrico |
WO2013184934A1 (en) | 2012-06-08 | 2013-12-12 | Theravance, Inc. | Neprilysin inhibitors |
ES2710932T3 (es) | 2012-06-08 | 2019-04-29 | Theravance Biopharma R&D Ip Llc | Inhibidores de neprilisina |
PT2882716T (pt) | 2012-08-08 | 2017-03-13 | Theravance Biopharma R&D Ip Llc | Inibidores da neprilisina |
CA2902456A1 (en) | 2013-03-05 | 2014-09-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
CA2934936A1 (en) | 2014-01-30 | 2015-08-06 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
JP2017504625A (ja) | 2014-01-30 | 2017-02-09 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤としての5−ビフェニル−4−ヘテロアリールカルボニルアミノ−ペンタン酸誘導体 |
ES2923002T3 (es) | 2015-02-11 | 2022-09-22 | Theravance Biopharma R&D Ip Llc | Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina |
SI3259255T1 (sl) | 2015-02-19 | 2021-04-30 | Theravance Biopharma R&D Ip, Llc | (2R,4R)-5-(5'-kloro-2'-fluorobifenil-4-IL)-2-hidroksi-4-((5-metiloksa- zol-2-karbonil)amino)pentanojska kislina |
US10100021B2 (en) | 2016-03-08 | 2018-10-16 | Theravance Biopharma R&D Ip, Llc | Crystalline(2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof |
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US4584294A (en) | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
CA1274832A (en) | 1985-04-30 | 1990-10-02 | Richard Elmer Holmes | 7-substituted bicyclic pyrazolidinones |
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US5407960A (en) | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
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FR2679564A1 (fr) | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
AU2650692A (en) | 1991-09-16 | 1993-04-27 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
ES2106112T3 (es) | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
AU657793B2 (en) | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
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RU2124503C1 (ru) | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
CA2140553A1 (en) * | 1993-06-11 | 1994-12-22 | Hitoshi Oinuma | Amino acid derivative |
US5525723A (en) | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
WO1995021839A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
ATE246927T1 (de) * | 1994-03-24 | 2003-08-15 | Merrell Pharma Inc | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
-
2001
- 2001-08-08 GB GBGB0119305.1A patent/GB0119305D0/en not_active Ceased
-
2002
- 2002-03-04 UA UA20031110184A patent/UA75647C2/uk unknown
- 2002-04-03 RS YUP-787/03A patent/RS50919B/sr unknown
- 2002-04-03 DK DK02732549T patent/DK1381605T3/da active
- 2002-04-03 KR KR1020037013181A patent/KR100910929B1/ko not_active IP Right Cessation
- 2002-04-08 US US10/118,179 patent/US6602866B2/en not_active Expired - Lifetime
- 2002-04-10 TW TW091107133A patent/TWI319764B/zh not_active IP Right Cessation
- 2002-04-10 GT GT200200069A patent/GT200200069A/es unknown
- 2002-04-10 AR ARP020101321A patent/AR034307A1/es active IP Right Grant
- 2002-04-10 UY UY27255A patent/UY27255A1/es not_active Application Discontinuation
- 2002-04-10 PE PE2002000294A patent/PE20021079A1/es not_active Application Discontinuation
- 2002-04-10 MY MYPI20021326A patent/MY128226A/en unknown
-
2003
- 2003-07-08 TN TNPCT/EP2002/003668A patent/TNSN03083A1/en unknown
- 2003-09-11 ZA ZA200307096A patent/ZA200307096B/en unknown
- 2003-09-12 CR CR7074A patent/CR7074A/es not_active Application Discontinuation
- 2003-09-26 EC EC2003004782A patent/ECSP034782A/es unknown
- 2003-10-07 IL IL158289A patent/IL158289A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20020193589A1 (en) | 2002-12-19 |
GB0119305D0 (en) | 2001-10-03 |
MY128226A (en) | 2007-01-31 |
UA75647C2 (en) | 2006-05-15 |
IL158289A (en) | 2010-11-30 |
CR7074A (es) | 2007-12-04 |
ZA200307096B (en) | 2004-09-06 |
KR20040008153A (ko) | 2004-01-28 |
ECSP034782A (es) | 2003-12-01 |
KR100910929B1 (ko) | 2009-08-06 |
DK1381605T3 (da) | 2005-05-09 |
US6602866B2 (en) | 2003-08-05 |
AR034307A1 (es) | 2004-02-18 |
GT200200069A (es) | 2002-12-17 |
TWI319764B (en) | 2010-01-21 |
TNSN03083A1 (en) | 2005-12-23 |
RS50919B (sr) | 2010-08-31 |
UY27255A1 (es) | 2002-07-31 |
YU78703A (sh) | 2006-05-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |