AR047153A1 - Metodos para la preparacion de un quimico fino por fermentacion - Google Patents
Metodos para la preparacion de un quimico fino por fermentacionInfo
- Publication number
- AR047153A1 AR047153A1 ARP040104741A ARP040104741A AR047153A1 AR 047153 A1 AR047153 A1 AR 047153A1 AR P040104741 A ARP040104741 A AR P040104741A AR P040104741 A ARP040104741 A AR P040104741A AR 047153 A1 AR047153 A1 AR 047153A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- increasing
- lysine
- production
- fructose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Abstract
Métodos para aumentar la produccion de un compuesto químico fino, por ejemplo, lisina a partir de un microorganismo, por ejemplo, Corynebacterium mediante la desregulacion de un gen codificador de una enzima, es decir, fructosa-1,6-bisfosfatasa. En una forma de realizacion de preferencia, se proveen métodos para incrementar la produccion de lisina en Corynebacterium glutamicun a través del incremento de la expresion de la actividad de fructosa-1,6-bisfosfatasa. También se provee un proceso nuevo para la produccion de lisina a través de la regulacion de flujo de carbono hacia oxalacetato (OAA). En una forma de realizacion de preferencia, se proveen métodos para la produccion de lisina a través de la utilizacion de fructosa o sacarosa como fuente de carbono. Reivindicacion 1: Un método para aumentar el flujo metabolico a través de la vía de pentosafosfatos en un microorganismo que comprenda el cultivo de dicho microorganismo que contenga un gen que se desregula bajo condiciones tales que se aumenta el flujo metabolico a través de la vía de pentosafosfatos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB0306456 | 2003-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047153A1 true AR047153A1 (es) | 2006-01-11 |
Family
ID=34685565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104741A AR047153A1 (es) | 2003-12-18 | 2004-12-17 | Metodos para la preparacion de un quimico fino por fermentacion |
Country Status (15)
Country | Link |
---|---|
US (3) | US20080032374A1 (es) |
EP (2) | EP1939296A3 (es) |
JP (2) | JP2007514437A (es) |
KR (1) | KR20060125804A (es) |
CN (2) | CN1890372A (es) |
AR (1) | AR047153A1 (es) |
AU (1) | AU2004299729A1 (es) |
BR (1) | BRPI0417772A (es) |
CA (1) | CA2547860A1 (es) |
IN (2) | IN2006CH02603A (es) |
MX (1) | MXPA06006759A (es) |
NO (1) | NO20062494L (es) |
RU (1) | RU2006125500A (es) |
TW (1) | TW200533745A (es) |
WO (1) | WO2005059139A2 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10359594A1 (de) * | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
EP1584680A1 (en) * | 2004-04-08 | 2005-10-12 | Boehringer Ingelheim Austria GmbH | Fed-batch fermentation process for the production of plasmid DNA |
DE102005056669A1 (de) * | 2005-11-28 | 2007-05-31 | Basf Ag | Fermentative Herstellung organischer Verbindungen unter Einsatz Dextrin-haltiger Medien |
US20090029425A1 (en) * | 2006-03-09 | 2009-01-29 | Basf Se | Process for the production of beta-lysine |
EP2208058B1 (en) * | 2007-10-05 | 2018-07-11 | 3M Innovative Properties Company | Organic chemical sensor comprising plasma-deposited microporous layer, and method of making and using |
KR100964078B1 (ko) | 2008-03-05 | 2010-06-16 | 씨제이제일제당 (주) | 5'-이노신산 생산능이 향상된 코리네박테리움암모니아게네스 및 그를 이용한 5'-이노신산 생산 방법 |
HUE035611T2 (en) * | 2008-03-27 | 2018-05-28 | Genomatica Inc | Microorganisms suitable for the production of adipic acid and other compounds |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
EP4321615A3 (en) | 2009-04-30 | 2024-02-21 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
WO2011071682A1 (en) * | 2009-12-10 | 2011-06-16 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
DE112010004851T5 (de) | 2009-12-17 | 2012-09-20 | Basf Se | Verfahren und rekombinante Mikroorganismen für die Herstellung von Cadaverin |
WO2011116279A2 (en) * | 2010-03-18 | 2011-09-22 | William Marsh Rice University | Bacteria and method for synthesizing fatty acids |
DE102010019059A1 (de) | 2010-05-03 | 2011-11-03 | Forschungszentrum Jülich GmbH | Sensoren zur intrazellulären Metabolit-Detektion |
JP5719434B2 (ja) | 2010-06-15 | 2015-05-20 | パク グアン インダストリアル カンパニー リミテッドPaik Kwang Industrial Co., Ltd. | 微生物を用いたアスパラギン酸系アミノ酸の生産方法 |
RU2486248C2 (ru) * | 2011-06-29 | 2013-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет инженерной экологии" (ФГБОУ ВПО "МГУИЭ") | Способ биосинтеза l-лизина |
US9598696B2 (en) | 2011-10-17 | 2017-03-21 | William Marsh Rice University | Bacteria and method for synthesizing fatty acids |
EP2971023A4 (en) * | 2013-03-15 | 2017-03-15 | Kiverdi, Inc. | Methods of using natural and engineered organisms to produce small molecules for industrial application |
CN104845923B (zh) * | 2014-02-14 | 2018-03-23 | 中国科学院微生物研究所 | 生产l‑组氨酸的方法及其专用重组菌 |
KR101621243B1 (ko) * | 2014-08-28 | 2016-05-16 | 씨제이제일제당 주식회사 | L-라이신 생산능을 갖는 코리네박테리움 미생물 및 이를 이용한 l-라이신 생산 방법 |
WO2016090164A1 (en) * | 2014-12-03 | 2016-06-09 | Fenner U.S., Inc. | Improved filament for fused deposit modeling |
CN111040980B (zh) * | 2016-07-18 | 2021-09-03 | 清华大学 | 高产低分子量透明质酸的重组谷氨酸棒杆菌及其构建方法与应用 |
US11242545B2 (en) | 2016-09-01 | 2022-02-08 | Ningxia Eppen Biotech Co., Ltd | Corynebacterium for producing L-lysine by fermentation |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
CN109536431A (zh) * | 2018-12-04 | 2019-03-29 | 江苏省农业科学院 | 复合生化复苏因子组合物及其应用 |
KR102147776B1 (ko) | 2019-09-20 | 2020-08-26 | 대상 주식회사 | L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법 |
CN111471693B (zh) * | 2019-11-27 | 2022-04-01 | 内蒙古伊品生物科技有限公司 | 一种产赖氨酸的谷氨酸棒杆菌及其构建方法与应用 |
CN113136382B (zh) * | 2020-01-19 | 2023-01-31 | 河北科技大学 | 基于CRISPRi调控的利用谷氨酸棒状杆菌合成乙醛酸的方法 |
CA3217305A1 (en) * | 2021-04-30 | 2022-11-03 | In Pyo Hong | Corynebacterium glutamicum variant with improved l-lysine production ability, and method for producing l-lysine using same |
CN113736761B (zh) * | 2021-08-18 | 2023-06-27 | 新发药业有限公司 | Rna解旋酶突变体、突变基因及其在制备维生素b2中的应用 |
CN115490761B (zh) * | 2021-11-01 | 2023-06-09 | 中国科学院天津工业生物技术研究所 | 基于赖氨酸外排蛋白构建的重组微生物及生产赖氨酸的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69529026T2 (de) | 1994-07-19 | 2003-07-17 | Hayashibara Biochem Lab | Trehalose, ihre Herstellung und ihre Verwendung |
KR100878334B1 (ko) | 1999-06-25 | 2009-01-14 | 백광산업 주식회사 | 대사 경로 단백질을 코딩하는 코리네박테리움 글루타미쿰유전자 |
EP1263963A2 (en) * | 1999-06-25 | 2002-12-11 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production |
BR0012712B1 (pt) | 1999-07-23 | 2011-12-13 | métodos de produção de l-aminoácidos aumentando-se o nadph celular. | |
US6586214B1 (en) * | 1999-09-15 | 2003-07-01 | Degussa Ag | Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene) |
DE19956686A1 (de) | 1999-11-25 | 2001-05-31 | Degussa | Neue für die Gene sucC und sucD codierende Nukleotidsequenzen |
JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
DE10046870A1 (de) | 2000-09-20 | 2002-03-28 | Basf Ag | Verfahren zur Veränderung des Genoms von Corynebakterien |
US7049106B2 (en) * | 2001-04-10 | 2006-05-23 | Degussa Ag | Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene |
US20090158452A1 (en) * | 2001-12-04 | 2009-06-18 | Johnson Richard G | Transgenic plants with enhanced agronomic traits |
DE10394220T5 (de) | 2003-04-04 | 2006-03-16 | Soken Chemical & Engineering Co. Ltd. | Modifizierte Cycloolefin-Copolymere, Verfahren zu deren Herstellung und Verwendungen dieser Polymere |
-
2004
- 2004-12-17 RU RU2006125500/13A patent/RU2006125500A/ru not_active Application Discontinuation
- 2004-12-17 KR KR1020067011961A patent/KR20060125804A/ko not_active Application Discontinuation
- 2004-12-17 JP JP2006544604A patent/JP2007514437A/ja not_active Withdrawn
- 2004-12-17 EP EP07123936A patent/EP1939296A3/en not_active Withdrawn
- 2004-12-17 CN CNA2004800363724A patent/CN1890372A/zh active Pending
- 2004-12-17 CN CNA2007103011883A patent/CN101230355A/zh active Pending
- 2004-12-17 IN IN2603CH2006 patent/IN2006CH02603A/en unknown
- 2004-12-17 MX MXPA06006759A patent/MXPA06006759A/es not_active Application Discontinuation
- 2004-12-17 WO PCT/IB2004/004429 patent/WO2005059139A2/en active Application Filing
- 2004-12-17 EP EP04817630A patent/EP1697518A2/en not_active Withdrawn
- 2004-12-17 TW TW93139526A patent/TW200533745A/zh unknown
- 2004-12-17 AR ARP040104741A patent/AR047153A1/es not_active Application Discontinuation
- 2004-12-17 BR BRPI0417772-0A patent/BRPI0417772A/pt not_active Application Discontinuation
- 2004-12-17 US US10/579,690 patent/US20080032374A1/en not_active Abandoned
- 2004-12-17 CA CA002547860A patent/CA2547860A1/en not_active Abandoned
- 2004-12-17 AU AU2004299729A patent/AU2004299729A1/en not_active Abandoned
-
2006
- 2006-05-31 NO NO20062494A patent/NO20062494L/no not_active Application Discontinuation
-
2008
- 2008-01-23 IN IN387CH2008 patent/IN2008CH00387A/en unknown
- 2008-01-28 US US12/021,081 patent/US20080160585A1/en not_active Abandoned
- 2008-04-02 JP JP2008095922A patent/JP4903742B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-31 US US12/533,677 patent/US8048651B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2547860A1 (en) | 2005-06-30 |
IN2006CH02603A (es) | 2007-06-08 |
CN1890372A (zh) | 2007-01-03 |
US20080160585A1 (en) | 2008-07-03 |
JP2008259505A (ja) | 2008-10-30 |
JP2007514437A (ja) | 2007-06-07 |
TW200533745A (en) | 2005-10-16 |
NO20062494L (no) | 2006-09-06 |
RU2006125500A (ru) | 2008-01-27 |
BRPI0417772A (pt) | 2007-04-17 |
CN101230355A (zh) | 2008-07-30 |
WO2005059139A2 (en) | 2005-06-30 |
MXPA06006759A (es) | 2006-09-04 |
US20100015674A1 (en) | 2010-01-21 |
US20080032374A1 (en) | 2008-02-07 |
KR20060125804A (ko) | 2006-12-06 |
AU2004299729A1 (en) | 2005-06-30 |
US8048651B2 (en) | 2011-11-01 |
EP1939296A3 (en) | 2010-08-25 |
EP1939296A2 (en) | 2008-07-02 |
IN2008CH00387A (es) | 2008-09-19 |
JP4903742B2 (ja) | 2012-03-28 |
EP1697518A2 (en) | 2006-09-06 |
WO2005059139A3 (en) | 2005-08-11 |
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Legal Events
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