CN1902162A - 酰氨基乙腈衍生物 - Google Patents
酰氨基乙腈衍生物 Download PDFInfo
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- CN1902162A CN1902162A CNA2004800399139A CN200480039913A CN1902162A CN 1902162 A CN1902162 A CN 1902162A CN A2004800399139 A CNA2004800399139 A CN A2004800399139A CN 200480039913 A CN200480039913 A CN 200480039913A CN 1902162 A CN1902162 A CN 1902162A
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- Prior art keywords
- compound
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- cyano group
- methyl
- ethyl
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
1.齐墩螨素(Abamectin) | 94.噻螨酮(Hexythiazox) |
2.AC 303 630 | 95.蒙五一二(Hydroprene) |
3.乙酰甲胺磷(Acephat) | 96.吡虫啉(Imidacloprid) |
4.氟酯菊酯(Acrinathrin) | 97.对昆虫有活性的真菌 |
5.棉铃威(Alanycarb) | 98.对昆虫有活性的线虫 |
6.涕灭威(Aldicarb) | 99.对昆虫有活性的病毒 |
7.氯氰菊酯(α-Cypermethrin) | 100.异道瘟净(Iprobenfos) |
8.甲体氯氰菊酯(Alphamethrin) | 101.丙胺磷(Isofenphos) |
9.虫螨脒(Amitraz) | 102.异丙威(Isoprocarb) |
10.阿维菌素(Avermectin B1) | 103.异恶唑磷(Isoxathion) |
11.AZ 60541 | 104.伊维菌素(Ivermectin) |
12.谷硫磷A(Azinphos A) | 105.氯氟氰菊酯(λ-Cyhalothrin) |
13.谷硫磷M(Azinphos M) | 106.氟丙氧脲(Lufenuron) |
14.唑环锡(Azocyclotin) | 107.马拉硫磷(Malathion) |
15.枯草芽孢杆菌毒素(Bacillus subtil.toxin) | 108.灭蚜磷(Mecarbam) |
16.虫威(Bendiocarb) | 109.甲亚砜磷(Mesulfenfos) |
17.丙硫克百威(Benfuracarb) | 110.多聚乙醛(Metaldehyd) |
18.杀虫磺(Bensultap) | 111.甲胺磷(Methamidophos) |
19.β氟氯氰菊酯(β-Cyfluthrin) | 112.灭虫威(Methiocarb) |
20.氟氯菊酯(Bifenthrin) | 113.灭多虫(Methomyl) |
21.BPMC | 114.蒙五一五(Methoprene) |
22.Brofenprox | 115.速灭威(Metolcarb) |
23.溴硫磷A(Bromophos A) | 116.速灭磷(Mevinphos) |
24.合杀威(Bufencarb) | 117.米尔螨素(Milbemectin) |
25.噻嗪酮(Buprofezin) | 118.Moxidectin |
26.Butocarboxin | 119.二溴磷(Naled) |
27.丁基哒螨灵(Butylpyridaben) | 120.NC 184 |
28.硫线磷(Cadusafos) | 121.NI-25,吡虫清(Acetamiprid) |
29.甲萘威(Carbaryl) | 122.硝胺烯啶(Nitenpyram) |
30.克百威(Carbofuran) | 123.氧化乐果(Omethoat) |
31.三硫磷(Carbophenthion) | 124.甲氨叉威(Oxamyl) |
32.杀螟丹(Cartap) | 125.砜吸磷(Oxydemethon M) |
33.除线威(Cloethocarb) | 126.异砜磷(Oxydeprofos) |
34.壤虫氯磷(Chlorethoxyfos) | 127.对硫磷(Parathion) |
35.氟唑虫清(Chlorfenapyr) | 128.甲基对硫磷(Parathion-methyl) |
36.啶虫隆(Chlorfluazuron) | 129.氯菊酯(Permethrin) |
37.氯甲磷(Chlormephos) | 130.稻丰散(Phenthoat) |
38.毒死蜱(Chlorpyrifs) | 131.甲拌磷(Phorat) |
39.顺式苄呋菊酯(Cis-Resmethrin) | 132.伏杀磷(Phosalone) |
40.三氟氯氰菊酯(Clocythrin) | 133.亚胺硫磷(Phosmet) |
41.四螨嗪(Clofentezin) | 134.辛硫磷(Phoxim) |
42.杀螟腈(Cyanophos) | 135.抗蚜威(Pirimicarb) |
43.乙氰菊酯(Cycloprothrin) | 136.Pirimiphos A |
44.氟氯氰菊酯(Cyfluthrin) | 137.虫螨磷M(Pirimiphos M) |
45.三环锡(Cyhexatin) | 138.猛杀威(Promecarb) |
46.D 234l | 139.丙虫磷(Propaphos) |
47.溴氰菊酯(Deltamethrin) | 140.残杀威(Propoxur) |
48.甲基内吸磷(Demeton M) | 141.丙硫磷(Prothiofos) |
49.内吸磷硫赶式异构体(Demeton S) | 142.发果(Prothoat) |
50.甲基内吸磷(Demeton-S-methyl) | 143.吡唑硫磷(Pyrachlofbs) |
51.除线磷(Dichlofenthion) | 144.Pyradaphenthion |
52.Dicliphos | 145.反灭虫菊(Pyresmethrin) |
53.乙硫磷(Diethion) | 146.除虫菊(Pyrethrum) |
54.氟脲杀(Diflubenzuron) | 147.哒螨酮(Pyridaben) |
55.乐果(Dimethoat) | 148.嘧胺苯醚(Pyrimidifen) |
56.甲基毒虫畏(Dimethylvinphos) | 149.蚊蝇醚(Pyriproxyfen) |
57.敌恶磷(Dioxathion) | 150.RH 5992 |
58.DPX-MP062 | 151.RH-2485 |
59.克瘟散(Edifenphos) | 152.蔬果磷(Salithion) |
60.甲氨基阿维菌素B1(Emamectin) | 153.硫线磷(Sebufos) |
61.硫丹(Endosulfan) | 154.灭虫硅醚(Silafluofen) |
62.高氰戊菊酯(Esfenvalerat) | 155.艾克敌105(Spinosad) |
63.苯虫成(Ethiofencarb) | 156.治螟磷(Sulfotep) |
64.乙硫磷(Ethion) | 157.乙丙硫磷(Sulprofos) |
65.醚菊酯(Ethofenprox) | 158.双苯酰肼(Tebufenozide) |
66.灭克磷(Ethoprophos) | 159.吡螨胺(Tebufenpyrad) |
67.氧嘧啶磷(Etrimfos) | 160.嘧丙磷(Tebupirimphos) |
68.克线磷(Fenamiphos) | 161.伏虫隆(Teflubenzuron) |
69.喹螨醚(Fenazaquin) | 162.七氟菊酯(Tefluthrin) |
70.杀螨锡(Fenbutatinoxid) | 163.双硫磷(Temephos) |
71.杀螟硫磷(Fenitrothion) | 164.叔丁威(Terbam) |
72.丁苯威(Fenobucarb) | 165.特丁磷(Terbufos) |
73.苯硫威(Fenothiocarb) | 166.杀虫畏(Tetrachlorvinphos) |
74.双氧威(Fenoxycarb) | 167.Thiafenox |
75.甲氰菊酯(Fenpropathrin) | 168.硫双威(Thiodicarb) |
76.Fenpyrad | 169.特氨叉威(Thiofanox) |
77.唑螨酯(Fenpyroximate) | 170.硫磷嗪(Thionazin) |
78.倍硫磷(Fenthion) | 171.敌贝特(Thuringiensin) |
79.杀灭菊酯(Fenvalerate) | 172.四溴菊酯(Tralomethrin) |
80.锐劲特(Fipronil) | 173.苯噻螨(Triarathene) |
81.氟啶胺(Fluazinam) | 174.唑蚜威(Triazamate) |
82.氟啶蜱脲(Fluazuron) | 175.三唑磷(Triazophos) |
83.氟螨脲(Flucycloxuron) | 176.Triazuron |
84.氟氰戊菊酯(Flucythrinat) | 177.敌百虫(Trichlorfon) |
85.氟虫脲(Flufenoxuron) | 178.杀虫隆(Triflumuron) |
86.氟丙苄醚(Flufenprox) | 179.混杀威(Trimethacarb) |
87.地虫磷(Fonofos) | 180.蚜灭多(Vamidothion) |
88.安果(Formothion) | 181.XMC(3,5-二甲苯基甲基氨基甲酸酯) |
89.噻唑酮磷(Fosthiazat) | 182.灭杀威(Xylylcarb) |
90.Fubfenprox | 183.YI 5301/5302 |
91.HCH | 184.氯氰菊酯(ξ-Cypermethrin) |
92.庚虫磷(Heptenophos) | 185.Zetamethrin |
93.氟铃脲(Hexaflumuron) |
No. | X | Q | 物理数据 |
1.1 | Cl | 4-CN | m.p.:147-9° |
1.2 | Br | 4-CN | |
1.3 | CF3 | 4-CN | m.p.:184-6° |
1.4 | Cl | 5-CN | m.p.:147-9° |
1.5 | Br | 5-CN | |
1.6 | CF3 | 5-CN | m.p.:154° |
No. | X | Q | 物理数据 |
2.1 | Cl | 4-CN | m.p.:60-2° |
2.2 | Br | 4-CN | |
2.3 | CF3 | 4-CN | m.p.:80-2° |
2.4 | Cl | 5-CN | m.p.:132-4° |
2.5 | Br | 5-CN | |
2.6 | CF3 | 5-CN | m.p.:75-8° |
No. | X | Y | Q | 物理数据 |
3.1 | Cl | S | 4-CN | m.p.:167-9° |
3.2 | Cl | SO | 4-CN | |
3.3 | Cl | SO2 | 4-CN | |
3.4 | Br | S | 4-CN | |
3.5 | Br | SO | 4-CN | |
3.6 | Br | SO2 | 4-CN | |
3.7 | CF3 | S | 4-CN | m.p.:79-82° |
3.8 | CF3 | SO | 4-CN | |
3.9 | CF3 | SO2 | 4-CN | |
3.10 | Cl | S | 5-CN | m.p.:125-7° |
3.11 | Cl | SO | 5-CN | |
3.12 | Cl | SO2 | 5-CN | |
3.13 | Br | S | 5-CN | |
3.14 | Br | SO | 5-CN | |
3.15 | Br | SO2 | 5-CN | |
3.16 | CF3 | S | 5-CN | m.p.:69-73° |
3.17 | CF3 | SO | 5-CN | |
3.18 | CF3 | SO2 | 5-CN | m.p.:80-100° |
Claims (29)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025290.2 | 2003-11-06 | ||
EP03025290 | 2003-11-06 | ||
GB0402677.9 | 2004-02-06 | ||
GBGB0402677.9A GB0402677D0 (en) | 2003-11-06 | 2004-02-06 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1902162A true CN1902162A (zh) | 2007-01-24 |
CN100447130C CN100447130C (zh) | 2008-12-31 |
Family
ID=34575667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004800399139A Active CN100447130C (zh) | 2003-11-06 | 2004-11-05 | 酰氨基乙腈衍生物 |
Country Status (22)
Country | Link |
---|---|
US (2) | US7494956B2 (zh) |
EP (1) | EP1682493B8 (zh) |
JP (1) | JP4319680B2 (zh) |
KR (1) | KR100793462B1 (zh) |
CN (1) | CN100447130C (zh) |
AR (1) | AR046322A1 (zh) |
AT (1) | ATE420066T1 (zh) |
AU (1) | AU2004287611B2 (zh) |
BR (1) | BRPI0416294B1 (zh) |
CA (1) | CA2544741C (zh) |
DE (1) | DE602004018967D1 (zh) |
DK (1) | DK1682493T3 (zh) |
ES (1) | ES2317070T3 (zh) |
GB (1) | GB0402677D0 (zh) |
MX (1) | MXPA06005036A (zh) |
NZ (1) | NZ546830A (zh) |
PL (1) | PL1682493T3 (zh) |
PT (1) | PT1682493E (zh) |
RU (1) | RU2370485C2 (zh) |
SI (1) | SI1682493T1 (zh) |
TW (1) | TWI342875B (zh) |
WO (1) | WO2005044784A1 (zh) |
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CN104364232A (zh) * | 2012-03-23 | 2015-02-18 | 皮特尼制药股份有限公司 | 用于癌症治疗的激酶抑制剂 |
CN105492452A (zh) * | 2013-07-01 | 2016-04-13 | 苏黎世大学 | 有机金属2-氰基-2-氨基苯甲酸基丙基衍生物及其作为抗蠕虫药的用途 |
CN105658056A (zh) * | 2013-07-01 | 2016-06-08 | 苏黎世大学 | 用作杀线虫药物的n-(1-氰基-2-羟基-1-甲基-乙基)-4-(三氟甲基巯基)苯甲酰胺衍生物 |
CN105683206A (zh) * | 2013-09-26 | 2016-06-15 | 苏黎世大学 | 二有机金属2-氨基-3-羟基-2-甲基丙腈衍生物作为抗蠕虫药的用途 |
CN105682464A (zh) * | 2013-09-26 | 2016-06-15 | 苏黎世大学 | 用作抗蠕虫药的有机金属n-2-氰基-1-羟丙-2基 |
CN105792823A (zh) * | 2013-11-01 | 2016-07-20 | 皮特尼制药股份有限公司 | 治疗恶性肿瘤的药物组合 |
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GB0402677D0 (en) * | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
SI1731512T1 (sl) | 2004-03-05 | 2015-01-30 | Nissan Chemical Industries, Ltd. | Z izoksazolinom substituirana benzamidna spojina in sredstvo za uravnavanje škodljivih organizmov |
CN101056849B (zh) * | 2004-11-09 | 2012-10-17 | 诺瓦提斯公司 | 从其外消旋体制备酰氨基乙腈化合物的对映体的方法 |
RU2425825C2 (ru) * | 2007-02-09 | 2011-08-10 | Пфайзер Лимитед | Амидоацетонитрильные производные, содержащие их фармацевтические композиции и их применение в изготовлении лекарственного средства |
WO2008102232A1 (en) * | 2007-02-21 | 2008-08-28 | Pfizer Limited | Benzofuran antiparasitic agents |
DK2639228T3 (en) | 2007-05-15 | 2016-09-12 | Merial Inc | Aryloazol-2-yl-cyanoethylaminoforbindelser, method of making and method of use thereof |
DK2883545T3 (en) | 2007-06-07 | 2018-11-05 | Bayer Animal Health Gmbh | Control of ectoparasites |
BRPI0810929B8 (pt) | 2007-06-27 | 2022-12-06 | Du Pont | uso de um composto de fórmula 1 |
TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
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GB0905365D0 (en) | 2009-03-27 | 2009-05-13 | Norbrook Lab Ltd | A topical parasiticide composition |
US8859003B2 (en) * | 2009-06-05 | 2014-10-14 | Intercontinental Great Brands Llc | Preparation of an enteric release system |
US20100310726A1 (en) | 2009-06-05 | 2010-12-09 | Kraft Foods Global Brands Llc | Novel Preparation of an Enteric Release System |
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US8822689B2 (en) | 2012-09-19 | 2014-09-02 | Merial Limited | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
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CN103030575B (zh) * | 2013-01-04 | 2014-10-01 | 中国农业大学 | 一类双氰基酰胺化合物及其合成方法与应用 |
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US9907778B2 (en) | 2013-09-13 | 2018-03-06 | Pitney Pharmaceuticals Pty Limited | Anticancer agent comprising aminoacetonitrile compound as active ingredient |
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TW200400932A (en) | 2002-06-19 | 2004-01-16 | Novartis Ag | Organic compounds |
AR042420A1 (es) | 2002-09-11 | 2005-06-22 | Novartis Ag | Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica |
GB0402677D0 (en) * | 2003-11-06 | 2004-03-10 | Novartis Ag | Organic compounds |
AR046757A1 (es) | 2003-12-10 | 2005-12-21 | Novartis Ag | Amidoacetonitrilos utiles como pesticidas |
TW200613251A (en) | 2004-06-10 | 2006-05-01 | Novartis Ag | Organic compounds |
CN101056849B (zh) | 2004-11-09 | 2012-10-17 | 诺瓦提斯公司 | 从其外消旋体制备酰氨基乙腈化合物的对映体的方法 |
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CN105792823A (zh) * | 2013-11-01 | 2016-07-20 | 皮特尼制药股份有限公司 | 治疗恶性肿瘤的药物组合 |
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