CN1890372A - 通过发酵制备精细化学品的方法 - Google Patents

通过发酵制备精细化学品的方法 Download PDF

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Publication number
CN1890372A
CN1890372A CNA2004800363724A CN200480036372A CN1890372A CN 1890372 A CN1890372 A CN 1890372A CN A2004800363724 A CNA2004800363724 A CN A2004800363724A CN 200480036372 A CN200480036372 A CN 200480036372A CN 1890372 A CN1890372 A CN 1890372A
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China
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gene
fructose
microorganism
protein
glucose
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CNA2004800363724A
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English (en)
Chinese (zh)
Inventor
O·策尔德尔
C·克洛普罗格
H·施罗德
S·哈夫纳
B·克勒格尔
P·基弗
E·海因茨勒
C·维特曼
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BASF SE
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BASF SE
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Publication of CN1890372A publication Critical patent/CN1890372A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CNA2004800363724A 2003-12-18 2004-12-17 通过发酵制备精细化学品的方法 Pending CN1890372A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB0306456 2003-12-18
WOPCT/IB2003/006456 2003-12-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2007103011883A Division CN101230355A (zh) 2003-12-18 2004-12-17 通过发酵制备精细化学品的方法

Publications (1)

Publication Number Publication Date
CN1890372A true CN1890372A (zh) 2007-01-03

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ID=34685565

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2004800363724A Pending CN1890372A (zh) 2003-12-18 2004-12-17 通过发酵制备精细化学品的方法
CNA2007103011883A Pending CN101230355A (zh) 2003-12-18 2004-12-17 通过发酵制备精细化学品的方法

Family Applications After (1)

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CNA2007103011883A Pending CN101230355A (zh) 2003-12-18 2004-12-17 通过发酵制备精细化学品的方法

Country Status (15)

Country Link
US (3) US20080032374A1 (enExample)
EP (2) EP1939296A3 (enExample)
JP (2) JP2007514437A (enExample)
KR (1) KR20060125804A (enExample)
CN (2) CN1890372A (enExample)
AR (1) AR047153A1 (enExample)
AU (1) AU2004299729A1 (enExample)
BR (1) BRPI0417772A (enExample)
CA (1) CA2547860A1 (enExample)
IN (2) IN2006CH02603A (enExample)
MX (1) MXPA06006759A (enExample)
NO (1) NO20062494L (enExample)
RU (1) RU2006125500A (enExample)
TW (1) TW200533745A (enExample)
WO (1) WO2005059139A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753692A (zh) * 2010-06-15 2012-10-24 白光产业株式会社 使用微生物生产天冬氨酸族氨基酸的方法
CN103003426A (zh) * 2010-05-03 2013-03-27 于利奇研究中心有限公司 用于胞内代谢物检测的传感器
WO2018040469A1 (zh) 2016-09-01 2018-03-08 宁夏伊品生物科技股份有限公司 发酵生产l-赖氨酸的棒杆菌
CN113430119A (zh) * 2008-03-27 2021-09-24 基因组股份公司 用于产生己二酸和其他化合物的微生物
CN113736761A (zh) * 2021-08-18 2021-12-03 新发药业有限公司 Rna解旋酶突变体、突变基因及其在制备维生素b2中的应用

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DE10359594A1 (de) * 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
EP1584680A1 (en) * 2004-04-08 2005-10-12 Boehringer Ingelheim Austria GmbH Fed-batch fermentation process for the production of plasmid DNA
DE102005056669A1 (de) * 2005-11-28 2007-05-31 Basf Ag Fermentative Herstellung organischer Verbindungen unter Einsatz Dextrin-haltiger Medien
EP1996714A1 (en) * 2006-03-09 2008-12-03 Basf Se PROCESS FOR THE PRODUCTION OF ß-LYSINE
KR101476487B1 (ko) * 2007-10-05 2014-12-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 플라즈마-증착된 미공성 층을 포함하는 유기 화학적 센서와, 제조 및 사용 방법
KR100964078B1 (ko) 2008-03-05 2010-06-16 씨제이제일제당 (주) 5'-이노신산 생산능이 향상된 코리네박테리움암모니아게네스 및 그를 이용한 5'-이노신산 생산 방법
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
BRPI1013426A2 (pt) 2009-04-30 2016-11-08 Genomatica Inc organismos para produção de 1,3-butanodiol
CN109136161A (zh) * 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
WO2011073278A1 (en) 2009-12-17 2011-06-23 Basf Se Processes and recombinant microorganisms for the production of cadaverine
US9309543B2 (en) * 2010-03-18 2016-04-12 William Marsh Rice University Bacteria and method for synthesizing fatty acids
RU2486248C2 (ru) * 2011-06-29 2013-06-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет инженерной экологии" (ФГБОУ ВПО "МГУИЭ") Способ биосинтеза l-лизина
WO2013059218A1 (en) 2011-10-17 2013-04-25 William Marsh Rice University Bacteria and method for synthesizing fatty acids
EP2971023B1 (en) * 2013-03-15 2024-12-11 Kiverdi, Inc. Methods of using natural and engineered organisms to produce small molecules for industrial application
CN104845923B (zh) 2014-02-14 2018-03-23 中国科学院微生物研究所 生产l‑组氨酸的方法及其专用重组菌
KR101621243B1 (ko) 2014-08-28 2016-05-16 씨제이제일제당 주식회사 L-라이신 생산능을 갖는 코리네박테리움 미생물 및 이를 이용한 l-라이신 생산 방법
WO2016090164A1 (en) * 2014-12-03 2016-06-09 Fenner U.S., Inc. Improved filament for fused deposit modeling
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN106190939B (zh) * 2016-07-18 2020-04-07 清华大学 高产透明质酸的重组谷氨酸棒杆菌及其制备方法与应用
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN109536431A (zh) * 2018-12-04 2019-03-29 江苏省农业科学院 复合生化复苏因子组合物及其应用
KR102147776B1 (ko) 2019-09-20 2020-08-26 대상 주식회사 L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법
CN111471693B (zh) * 2019-11-27 2022-04-01 内蒙古伊品生物科技有限公司 一种产赖氨酸的谷氨酸棒杆菌及其构建方法与应用
CN113136382B (zh) * 2020-01-19 2023-01-31 河北科技大学 基于CRISPRi调控的利用谷氨酸棒状杆菌合成乙醛酸的方法
EP4332230A4 (en) * 2021-04-30 2025-06-25 CJ Cheiljedang Corporation CORYNEBACTERIUM GLUTAMICUM VARIANT WITH IMPROVED L-LYSINE PRODUCTION CAPACITY AND METHOD FOR PRODUCING L-LYSINE THEREOF
CN115490761B (zh) * 2021-11-01 2023-06-09 中国科学院天津工业生物技术研究所 基于赖氨酸外排蛋白构建的重组微生物及生产赖氨酸的方法
CN116179586A (zh) * 2021-11-26 2023-05-30 上海凯赛生物技术股份有限公司 用于发酵生产l-赖氨酸的表达盒、菌株及其应用
CN116411009A (zh) * 2021-12-31 2023-07-11 上海凯赛生物技术股份有限公司 用于制备l-赖氨酸的表达盒、基因工程菌及其应用
CN115948313A (zh) * 2022-11-10 2023-04-11 清华大学 提高赖氨酸和戊二胺发酵产量的方法

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DE69529026T2 (de) 1994-07-19 2003-07-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama Trehalose, ihre Herstellung und ihre Verwendung
KR20070087088A (ko) 1999-06-25 2007-08-27 바스프 악티엔게젤샤프트 탄소 대사 및 에너지 생산과 관련된 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자
CA2383865A1 (en) 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding metabolic pathway proteins
DK1208205T3 (da) 1999-07-23 2007-02-05 Archer Daniels Midland Co Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH
US6586214B1 (en) * 1999-09-15 2003-07-01 Degussa Ag Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
DE19956686A1 (de) 1999-11-25 2001-05-31 Degussa Neue für die Gene sucC und sucD codierende Nukleotidsequenzen
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
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US7049106B2 (en) * 2001-04-10 2006-05-23 Degussa Ag Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113430119A (zh) * 2008-03-27 2021-09-24 基因组股份公司 用于产生己二酸和其他化合物的微生物
CN103003426A (zh) * 2010-05-03 2013-03-27 于利奇研究中心有限公司 用于胞内代谢物检测的传感器
CN102753692A (zh) * 2010-06-15 2012-10-24 白光产业株式会社 使用微生物生产天冬氨酸族氨基酸的方法
WO2018040469A1 (zh) 2016-09-01 2018-03-08 宁夏伊品生物科技股份有限公司 发酵生产l-赖氨酸的棒杆菌
US11242545B2 (en) 2016-09-01 2022-02-08 Ningxia Eppen Biotech Co., Ltd Corynebacterium for producing L-lysine by fermentation
CN113736761A (zh) * 2021-08-18 2021-12-03 新发药业有限公司 Rna解旋酶突变体、突变基因及其在制备维生素b2中的应用

Also Published As

Publication number Publication date
BRPI0417772A (pt) 2007-04-17
WO2005059139A3 (en) 2005-08-11
MXPA06006759A (es) 2006-09-04
JP2007514437A (ja) 2007-06-07
JP4903742B2 (ja) 2012-03-28
US8048651B2 (en) 2011-11-01
IN2006CH02603A (enExample) 2007-06-08
EP1939296A2 (en) 2008-07-02
AU2004299729A1 (en) 2005-06-30
EP1939296A3 (en) 2010-08-25
CA2547860A1 (en) 2005-06-30
IN2008CH00387A (enExample) 2008-09-19
AR047153A1 (es) 2006-01-11
CN101230355A (zh) 2008-07-30
RU2006125500A (ru) 2008-01-27
TW200533745A (en) 2005-10-16
WO2005059139A2 (en) 2005-06-30
JP2008259505A (ja) 2008-10-30
US20080160585A1 (en) 2008-07-03
US20100015674A1 (en) 2010-01-21
NO20062494L (no) 2006-09-06
EP1697518A2 (en) 2006-09-06
US20080032374A1 (en) 2008-02-07
KR20060125804A (ko) 2006-12-06

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