ECSP034782A - Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso - Google Patents

Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso

Info

Publication number
ECSP034782A
ECSP034782A EC2003004782A ECSP034782A ECSP034782A EC SP034782 A ECSP034782 A EC SP034782A EC 2003004782 A EC2003004782 A EC 2003004782A EC SP034782 A ECSP034782 A EC SP034782A EC SP034782 A ECSP034782 A EC SP034782A
Authority
EC
Ecuador
Prior art keywords
preparation
derivatives
compounds
mercaptoacetilamide
procedure
Prior art date
Application number
EC2003004782A
Other languages
English (en)
Inventor
Wolfgang Linz
Heinz-Werner Kleemann
Gary A Flynn
Barbara A Anderson
Manfred Gerken
Bernd Jablonka
Werner Seiz
Bernhard Seuring
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of ECSP034782A publication Critical patent/ECSP034782A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere y reivindica series de derivados de mercaptoacetilamida de formula (I), también se describen y se reivindican las composiciones farmacéuticas que incorporan estos compuestos y procesos para la preparación de dichos compuestos. También se describe y se reivindica el uso de tales compuestos para la inhibición de las enzimas convertidoras de angiotensina y endopeptidasa neutra, y para el tratamiento de hipertensión e insuficiencia cardiaca congestiva.
EC2003004782A 2001-04-12 2003-09-26 Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso ECSP034782A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12

Publications (1)

Publication Number Publication Date
ECSP034782A true ECSP034782A (es) 2003-12-01

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004782A ECSP034782A (es) 2001-04-12 2003-09-26 Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso

Country Status (17)

Country Link
US (1) US6602866B2 (es)
KR (1) KR100910929B1 (es)
AR (1) AR034307A1 (es)
CR (1) CR7074A (es)
DK (1) DK1381605T3 (es)
EC (1) ECSP034782A (es)
GB (1) GB0119305D0 (es)
GT (1) GT200200069A (es)
IL (1) IL158289A (es)
MY (1) MY128226A (es)
PE (1) PE20021079A1 (es)
RS (1) RS50919B (es)
TN (1) TNSN03083A1 (es)
TW (1) TWI319764B (es)
UA (1) UA75647C2 (es)
UY (1) UY27255A1 (es)
ZA (1) ZA200307096B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066563A1 (en) * 2002-02-04 2003-08-14 Kaneka Corporation Process for production of optically active 2-halogeno- carboxylic acids
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) * 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
US7834041B2 (en) * 2007-09-07 2010-11-16 Theravance, Inc. Dual-acting antihypertensive agents
CN101896470B (zh) 2007-12-11 2013-04-10 施万制药 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
EP2297113A1 (en) 2008-04-29 2011-03-23 Theravance, Inc. Dual-acting antihypertensive agents
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
US7956054B2 (en) 2009-07-07 2011-06-07 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
ES2441419T3 (es) 2009-07-22 2014-02-04 Theravance, Inc. Agentes antihipertensivos de doble acción basados en oxazol
EP2526095A1 (en) 2010-01-19 2012-11-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
KR101892611B1 (ko) 2010-12-15 2018-08-28 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
JP5944921B2 (ja) 2010-12-15 2016-07-05 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
MX342212B (es) 2011-02-17 2016-09-20 Theravance Inc Inhibidores de neprilisina.
ES2564275T3 (es) 2011-02-17 2016-03-21 Theravance Biopharma R&D Ip, Llc Derivados aminobutíricos sustituidos como inhibidores de neprilisina
CN103748070B (zh) 2011-05-31 2015-06-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
CA2835220A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
KR102102197B1 (ko) 2012-06-08 2020-04-20 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
SMT201700134T1 (it) 2012-08-08 2017-05-08 Theravance Biopharma R&D Ip Llc Inibitori della neprilisina
DK2964616T3 (en) 2013-03-05 2017-08-28 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
SG11201606057PA (en) 2014-01-30 2016-08-30 Theravance Biopharma R&D Ip Llc 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
SG11201605965UA (en) 2014-01-30 2016-08-30 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
BR112017017317B1 (pt) 2015-02-11 2023-02-14 Theravance Biopharma R&D Ip, Llc Composto, forma cristalina, composições farmacêuticas, forma de dosagem oral ou intravenosa, processos para a preparação do composto ou da forma cristalina e uso
MY191183A (en) 2015-02-19 2022-06-04 Theravance Biopharma R&D Ip Llc (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
MX377177B (es) 2016-03-08 2025-03-07 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5'-cloro-2'-fluoro-[1,1'-bifenil]-4-il)-2-(etoximetil)-4-(3-hidroxiisoxazol-5-carboxamido)-2-metilpentanoico cristalino, y sus usos.

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2128984B (en) 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
ZA833214B (en) 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
US4552889A (en) 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
GR861118B (en) 1985-04-30 1986-08-18 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
ZA874107B (es) 1986-06-13 1987-12-09
US4973585A (en) 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874106B (en) 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
GB8629875D0 (en) 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5527795A (en) 1990-10-18 1996-06-18 Merrell Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
CA2053340C (en) 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
DK0492369T3 (da) 1990-12-21 1997-10-13 Merrell Pharma Inc Hidtil ukendte tricycliske amino- og nitro-forbindelser med ACE-hæmmende virkning
US5208230A (en) 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
EP0605589A1 (en) 1991-09-16 1994-07-13 Schering Corporation Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
AU657793B2 (en) 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (en) 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
HU220596B1 (hu) 1992-02-14 2002-03-28 Merrell Dow Pharmaceuticals Inc. 7-Szubsztituált pirido-benzazepin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HU223663B1 (hu) 1992-05-15 2004-11-29 Merrel Dow Pharmaceuticals Inc. Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2140553A1 (en) * 1993-06-11 1994-12-22 Hitoshi Oinuma Amino acid derivative
US5525723A (en) 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
EP0745080B1 (en) * 1994-02-14 1999-03-03 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
AU688012B2 (en) * 1994-03-24 1998-03-05 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives

Also Published As

Publication number Publication date
US6602866B2 (en) 2003-08-05
CR7074A (es) 2007-12-04
RS50919B (sr) 2010-08-31
TNSN03083A1 (en) 2005-12-23
UY27255A1 (es) 2002-07-31
DK1381605T3 (da) 2005-05-09
KR20040008153A (ko) 2004-01-28
GB0119305D0 (en) 2001-10-03
IL158289A (en) 2010-11-30
PE20021079A1 (es) 2003-02-19
KR100910929B1 (ko) 2009-08-06
UA75647C2 (en) 2006-05-15
AR034307A1 (es) 2004-02-18
TWI319764B (en) 2010-01-21
YU78703A (sh) 2006-05-25
US20020193589A1 (en) 2002-12-19
ZA200307096B (en) 2004-09-06
MY128226A (en) 2007-01-31
GT200200069A (es) 2002-12-17

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