CN1993355A - 奥美沙坦酯的纯化方法 - Google Patents

奥美沙坦酯的纯化方法 Download PDF

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Publication number
CN1993355A
CN1993355A CNA2005800262573A CN200580026257A CN1993355A CN 1993355 A CN1993355 A CN 1993355A CN A2005800262573 A CNA2005800262573 A CN A2005800262573A CN 200580026257 A CN200580026257 A CN 200580026257A CN 1993355 A CN1993355 A CN 1993355A
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CN
China
Prior art keywords
olmesartan medoxomill
solution
acid
olmesartan
water
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Pending
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CNA2005800262573A
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English (en)
Chinese (zh)
Inventor
L·赫德瓦蒂
G·皮拉斯基
Y·赖兹
E·马罗姆
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Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CN1993355A publication Critical patent/CN1993355A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2005800262573A 2004-09-02 2005-09-02 奥美沙坦酯的纯化方法 Pending CN1993355A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60643704P 2004-09-02 2004-09-02
US60/606,437 2004-09-02
US60/638,736 2004-12-22

Publications (1)

Publication Number Publication Date
CN1993355A true CN1993355A (zh) 2007-07-04

Family

ID=35462159

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005800262573A Pending CN1993355A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的纯化方法
CNA2005800219037A Pending CN1976926A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的制备

Family Applications After (1)

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CNA2005800219037A Pending CN1976926A (zh) 2004-09-02 2005-09-02 奥美沙坦酯的制备

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US (1) US7528258B2 (enExample)
EP (1) EP1706401A1 (enExample)
JP (1) JP4511550B2 (enExample)
CN (2) CN1993355A (enExample)
CA (1) CA2573800A1 (enExample)
IL (1) IL181549A0 (enExample)
WO (1) WO2006029056A1 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102414200A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 奥美沙坦酯的制备方法
CN102414201A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 新型溶剂化物晶体
CN102459243A (zh) * 2009-05-20 2012-05-16 兰贝克赛实验室有限公司 奥美沙坦酯制造工艺
CN102558161A (zh) * 2011-12-07 2012-07-11 浙江华海药业股份有限公司 一种采用丙酮与水混合液精制奥美沙坦酯的工艺
CN102584804A (zh) * 2011-12-13 2012-07-18 浙江华海药业股份有限公司 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺
US8735598B2 (en) 2008-06-09 2014-05-27 Daiichi Sankyo Company, Limited Method for producing 1-biphenylmethylimidazole compound
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
CN108658954A (zh) * 2018-06-12 2018-10-16 广州小桔生物科技有限公司 一种高纯度奥美沙坦酯的精制方法
CN109761966A (zh) * 2019-01-30 2019-05-17 浙江省食品药品检验研究院 一种奥美沙坦酯晶体及其制备方法

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EA014026B1 (ru) * 2005-07-29 2010-08-30 Крка, Товарна Здравил, Д.Д., Ново Место Способ получения олмесартан медоксомила
EP1816131A1 (en) * 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
EP2022790A1 (en) * 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. A process for the preparation or purification of olmesartan medoxomil
CA2707365A1 (en) 2007-08-08 2009-02-12 Lek Pharmaceuticals D.D. A process for the preparation of olmesartan medoxomil
WO2011014611A2 (en) * 2009-07-30 2011-02-03 Dr. Reddy's Laboratories Ltd. Preparation of olmesartan medoxomil
CA2769704A1 (en) * 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Polymorphic form of olmesartan medoxomil
EP2409710A1 (en) 2010-06-29 2012-01-25 NanotecMARIN GmbH Injectable material and material to be used as drug or food supplement for prophylaxis or treatment of osteoporosis
EP2409682A1 (en) 2010-07-19 2012-01-25 Werner E. G. MÜLLER Hydroxyapatite-binding nano- and microparticles for caries prophylaxis and reduction of dental hypersensitivity
KR101266224B1 (ko) 2010-09-02 2013-05-21 일동제약주식회사 트리틸 올메사르탄 메독소밀의 개선된 제조방법
CZ2010785A3 (cs) 2010-10-29 2012-05-16 Zentiva, K.S. Zpusob výroby olmesartanu medoxomilu
AR083523A1 (es) 2010-10-29 2013-03-06 Interquim Sa Procedimiento de obtencion del olmesartan medoxomilo
EP2489346A1 (en) 2011-01-26 2012-08-22 NanotecMARIN GmbH Food supplement and injectable material for prophylaxis and therapy of osteoporosis and other bone diseases
EP2739619B1 (en) 2011-08-05 2015-09-16 Lupin Limited Process for the preparation of olmesartan medoxomil
WO2014036686A1 (zh) * 2012-09-04 2014-03-13 上海迪赛诺化学制药有限公司 奥美沙坦酯的制备方法
CN111170946B (zh) * 2020-03-16 2022-02-11 浙江华洲药业有限公司 一种奥美沙坦中间体的合成方法

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US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
DE4036706A1 (de) 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
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JP4260241B2 (ja) 1998-04-21 2009-04-30 第一三共株式会社 イミダゾール誘導体の製造法
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DK1535901T3 (da) 2002-06-12 2008-04-07 Sumitomo Chemical Co Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl
CN1271068C (zh) 2003-03-25 2006-08-23 上海医药工业研究院 一种奥美沙坦酯的制备方法
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8735598B2 (en) 2008-06-09 2014-05-27 Daiichi Sankyo Company, Limited Method for producing 1-biphenylmethylimidazole compound
CN102414201B (zh) * 2009-04-28 2015-10-14 第一三共株式会社 溶剂化物晶体
CN102414201A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 新型溶剂化物晶体
CN102414200A (zh) * 2009-04-28 2012-04-11 第一三共株式会社 奥美沙坦酯的制备方法
US8859600B2 (en) 2009-04-28 2014-10-14 Daiichi Sankyo Company, Limited Acetone solvate crystals of trityl olmesartan medoxomil
CN102414200B (zh) * 2009-04-28 2014-12-17 第一三共株式会社 奥美沙坦酯的制备方法
US8933241B2 (en) 2009-04-28 2015-01-13 Daiichi Sankyo Company, Limited Method for producing olmesartan medoxomil
CN102459243A (zh) * 2009-05-20 2012-05-16 兰贝克赛实验室有限公司 奥美沙坦酯制造工艺
CN102558161A (zh) * 2011-12-07 2012-07-11 浙江华海药业股份有限公司 一种采用丙酮与水混合液精制奥美沙坦酯的工艺
CN102558161B (zh) * 2011-12-07 2016-07-06 浙江华海药业股份有限公司 一种采用丙酮与水混合液精制奥美沙坦酯的工艺
CN102584804A (zh) * 2011-12-13 2012-07-18 浙江华海药业股份有限公司 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺
CN102584804B (zh) * 2011-12-13 2016-05-18 浙江华海药业股份有限公司 一种三苯甲基奥美沙坦酯脱保护基制备奥美沙坦酯的工艺
US9273026B2 (en) 2012-07-20 2016-03-01 Novartis Ag Carbamate/urea derivatives
US9034874B2 (en) 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
US9624192B2 (en) 2012-07-20 2017-04-18 Novartis Ag Carbamate/urea derivatives
CN108658954A (zh) * 2018-06-12 2018-10-16 广州小桔生物科技有限公司 一种高纯度奥美沙坦酯的精制方法
CN109761966A (zh) * 2019-01-30 2019-05-17 浙江省食品药品检验研究院 一种奥美沙坦酯晶体及其制备方法

Also Published As

Publication number Publication date
IL181549A0 (en) 2007-07-04
US20060069141A1 (en) 2006-03-30
EP1706401A1 (en) 2006-10-04
CN1976926A (zh) 2007-06-06
CA2573800A1 (en) 2006-03-16
JP2007509992A (ja) 2007-04-19
JP4511550B2 (ja) 2010-07-28
WO2006029056A1 (en) 2006-03-16
US7528258B2 (en) 2009-05-05

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