KR20020019902A - 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 - Google Patents

피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 Download PDF

Info

Publication number
KR20020019902A
KR20020019902A KR1020017013267A KR20017013267A KR20020019902A KR 20020019902 A KR20020019902 A KR 20020019902A KR 1020017013267 A KR1020017013267 A KR 1020017013267A KR 20017013267 A KR20017013267 A KR 20017013267A KR 20020019902 A KR20020019902 A KR 20020019902A
Authority
KR
South Korea
Prior art keywords
mirtazapine
phenyl
methyl
piperazine
cyanopyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020017013267A
Other languages
English (en)
Korean (ko)
Inventor
클라우드 싱어
아니타 리버만
니나 핀켈스타인
Original Assignee
추후보정
테바 파마슈티컬 인더스트리즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후보정, 테바 파마슈티컬 인더스트리즈 리미티드 filed Critical 추후보정
Publication of KR20020019902A publication Critical patent/KR20020019902A/ko
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020017013267A 1999-04-19 2000-04-18 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 Abandoned KR20020019902A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13004799P 1999-04-19 1999-04-19
US60/130,047 1999-04-19
PCT/US2000/010357 WO2000062782A1 (en) 1999-04-19 2000-04-18 Novel synthesis and crystallization of piperazine ring-containing compounds

Publications (1)

Publication Number Publication Date
KR20020019902A true KR20020019902A (ko) 2002-03-13

Family

ID=22442814

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017013267A Abandoned KR20020019902A (ko) 1999-04-19 2000-04-18 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법

Country Status (16)

Country Link
JP (1) JP2004500324A (enExample)
KR (1) KR20020019902A (enExample)
CN (4) CN1679586A (enExample)
CA (1) CA2368815A1 (enExample)
CZ (1) CZ20013658A3 (enExample)
HK (1) HK1044116A1 (enExample)
HR (1) HRP20010747A2 (enExample)
HU (1) HUP0200839A3 (enExample)
IL (1) IL146023A0 (enExample)
PL (1) PL366289A1 (enExample)
RU (1) RU2001128229A (enExample)
SK (1) SK14672001A3 (enExample)
TR (1) TR200103028T2 (enExample)
WO (1) WO2000062782A1 (enExample)
YU (1) YU74101A (enExample)
ZA (1) ZA200108220B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038329A1 (en) * 1999-11-24 2001-05-31 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine crystals and process for producing the same
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
ES2246161B1 (es) * 2004-07-22 2007-04-01 Medichem, S.A. Proceso mejorado para la fabricacion de mirtazapina.
JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
WO2008125578A2 (en) 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of mirtazapine
JP2017088564A (ja) * 2015-11-13 2017-05-25 株式会社トクヤマ ミルタザピンの製造方法
JP6571497B2 (ja) * 2015-11-13 2019-09-04 株式会社トクヤマ ミルタザピンの製造方法
CN108191873B (zh) * 2018-01-08 2021-09-24 山东省食品药品检验研究院 一种盐酸米安色林的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법

Also Published As

Publication number Publication date
CZ20013658A3 (cs) 2002-08-14
CN1680374A (zh) 2005-10-12
HRP20010747A2 (en) 2002-12-31
CA2368815A1 (en) 2000-10-26
CN1679586A (zh) 2005-10-12
ZA200108220B (en) 2006-02-26
WO2000062782A1 (en) 2000-10-26
HUP0200839A3 (en) 2003-05-28
JP2004500324A (ja) 2004-01-08
HUP0200839A2 (en) 2002-08-28
SK14672001A3 (sk) 2002-11-06
RU2001128229A (ru) 2003-07-10
PL366289A1 (en) 2005-01-24
IL146023A0 (en) 2002-07-25
YU74101A (sh) 2004-09-03
CN1356903A (zh) 2002-07-03
TR200103028T2 (tr) 2002-01-21
CN1680365A (zh) 2005-10-12
HK1044116A1 (zh) 2002-10-11

Similar Documents

Publication Publication Date Title
FI71126B (fi) Foerfarande foer framstaellning av n-(1-alkyl- eller allyl-2-pyrrolidinylmetyl)-2-metoxi-4-amino-5-alkylsulfonylbensamider
KR20020019902A (ko) 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법
HK1003226A1 (en) Process for the preparation of substituted indolinone derivatives
FI84913B (fi) Foerfarande foer framstaellning av 2-alkoxi-n-(1-azabicyclo/2.2.2./oktan-3-yl)aminobensamider.
US5142053A (en) Process for the preparation of 1-(2,3,4-trimethoxybenzyl)piperazine by reductive animation
EP0028698B1 (en) Quinoline compounds, process for their preparation, and pharmaceutical compositions
US6576764B2 (en) Synthesis and crystallization of piperazine ring-containing compounds
IE46908B1 (en) Pyridobenzodiazepines
US20030069417A1 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
EP0055068A1 (en) Quinolone derivatives and their use as pharmaceuticals
CN115894303B (zh) 一种(3-氨基双环[1.1.1]戊烷-1-基)氨基甲酸叔丁酯及其中间体的制备方法
AU781221B2 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
US4146713A (en) Method of preparing 3-morpholino-2-cyanoacrylamide
AU2005201117A1 (en) Novel synthesis and crystallization of piperazine ring-containing compounds
US3803177A (en) Process for production of eriodictyol
CN112521298B (zh) 一种利多卡因的合成方法
EP0013726B1 (en) Indanyloxamic derivatives, their preparation and pharmaceutical compositions containing them
EP0026675B1 (en) 1-azaxanthone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them
PL82685B1 (en) Dibenzazepine derivatives and their preparation[ie34441b1]
KR810000817B1 (ko) N,n-디메틸-3-(4-브로모페닐)-3-(3-피리딜)-알릴아민의 제조방법
IE43503B1 (en) Acid accition salt of a substituted pyrido-dioxin derivative
JPS59184184A (ja) ７，８，９，１０−テトラヒドロチエノ〔３，２−ｅ〕ピリド〔４，３−ｂ〕−インド−ル、その製造法及びそれらを含む医薬
JPH02108684A (ja) ベンゾピラン誘導体の製造法
JPS6156236B2 (enExample)
NO772673L (no) Fremgangsm}te ved fremstilling av d-2-(6-methoxy-2-nafthyl)-propionsyre

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

N231 Notification of change of applicant
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PC1902 Submission of document of abandonment before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1902

SUBM Surrender of laid-open application requested
R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000