UY27255A1 - Derivados de mercaptoacetilamida , procedimiento para su preparacinn y su uso - Google Patents

Derivados de mercaptoacetilamida , procedimiento para su preparacinn y su uso

Info

Publication number
UY27255A1
UY27255A1 UY27255A UY27255A UY27255A1 UY 27255 A1 UY27255 A1 UY 27255A1 UY 27255 A UY27255 A UY 27255A UY 27255 A UY27255 A UY 27255A UY 27255 A1 UY27255 A1 UY 27255A1
Authority
UY
Uruguay
Prior art keywords
derivatives
compounds
mercaptoacetilamide
procedure
preparation
Prior art date
Application number
UY27255A
Other languages
English (en)
Inventor
Gary A Flynn
Shujaath Mehdi
Jack Roger Koehl
Barbara Ann Anderson
Dr Manfred Gerken
Dr Bernd Jablonka
Dr Heinz-Wermer Kleemann
Dr Wolfgang Linz
Dr Werner Seiz
Dr Bernhard Seuring
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of UY27255A1 publication Critical patent/UY27255A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención describe y reivindica una serie de derivados de mercaptoacetilamida de fórmula 1 . Asimismo se describen y reivindican composiciones farmacéuticas que incorporan estos compuestos, y procedimientos para preparar dichos compuestos. El uso de dichos compuestos para la inhibición de la enzimas convertidora de angiotensina y endopeptidasa neutra, y para el tratamiento de la hipertención y de la insuficiencia cardiaca congestiva, también se describen y reivindican.
UY27255A 2001-04-12 2002-04-10 Derivados de mercaptoacetilamida , procedimiento para su preparacinn y su uso UY27255A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12

Publications (1)

Publication Number Publication Date
UY27255A1 true UY27255A1 (es) 2002-07-31

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27255A UY27255A1 (es) 2001-04-12 2002-04-10 Derivados de mercaptoacetilamida , procedimiento para su preparacinn y su uso

Country Status (17)

Country Link
US (1) US6602866B2 (es)
KR (1) KR100910929B1 (es)
AR (1) AR034307A1 (es)
CR (1) CR7074A (es)
DK (1) DK1381605T3 (es)
EC (1) ECSP034782A (es)
GB (1) GB0119305D0 (es)
GT (1) GT200200069A (es)
IL (1) IL158289A (es)
MY (1) MY128226A (es)
PE (1) PE20021079A1 (es)
RS (1) RS50919B (es)
TN (1) TNSN03083A1 (es)
TW (1) TWI319764B (es)
UA (1) UA75647C2 (es)
UY (1) UY27255A1 (es)
ZA (1) ZA200307096B (es)

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EP2714648B1 (en) 2011-05-31 2017-08-16 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
CN103582630B (zh) 2011-05-31 2016-08-17 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
EP2855464B1 (en) 2012-05-31 2016-10-26 Theravance Biopharma R&D IP, LLC Nitric oxide donor neprilysin inhibitors
WO2013184934A1 (en) 2012-06-08 2013-12-12 Theravance, Inc. Neprilysin inhibitors
JP6162229B2 (ja) 2012-06-08 2017-07-12 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
HUE031301T2 (hu) 2012-08-08 2017-07-28 Theravance Biopharma R&D Ip Llc Neprilizin inhibitorok
US8901169B2 (en) 2013-03-05 2014-12-02 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
US9585882B2 (en) 2014-01-30 2017-03-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
KR20160113291A (ko) 2014-01-30 2016-09-28 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프리리신 저해제
KR102640906B1 (ko) 2015-02-11 2024-02-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산
CN107250119B (zh) 2015-02-19 2020-09-22 施万生物制药研发Ip有限责任公司 (2r,4r)-5-(5′-氯-2′-氟联苯-4-基)-2-羟基-4-[(5-甲基恶唑-2-羰基)氨基]戊酸
TWI731943B (zh) 2016-03-08 2021-07-01 美商施萬生物製藥研發Ｉｐ有限責任公司 結晶型（2s，4r）－5－（5’－氯－2’－氟－［1，1’－聯苯］－4－基）－2－（乙氧基甲基）－4－（3－羥基異㗁唑－5－甲醯胺基）－2－甲基戊酸及其用途

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Also Published As

Publication number Publication date
UA75647C2 (en) 2006-05-15
PE20021079A1 (es) 2003-02-19
CR7074A (es) 2007-12-04
TWI319764B (en) 2010-01-21
GT200200069A (es) 2002-12-17
KR20040008153A (ko) 2004-01-28
YU78703A (sh) 2006-05-25
TNSN03083A1 (en) 2005-12-23
AR034307A1 (es) 2004-02-18
DK1381605T3 (da) 2005-05-09
MY128226A (en) 2007-01-31
RS50919B (sr) 2010-08-31
ECSP034782A (es) 2003-12-01
GB0119305D0 (en) 2001-10-03
IL158289A (en) 2010-11-30
US6602866B2 (en) 2003-08-05
ZA200307096B (en) 2004-09-06
KR100910929B1 (ko) 2009-08-06
US20020193589A1 (en) 2002-12-19

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Legal Events

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Effective date: 20141217