CN1680374A - 含哌嗪环化合物的新型合成和结晶方法 - Google Patents

含哌嗪环化合物的新型合成和结晶方法 Download PDF

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Publication number
CN1680374A
CN1680374A CNA2005100042895A CN200510004289A CN1680374A CN 1680374 A CN1680374 A CN 1680374A CN A2005100042895 A CNA2005100042895 A CN A2005100042895A CN 200510004289 A CN200510004289 A CN 200510004289A CN 1680374 A CN1680374 A CN 1680374A
Authority
CN
China
Prior art keywords
mirtazapine
phenyl
methyl
piperazine
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005100042895A
Other languages
English (en)
Chinese (zh)
Inventor
克劳德·辛格
安尼塔·利伯曼
尼娜·芬克尔斯坦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CN1680374A publication Critical patent/CN1680374A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2005100042895A 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法 Pending CN1680374A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13004799P 1999-04-19 1999-04-19
US60/130047 1999-04-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN00807574A Division CN1356903A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法

Publications (1)

Publication Number Publication Date
CN1680374A true CN1680374A (zh) 2005-10-12

Family

ID=22442814

Family Applications (4)

Application Number Title Priority Date Filing Date
CNA2005100042895A Pending CN1680374A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法
CNA2005100042880A Pending CN1679586A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法
CN00807574A Pending CN1356903A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法
CNA2005100042908A Pending CN1680365A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CNA2005100042880A Pending CN1679586A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法
CN00807574A Pending CN1356903A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法
CNA2005100042908A Pending CN1680365A (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法

Country Status (16)

Country Link
JP (1) JP2004500324A (enExample)
KR (1) KR20020019902A (enExample)
CN (4) CN1680374A (enExample)
CA (1) CA2368815A1 (enExample)
CZ (1) CZ20013658A3 (enExample)
HK (1) HK1044116A1 (enExample)
HR (1) HRP20010747A2 (enExample)
HU (1) HUP0200839A3 (enExample)
IL (1) IL146023A0 (enExample)
PL (1) PL366289A1 (enExample)
RU (1) RU2001128229A (enExample)
SK (1) SK14672001A3 (enExample)
TR (1) TR200103028T2 (enExample)
WO (1) WO2000062782A1 (enExample)
YU (1) YU74101A (enExample)
ZA (1) ZA200108220B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038329A1 (en) 1999-11-24 2001-05-31 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine crystals and process for producing the same
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
ES2246161B1 (es) * 2004-07-22 2007-04-01 Medichem, S.A. Proceso mejorado para la fabricacion de mirtazapina.
JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
JP5192707B2 (ja) * 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
EP2146993B1 (en) 2007-04-11 2015-08-05 Merck Sharp & Dohme B.V. A method for the preparation of mirtazapine
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
KR101485418B1 (ko) 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
JP2017088564A (ja) * 2015-11-13 2017-05-25 株式会社トクヤマ ミルタザピンの製造方法
JP6571497B2 (ja) * 2015-11-13 2019-09-04 株式会社トクヤマ ミルタザピンの製造方法
CN108191873B (zh) * 2018-01-08 2021-09-24 山东省食品药品检验研究院 一种盐酸米安色林的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Also Published As

Publication number Publication date
JP2004500324A (ja) 2004-01-08
PL366289A1 (en) 2005-01-24
KR20020019902A (ko) 2002-03-13
SK14672001A3 (sk) 2002-11-06
YU74101A (sh) 2004-09-03
HRP20010747A2 (en) 2002-12-31
ZA200108220B (en) 2006-02-26
CA2368815A1 (en) 2000-10-26
CN1679586A (zh) 2005-10-12
HUP0200839A3 (en) 2003-05-28
IL146023A0 (en) 2002-07-25
CN1680365A (zh) 2005-10-12
RU2001128229A (ru) 2003-07-10
TR200103028T2 (tr) 2002-01-21
CZ20013658A3 (cs) 2002-08-14
WO2000062782A1 (en) 2000-10-26
HK1044116A1 (zh) 2002-10-11
HUP0200839A2 (en) 2002-08-28
CN1356903A (zh) 2002-07-03

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WD01 Invention patent application deemed withdrawn after publication