AR047153A1 - Metodos para la preparacion de un quimico fino por fermentacion - Google Patents

Metodos para la preparacion de un quimico fino por fermentacion

Info

Publication number
AR047153A1
AR047153A1 ARP040104741A ARP040104741A AR047153A1 AR 047153 A1 AR047153 A1 AR 047153A1 AR P040104741 A ARP040104741 A AR P040104741A AR P040104741 A ARP040104741 A AR P040104741A AR 047153 A1 AR047153 A1 AR 047153A1
Authority
AR
Argentina
Prior art keywords
methods
increasing
lysine
production
fructose
Prior art date
Application number
ARP040104741A
Other languages
English (en)
Inventor
Oskar Zelder
Corinna Klopprogge
Hartwig Schroeder
Patrick Kiefer
Stefan Haefner
Burkhard Kroeger
Elmar Heinzle
Christoph Wittmann
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of AR047153A1 publication Critical patent/AR047153A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Métodos para aumentar la produccion de un compuesto químico fino, por ejemplo, lisina a partir de un microorganismo, por ejemplo, Corynebacterium mediante la desregulacion de un gen codificador de una enzima, es decir, fructosa-1,6-bisfosfatasa. En una forma de realizacion de preferencia, se proveen métodos para incrementar la produccion de lisina en Corynebacterium glutamicun a través del incremento de la expresion de la actividad de fructosa-1,6-bisfosfatasa. También se provee un proceso nuevo para la produccion de lisina a través de la regulacion de flujo de carbono hacia oxalacetato (OAA). En una forma de realizacion de preferencia, se proveen métodos para la produccion de lisina a través de la utilizacion de fructosa o sacarosa como fuente de carbono. Reivindicacion 1: Un método para aumentar el flujo metabolico a través de la vía de pentosafosfatos en un microorganismo que comprenda el cultivo de dicho microorganismo que contenga un gen que se desregula bajo condiciones tales que se aumenta el flujo metabolico a través de la vía de pentosafosfatos.
ARP040104741A 2003-12-18 2004-12-17 Metodos para la preparacion de un quimico fino por fermentacion AR047153A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB0306456 2003-12-18

Publications (1)

Publication Number Publication Date
AR047153A1 true AR047153A1 (es) 2006-01-11

Family

ID=34685565

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104741A AR047153A1 (es) 2003-12-18 2004-12-17 Metodos para la preparacion de un quimico fino por fermentacion

Country Status (15)

Country Link
US (3) US20080032374A1 (es)
EP (2) EP1697518A2 (es)
JP (2) JP2007514437A (es)
KR (1) KR20060125804A (es)
CN (2) CN1890372A (es)
AR (1) AR047153A1 (es)
AU (1) AU2004299729A1 (es)
BR (1) BRPI0417772A (es)
CA (1) CA2547860A1 (es)
IN (2) IN2006CH02603A (es)
MX (1) MXPA06006759A (es)
NO (1) NO20062494L (es)
RU (1) RU2006125500A (es)
TW (1) TW200533745A (es)
WO (1) WO2005059139A2 (es)

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DE102005056669A1 (de) * 2005-11-28 2007-05-31 Basf Ag Fermentative Herstellung organischer Verbindungen unter Einsatz Dextrin-haltiger Medien
BRPI0708680A2 (pt) * 2006-03-09 2011-06-07 Basf Se processo para produção de beta-lisina, para a produção de beta-amino-epsilon-caprolactama, para a produção de epsilon-caprolactama, e para a produção de ácido epsilon-amino-capróico
US8378694B2 (en) * 2007-10-05 2013-02-19 3M Innovative Properties Company Organic chemical sensor comprising plasma-deposited microporous layer, and method of making and using
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CN102066551B (zh) * 2008-03-27 2013-10-09 基因组股份公司 用于产生己二酸和其他化合物的微生物
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
EP3318626B1 (en) 2009-04-30 2020-01-15 Genomatica, Inc. Organisms for the production of 1,3-butanediol
EP2510102A4 (en) * 2009-12-10 2014-01-22 Genomatica Inc METHODS AND ORGANIZATIONS FOR THE CONVERSION OF SYNTHESIS GAS OR OTHER CARBONACEOUS GAS SOURCES AND METHANOL TO 1,3-BUTANEDIOL
JP5960604B2 (ja) 2009-12-17 2016-08-02 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ カダベリンの生産のための方法及び組換え微生物
WO2011116279A2 (en) * 2010-03-18 2011-09-22 William Marsh Rice University Bacteria and method for synthesizing fatty acids
DE102010019059A1 (de) 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
US9169502B2 (en) * 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
RU2486248C2 (ru) * 2011-06-29 2013-06-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет инженерной экологии" (ФГБОУ ВПО "МГУИЭ") Способ биосинтеза l-лизина
EP2768966B1 (en) 2011-10-17 2019-04-17 William Marsh Rice University Bacteria and method for synthesizing fatty acids
WO2014145194A2 (en) * 2013-03-15 2014-09-18 Kiverdi, Inc. Methods of using natural and engineered organisms to produce small molecules for industrial application
CN104845923B (zh) 2014-02-14 2018-03-23 中国科学院微生物研究所 生产l‑组氨酸的方法及其专用重组菌
KR101621243B1 (ko) * 2014-08-28 2016-05-16 씨제이제일제당 주식회사 L-라이신 생산능을 갖는 코리네박테리움 미생물 및 이를 이용한 l-라이신 생산 방법
WO2016090164A1 (en) * 2014-12-03 2016-06-09 Fenner U.S., Inc. Improved filament for fused deposit modeling
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN106190939B (zh) * 2016-07-18 2020-04-07 清华大学 高产透明质酸的重组谷氨酸棒杆菌及其制备方法与应用
PL3533875T3 (pl) 2016-09-01 2023-06-12 Ningxia Eppen Biotech Co. Ltd Corynebacterium do wytwarzania L-lizyny przez fermentację
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN109536431A (zh) * 2018-12-04 2019-03-29 江苏省农业科学院 复合生化复苏因子组合物及其应用
KR102147776B1 (ko) 2019-09-20 2020-08-26 대상 주식회사 L-라이신 생산능력이 향상된 코리네박테리움속 미생물 및 이를 이용한 라이신의 생산 방법
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CN111471693B (zh) * 2019-11-27 2022-04-01 内蒙古伊品生物科技有限公司 一种产赖氨酸的谷氨酸棒杆菌及其构建方法与应用
CN113136382B (zh) * 2020-01-19 2023-01-31 河北科技大学 基于CRISPRi调控的利用谷氨酸棒状杆菌合成乙醛酸的方法
KR20230092008A (ko) * 2020-10-28 2023-06-23 아지노모토 가부시키가이샤 L-아미노산의 제조법
BR112023022512A2 (pt) * 2021-04-30 2024-01-02 Cj Cheiljedang Corp Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina
CN113736761B (zh) * 2021-08-18 2023-06-27 新发药业有限公司 Rna解旋酶突变体、突变基因及其在制备维生素b2中的应用
CN115490761B (zh) * 2021-11-01 2023-06-09 中国科学院天津工业生物技术研究所 基于赖氨酸外排蛋白构建的重组微生物及生产赖氨酸的方法
CN116179586A (zh) * 2021-11-26 2023-05-30 上海凯赛生物技术股份有限公司 用于发酵生产l-赖氨酸的表达盒、菌株及其应用
CN116411009A (zh) * 2021-12-31 2023-07-11 上海凯赛生物技术股份有限公司 用于制备l-赖氨酸的表达盒、基因工程菌及其应用
CN115948313A (zh) * 2022-11-10 2023-04-11 清华大学 提高赖氨酸和戊二胺发酵产量的方法

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Also Published As

Publication number Publication date
EP1697518A2 (en) 2006-09-06
EP1939296A3 (en) 2010-08-25
JP4903742B2 (ja) 2012-03-28
MXPA06006759A (es) 2006-09-04
CN1890372A (zh) 2007-01-03
JP2007514437A (ja) 2007-06-07
US8048651B2 (en) 2011-11-01
EP1939296A2 (en) 2008-07-02
US20080032374A1 (en) 2008-02-07
IN2008CH00387A (es) 2008-09-19
TW200533745A (en) 2005-10-16
CA2547860A1 (en) 2005-06-30
BRPI0417772A (pt) 2007-04-17
AU2004299729A1 (en) 2005-06-30
CN101230355A (zh) 2008-07-30
IN2006CH02603A (es) 2007-06-08
US20080160585A1 (en) 2008-07-03
JP2008259505A (ja) 2008-10-30
WO2005059139A2 (en) 2005-06-30
US20100015674A1 (en) 2010-01-21
NO20062494L (no) 2006-09-06
RU2006125500A (ru) 2008-01-27
WO2005059139A3 (en) 2005-08-11
KR20060125804A (ko) 2006-12-06

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