HUP0101688A2 - Heterociklussal szubsztituált amidok és alkalmazásuk gyógyszerkészítmények előállítására - Google Patents

Heterociklussal szubsztituált amidok és alkalmazásuk gyógyszerkészítmények előállítására

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Publication number
HUP0101688A2
HUP0101688A2 HU0101688A HUP0101688A HUP0101688A2 HU P0101688 A2 HUP0101688 A2 HU P0101688A2 HU 0101688 A HU0101688 A HU 0101688A HU P0101688 A HUP0101688 A HU P0101688A HU P0101688 A2 HUP0101688 A2 HU P0101688A2
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group
ring
alkyl
nhco
optionally
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HU0101688A
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Monika Knopp
Wilfried Lubisch
Achim Möller
Hans-Jörg Treiber
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Basf Ag
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Publication of HUP0101688A2 publication Critical patent/HUP0101688A2/hu
Publication of HUP0101688A3 publication Critical patent/HUP0101688A3/hu

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A—HUMAN NECESSITIES
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

A találmány tárgyát az általános képletű amidok - ahol R1 adottesetben szubsztituált, adott esetben gyűrűtag heteroatomot tartalmazóaromás csoport, R2 halogénatom, alkil-, alkenil-, alkinil-, alkil-fenil-, alkenil-fenil-csoport, alkinil-fenil-csoport, fenil-, NHCO-alkil-, NHSO2-alkil-, NHCO-fenil-, nitro-, alkoxi- és aminocsoport,ahol az aromás gyűrűk maguk is további egy-két szubsztituensthordozhatnak, és két R2 csoport együtt - CH=CH-CH=CH-láncot isjelenthet, azaz a két R2 csoport együtt adott esetben szubsztituáltanellált benzogyűrűt is képezhet, R3 alkilcsoport, amelyet adottesetben metil-tio-, fenil-, ciklohexil-, cikloheptil-, ciklopentil-,indolil-, piridil- vagy naftilcsoport szubsztituálhat, ahol a gyűrűscsoportok maguk is szubsztituáltak lehetnek, X-(CH2)m-, -(CH2)m-O-(-(CH2)o-, -(CH2)o-S-(CH2)m-, -(CH2)o-SO-(CH2)m-, -(CH2)o-SO2-(CH2)m-,etenilén-, etinilén-, -CO-CH=CH-, -(CH2)o-CO-(CH2)m-, -(CH2)m-NHCO-(CH2)o-, -(CH2)m-CONH-(CH2)o-, -(CH2)m-NHSO2-(CH2)o-, -NH-CO-CH=CH-, -(CH2)m-SO2NH-(CH2)o-, -CONH-csoport, és általános képletű csoport, R1és X együtt (általános) képletű vegyületet is jelenthet, Y telítetlenheterociklusos csoport, és R4 hidrogénatom, -COOR6 és -CO-Z általánosképletű csoport, ahol Z jelentése mono- vagy dialkil-amino-csoport, és5- vagy 6-tagú, egy vagy két gyűrűtag aminocsoportot tartalmazó gyűrűscsoport, n értéke 0, 1 vagy 2, és m, o értéke egymástól függetlenül 0,1, 2, 3 vagy 4 -és tautomer és izomer formáik, lehetséges enantiomervagy diasztereomer formáik, valamint fiziológiailag elfogadható sóik,előállításuk és kalpaint-inhibitorként történő alkalmazásuk képezik. Ó
HU0101688A 1998-04-20 1999-04-19 Heterocyclically substituted amides and their use for producing pharmaceutical compositions HUP0101688A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19817459A DE19817459A1 (de) 1998-04-20 1998-04-20 Neue heterozyklische substituierte Amide, Herstellung und Anwendung
PCT/EP1999/002611 WO1999054304A1 (de) 1998-04-20 1999-04-19 Heterozyklische substituierte amide, deren herstellung und anwendung

Publications (2)

Publication Number Publication Date
HUP0101688A2 true HUP0101688A2 (hu) 2001-11-28
HUP0101688A3 HUP0101688A3 (en) 2002-12-28

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HU0101688A HUP0101688A3 (en) 1998-04-20 1999-04-19 Heterocyclically substituted amides and their use for producing pharmaceutical compositions

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US (2) US6630493B1 (hu)
EP (1) EP1073638B1 (hu)
JP (1) JP4621350B2 (hu)
KR (1) KR20010042841A (hu)
CN (1) CN1301255A (hu)
AT (1) ATE402149T1 (hu)
AU (1) AU3927199A (hu)
BG (1) BG104831A (hu)
BR (1) BR9909772A (hu)
CA (1) CA2328438C (hu)
DE (2) DE19817459A1 (hu)
ES (1) ES2310937T3 (hu)
HR (1) HRP20000786A2 (hu)
HU (1) HUP0101688A3 (hu)
ID (1) ID26980A (hu)
IL (1) IL138704A0 (hu)
NO (1) NO20005264D0 (hu)
PL (1) PL343467A1 (hu)
SK (1) SK14522000A3 (hu)
TR (1) TR200003056T2 (hu)
WO (1) WO1999054304A1 (hu)
ZA (1) ZA200006718B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID26403A (id) * 1998-04-20 2000-12-21 Basf Ag Amida baru yang tersubstitusi, pembuatan dan penggunaannya
IL138402A0 (en) * 1998-04-20 2001-10-31 Basf Ag Heterocyclically substituted amides used as calpain inhibitors
CN1303372A (zh) * 1998-05-25 2001-07-11 Basf公司 新的杂环取代酰胺、其制备以及应用
ATE312820T1 (de) * 1999-10-28 2005-12-15 Trine Pharmaceuticals Inc Pumpeninhibitoren zur freisetzung von medikamenten
DE10114762A1 (de) * 2001-03-26 2002-10-02 Knoll Gmbh Verwendung von Cysteinprotease-Inhibitoren
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
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NO20005264L (no) 2000-10-19
WO1999054304A1 (de) 1999-10-28
EP1073638A1 (de) 2001-02-07
ATE402149T1 (de) 2008-08-15
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CA2328438A1 (en) 1999-10-28
CA2328438C (en) 2011-02-22
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ID26980A (id) 2001-02-22
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