CN1788008A - 作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑 - Google Patents

作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑 Download PDF

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Publication number
CN1788008A
CN1788008A CNA2004800129905A CN200480012990A CN1788008A CN 1788008 A CN1788008 A CN 1788008A CN A2004800129905 A CNA2004800129905 A CN A2004800129905A CN 200480012990 A CN200480012990 A CN 200480012990A CN 1788008 A CN1788008 A CN 1788008A
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compound
disease
base
halogen
alkyl
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Chinese (zh)
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V·J·科兰德里
G·A·多赫尔蒂
J·J·哈尔
C·林奇
S·G·米尔斯
W·E·纽维三世
L·托思
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Merck and Co Inc
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Merck and Co Inc
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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CNA2004800129905A 2003-05-15 2004-05-12 作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑 Pending CN1788008A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47065903P 2003-05-15 2003-05-15
US60/470,659 2003-05-15

Publications (1)

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CN1788008A true CN1788008A (zh) 2006-06-14

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CNA2004800129905A Pending CN1788008A (zh) 2003-05-15 2004-05-12 作为s1p受体激动剂的3－(2－氨基－1－氮杂环基)－5－芳基－1,2,4－噁二唑

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US (1) US20060252741A1 (enExample)
EP (1) EP1625123A4 (enExample)
JP (1) JP2006528980A (enExample)
CN (1) CN1788008A (enExample)
AU (1) AU2004240586A1 (enExample)
CA (1) CA2524867A1 (enExample)
WO (1) WO2004103279A2 (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100494178C (zh) * 2007-02-02 2009-06-03 广东东阳光药业有限公司 一种吡啶甲脒及其盐的制备方法
CN102361867A (zh) * 2009-01-23 2012-02-22 百时美施贵宝公司 在治疗自身免疫疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物
CN102361868A (zh) * 2009-01-23 2012-02-22 百时美施贵宝公司 作为1-磷酸-鞘氨醇激动剂的吡唑-1，2，4-噁二唑衍生物
CN102471328A (zh) * 2009-07-16 2012-05-23 埃科特莱茵药品有限公司 吡啶-4-基衍生物
CN102648198A (zh) * 2007-08-17 2012-08-22 埃科特莱茵药品有限公司 作为s1p1/edg1受体调节剂的吡啶衍生物
CN101611033B (zh) * 2006-12-21 2012-10-31 葛兰素集团有限公司 作为s1p1受体激动剂的吲哚衍生物
CN101970430B (zh) * 2007-11-01 2013-05-08 埃科特莱茵药品有限公司 嘧啶衍生物
CN101627034B (zh) * 2007-03-16 2013-05-15 埃科特莱茵药品有限公司 氨基-吡啶衍生物作为s1p1/edg1受体激动剂
CN103298807A (zh) * 2010-11-03 2013-09-11 百时美施贵宝公司 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物
CN103313981A (zh) * 2011-01-19 2013-09-18 埃科特莱茵药品有限公司 2-甲氧基-吡啶-4-基衍生物
CN103338770A (zh) * 2010-12-03 2013-10-02 阿勒根公司 作为鞘氨醇1-磷酸(s1p)受体调节剂的新型吡啶衍生物
CN108178759A (zh) * 2018-01-05 2018-06-19 刘玉栋 一种α-肾上腺素受体拮抗剂的合成方法

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AU2005264431B2 (en) * 2004-07-16 2010-08-19 Kyorin Pharmaceutical Co., Ltd. Method of effectively using medicine and method concerning prevention of side effect
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JP4993407B2 (ja) 2004-08-04 2012-08-08 大正製薬株式会社 トリアゾール誘導体
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US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
PT2511262T (pt) * 2004-10-12 2017-03-30 Kyorin Seiyaku Kk Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol
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JP2009527501A (ja) * 2006-02-21 2009-07-30 ユニバーシティ オブ バージニア パテント ファンデーション Ｓ１ｐ受容体アゴニストとしてのフェニル−シクロアルキル誘導体およびフェニル−複素環誘導体
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TWI408139B (zh) 2006-09-07 2013-09-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
MY149853A (en) 2006-09-07 2013-10-31 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
AR062684A1 (es) 2006-09-08 2008-11-26 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3- ilo, composicion farmaceutica que los contiene, y uso de los mismos en la preparacion de medicamentos
JP5250556B2 (ja) 2006-09-21 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド フェニル誘導体及びそれらの免疫調節薬としての使用
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