BR112023022512A2 - Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina - Google Patents

Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina

Info

Publication number
BR112023022512A2
BR112023022512A2 BR112023022512A BR112023022512A BR112023022512A2 BR 112023022512 A2 BR112023022512 A2 BR 112023022512A2 BR 112023022512 A BR112023022512 A BR 112023022512A BR 112023022512 A BR112023022512 A BR 112023022512A BR 112023022512 A2 BR112023022512 A2 BR 112023022512A2
Authority
BR
Brazil
Prior art keywords
corynebacterium glutamicum
lysine production
variant
promoter
lysine
Prior art date
Application number
BR112023022512A
Other languages
English (en)
Inventor
Eun Kim Ha
Pyo Hong In
Hyun Park Joon
Hyun Park Seok
Hee Lee Sun
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020210067391A external-priority patent/KR20220149379A/ko
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of BR112023022512A2 publication Critical patent/BR112023022512A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/265—Micrococcus
    • C12R2001/28—Micrococcus glutamicus ; Corynebacterium glutamicum

Abstract

promotor, variante de corynebacterium glutamicum e método para produção de l-lisina. a presente invenção é relacionada com uma variante de corynebacterium glutamicum que tem capacidade de produção de l-lisina aprimorada e um método para produção de l-lisina usando a mesma. a variante pode melhorar o rendimento de produção de l-lisina se comparado a uma cepa parental aumentando-se ou intensificando-se a expressão de um gene que codifica transcetolase.
BR112023022512A 2021-04-30 2021-05-28 Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina BR112023022512A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20210056580 2021-04-30
KR1020210067391A KR20220149379A (ko) 2021-04-30 2021-05-26 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
PCT/KR2021/006681 WO2022231056A1 (ko) 2021-04-30 2021-05-28 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법

Publications (1)

Publication Number Publication Date
BR112023022512A2 true BR112023022512A2 (pt) 2024-01-02

Family

ID=83758658

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022512A BR112023022512A2 (pt) 2021-04-30 2021-05-28 Promotor, variante de corynebacterium glutamicum e método para produção de l-lisina

Country Status (8)

Country Link
EP (1) EP4332230A1 (pt)
JP (1) JP2024515390A (pt)
KR (1) KR20240000419A (pt)
CN (2) CN115261294B (pt)
AU (1) AU2021443607A1 (pt)
BR (1) BR112023022512A2 (pt)
CA (1) CA3217305A1 (pt)
WO (1) WO2022231056A1 (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0010713A (pt) * 2000-03-17 2002-02-13 Degussa Processo para a preparação fermentativa de l-aminoácidos com amplificação do gene tkt
WO2005059139A2 (en) * 2003-12-18 2005-06-30 Basf Aktiengesellschaft Methods for the preparation of lysine by fermentation of corynebacterium glutamicum
KR100838038B1 (ko) 2006-12-29 2008-06-12 씨제이제일제당 (주) Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법
WO2008101850A1 (en) * 2007-02-19 2008-08-28 Evonik Degussa Gmbh Method of producing methionine in corynebacteria by over-expressing enzymes of the pentose phosphate pathway
EP3404101A3 (en) * 2011-12-21 2018-12-26 Cj Cheiljedang Corporation Method for producing l-lysine using microorganisms having ability to produce l-lysine
KR101504900B1 (ko) * 2013-06-27 2015-03-23 백광산업 주식회사 트랜스케톨라아제 유전자 프로모터 변이체 및 이의 용도
KR101564753B1 (ko) * 2013-12-26 2015-11-13 백광산업 주식회사 코리네형 세균 유래의 치환된 개시코돈을 포함하는 재조합 벡터, 형질전환된 숙주세포 및 이를 이용한 아미노산의 생산방법
US20200239897A1 (en) * 2017-06-07 2020-07-30 Zymergen Inc. Promoters from corynebacterium glutamicum and uses thereof in regulating ancillary gene expression
KR102139806B1 (ko) 2020-02-13 2020-07-30 씨제이제일제당 (주) 변이형 LysE를 포함하는 미생물, 및 이를 이용한 L-아미노산 생산 방법
CN113308426B (zh) * 2021-05-27 2022-10-18 齐鲁工业大学 一种改造tk基因5′端序列的重组棒状杆菌及其应用

Also Published As

Publication number Publication date
CA3217305A1 (en) 2022-11-03
KR20240000419A (ko) 2024-01-02
WO2022231056A1 (ko) 2022-11-03
AU2021443607A1 (en) 2023-11-16
JP2024515390A (ja) 2024-04-09
EP4332230A1 (en) 2024-03-06
CN115261294A (zh) 2022-11-01
CN115261294B (zh) 2024-03-29
CN117511834A (zh) 2024-02-06

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