HK1044116A1 - 含哌嗪环化合物的新型合成和结晶方法 - Google Patents

含哌嗪环化合物的新型合成和结晶方法 Download PDF

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Publication number
HK1044116A1
HK1044116A1 HK02105027.4A HK02105027A HK1044116A1 HK 1044116 A1 HK1044116 A1 HK 1044116A1 HK 02105027 A HK02105027 A HK 02105027A HK 1044116 A1 HK1044116 A1 HK 1044116A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
piperazine
methyl
mirtazapine
present
Prior art date
Application number
HK02105027.4A
Other languages
English (en)
Chinese (zh)
Inventor
Singer Claude
Liberman Anita
Finkelstein Nina
Original Assignee
Teva Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Limited filed Critical Teva Pharmaceutical Industries Limited
Publication of HK1044116A1 publication Critical patent/HK1044116A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK02105027.4A 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法 HK1044116A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13004799P 1999-04-19 1999-04-19
US60/130,047 1999-04-19
PCT/US2000/010357 WO2000062782A1 (en) 1999-04-19 2000-04-18 Novel synthesis and crystallization of piperazine ring-containing compounds

Publications (1)

Publication Number Publication Date
HK1044116A1 true HK1044116A1 (zh) 2002-10-11

Family

ID=22442814

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02105027.4A HK1044116A1 (zh) 1999-04-19 2000-04-18 含哌嗪环化合物的新型合成和结晶方法

Country Status (16)

Country Link
JP (1) JP2004500324A (enExample)
KR (1) KR20020019902A (enExample)
CN (4) CN1679586A (enExample)
CA (1) CA2368815A1 (enExample)
CZ (1) CZ20013658A3 (enExample)
HK (1) HK1044116A1 (enExample)
HR (1) HRP20010747A2 (enExample)
HU (1) HUP0200839A3 (enExample)
IL (1) IL146023A0 (enExample)
PL (1) PL366289A1 (enExample)
RU (1) RU2001128229A (enExample)
SK (1) SK14672001A3 (enExample)
TR (1) TR200103028T2 (enExample)
WO (1) WO2000062782A1 (enExample)
YU (1) YU74101A (enExample)
ZA (1) ZA200108220B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038329A1 (en) * 1999-11-24 2001-05-31 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine crystals and process for producing the same
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
ES2246161B1 (es) * 2004-07-22 2007-04-01 Medichem, S.A. Proceso mejorado para la fabricacion de mirtazapina.
JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
WO2008125578A2 (en) 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of mirtazapine
KR101485418B1 (ko) 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
JP2017088564A (ja) * 2015-11-13 2017-05-25 株式会社トクヤマ ミルタザピンの製造方法
JP6571497B2 (ja) * 2015-11-13 2019-09-04 株式会社トクヤマ ミルタザピンの製造方法
CN108191873B (zh) * 2018-01-08 2021-09-24 山东省食品药品检验研究院 一种盐酸米安色林的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Also Published As

Publication number Publication date
CZ20013658A3 (cs) 2002-08-14
CN1680374A (zh) 2005-10-12
HRP20010747A2 (en) 2002-12-31
CA2368815A1 (en) 2000-10-26
CN1679586A (zh) 2005-10-12
ZA200108220B (en) 2006-02-26
WO2000062782A1 (en) 2000-10-26
HUP0200839A3 (en) 2003-05-28
JP2004500324A (ja) 2004-01-08
HUP0200839A2 (en) 2002-08-28
SK14672001A3 (sk) 2002-11-06
RU2001128229A (ru) 2003-07-10
PL366289A1 (en) 2005-01-24
IL146023A0 (en) 2002-07-25
YU74101A (sh) 2004-09-03
CN1356903A (zh) 2002-07-03
TR200103028T2 (tr) 2002-01-21
CN1680365A (zh) 2005-10-12
KR20020019902A (ko) 2002-03-13

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