CA2368815A1 - Novel synthesis and crystallization of piperazine ring-containing compounds - Google Patents
Novel synthesis and crystallization of piperazine ring-containing compounds Download PDFInfo
- Publication number
- CA2368815A1 CA2368815A1 CA002368815A CA2368815A CA2368815A1 CA 2368815 A1 CA2368815 A1 CA 2368815A1 CA 002368815 A CA002368815 A CA 002368815A CA 2368815 A CA2368815 A CA 2368815A CA 2368815 A1 CA2368815 A1 CA 2368815A1
- Authority
- CA
- Canada
- Prior art keywords
- mirtazapine
- phenyl
- methyl
- piperazine
- cyanopyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13004799P | 1999-04-19 | 1999-04-19 | |
| US60/130,047 | 1999-04-19 | ||
| PCT/US2000/010357 WO2000062782A1 (en) | 1999-04-19 | 2000-04-18 | Novel synthesis and crystallization of piperazine ring-containing compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2368815A1 true CA2368815A1 (en) | 2000-10-26 |
Family
ID=22442814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002368815A Abandoned CA2368815A1 (en) | 1999-04-19 | 2000-04-18 | Novel synthesis and crystallization of piperazine ring-containing compounds |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JP2004500324A (enExample) |
| KR (1) | KR20020019902A (enExample) |
| CN (4) | CN1679586A (enExample) |
| CA (1) | CA2368815A1 (enExample) |
| CZ (1) | CZ20013658A3 (enExample) |
| HK (1) | HK1044116A1 (enExample) |
| HR (1) | HRP20010747A2 (enExample) |
| HU (1) | HUP0200839A3 (enExample) |
| IL (1) | IL146023A0 (enExample) |
| PL (1) | PL366289A1 (enExample) |
| RU (1) | RU2001128229A (enExample) |
| SK (1) | SK14672001A3 (enExample) |
| TR (1) | TR200103028T2 (enExample) |
| WO (1) | WO2000062782A1 (enExample) |
| YU (1) | YU74101A (enExample) |
| ZA (1) | ZA200108220B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001038329A1 (en) * | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
| WO2001042239A1 (en) * | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| US6660730B2 (en) * | 2000-11-27 | 2003-12-09 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine and process for preparing the same |
| UA83666C2 (ru) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
| ES2246161B1 (es) * | 2004-07-22 | 2007-04-01 | Medichem, S.A. | Proceso mejorado para la fabricacion de mirtazapina. |
| JP4848704B2 (ja) * | 2004-08-24 | 2011-12-28 | 住友化学株式会社 | ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法 |
| JP5192707B2 (ja) | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
| US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
| WO2008125578A2 (en) | 2007-04-11 | 2008-10-23 | N.V. Organon | A method for the preparation of mirtazapine |
| KR101485418B1 (ko) | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
| JP2017088564A (ja) * | 2015-11-13 | 2017-05-25 | 株式会社トクヤマ | ミルタザピンの製造方法 |
| JP6571497B2 (ja) * | 2015-11-13 | 2019-09-04 | 株式会社トクヤマ | ミルタザピンの製造方法 |
| CN108191873B (zh) * | 2018-01-08 | 2021-09-24 | 山东省食品药品检验研究院 | 一种盐酸米安色林的纯化方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
-
2000
- 2000-04-18 HK HK02105027.4A patent/HK1044116A1/zh unknown
- 2000-04-18 CN CNA2005100042880A patent/CN1679586A/zh active Pending
- 2000-04-18 KR KR1020017013267A patent/KR20020019902A/ko not_active Abandoned
- 2000-04-18 HU HU0200839A patent/HUP0200839A3/hu unknown
- 2000-04-18 CA CA002368815A patent/CA2368815A1/en not_active Abandoned
- 2000-04-18 SK SK1467-2001A patent/SK14672001A3/sk unknown
- 2000-04-18 CN CNA2005100042895A patent/CN1680374A/zh active Pending
- 2000-04-18 YU YU74101A patent/YU74101A/sh unknown
- 2000-04-18 IL IL14602300A patent/IL146023A0/xx unknown
- 2000-04-18 CZ CZ20013658A patent/CZ20013658A3/cs unknown
- 2000-04-18 TR TR2001/03028T patent/TR200103028T2/xx unknown
- 2000-04-18 HR HR20010747A patent/HRP20010747A2/hr not_active Application Discontinuation
- 2000-04-18 WO PCT/US2000/010357 patent/WO2000062782A1/en not_active Ceased
- 2000-04-18 RU RU2001128229/04A patent/RU2001128229A/ru not_active Application Discontinuation
- 2000-04-18 CN CN00807574A patent/CN1356903A/zh active Pending
- 2000-04-18 JP JP2000611918A patent/JP2004500324A/ja not_active Withdrawn
- 2000-04-18 PL PL00366289A patent/PL366289A1/xx unknown
- 2000-04-18 CN CNA2005100042908A patent/CN1680365A/zh active Pending
-
2001
- 2001-10-05 ZA ZA200108220A patent/ZA200108220B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013658A3 (cs) | 2002-08-14 |
| CN1680374A (zh) | 2005-10-12 |
| HRP20010747A2 (en) | 2002-12-31 |
| CN1679586A (zh) | 2005-10-12 |
| ZA200108220B (en) | 2006-02-26 |
| WO2000062782A1 (en) | 2000-10-26 |
| HUP0200839A3 (en) | 2003-05-28 |
| JP2004500324A (ja) | 2004-01-08 |
| HUP0200839A2 (en) | 2002-08-28 |
| SK14672001A3 (sk) | 2002-11-06 |
| RU2001128229A (ru) | 2003-07-10 |
| PL366289A1 (en) | 2005-01-24 |
| IL146023A0 (en) | 2002-07-25 |
| YU74101A (sh) | 2004-09-03 |
| CN1356903A (zh) | 2002-07-03 |
| TR200103028T2 (tr) | 2002-01-21 |
| CN1680365A (zh) | 2005-10-12 |
| KR20020019902A (ko) | 2002-03-13 |
| HK1044116A1 (zh) | 2002-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20070418 |