MXPA05005571A - Metodo para producir sales de tolperisona. - Google Patents
Metodo para producir sales de tolperisona.Info
- Publication number
- MXPA05005571A MXPA05005571A MXPA05005571A MXPA05005571A MXPA05005571A MX PA05005571 A MXPA05005571 A MX PA05005571A MX PA05005571 A MXPA05005571 A MX PA05005571A MX PA05005571 A MXPA05005571 A MX PA05005571A MX PA05005571 A MXPA05005571 A MX PA05005571A
- Authority
- MX
- Mexico
- Prior art keywords
- tolperisone
- acid
- addition salt
- producing salts
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
La invencion se refiere a un metodo para producir una sal acida de adicion de 2,4'-dimetil-3-piperidinopropiofenona (tolperisona) con un acido farmaceuticamente aceptable, de la formula (I) (ver formula (I)). De acuerdo con la invencion, la 4-metilpropiofenona hace reaccion con el clorhidrato de piperidina y 1,2-dioxolano en presencia de un acido que sirve como un catalizador y la tolperisona obtenida en forma de una sal acida de adicion es separada por filtracion despues de que la mezcla de reaccion se ha enfriado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0182302A AT413539B (de) | 2002-12-05 | 2002-12-05 | Verfahren zum herstellen von salzen des tolperison |
PCT/AT2003/000092 WO2004050648A1 (de) | 2002-12-05 | 2003-03-31 | Verfahren zum herstellen von salzen des tolperison |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05005571A true MXPA05005571A (es) | 2005-10-18 |
Family
ID=32398619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05005571A MXPA05005571A (es) | 2002-12-05 | 2003-03-31 | Metodo para producir sales de tolperisona. |
Country Status (15)
Country | Link |
---|---|
US (2) | US7385060B2 (es) |
EP (1) | EP1567510B1 (es) |
AT (2) | AT413539B (es) |
AU (1) | AU2003227075A1 (es) |
CA (1) | CA2507691C (es) |
DE (1) | DE50306068D1 (es) |
DK (1) | DK1567510T3 (es) |
ES (1) | ES2275140T3 (es) |
HK (1) | HK1085199A1 (es) |
HR (1) | HRP20050501A2 (es) |
MX (1) | MXPA05005571A (es) |
NO (1) | NO20053176L (es) |
PL (1) | PL378082A1 (es) |
PT (1) | PT1567510E (es) |
WO (1) | WO2004050648A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT413539B (de) * | 2002-12-05 | 2006-03-15 | Sanochemia Pharmazeutika Ag | Verfahren zum herstellen von salzen des tolperison |
DE102005014080B4 (de) * | 2005-03-21 | 2007-11-22 | Birds Pharma Gmbh Berolina Innovative Research & Development Services | Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel |
AT505225A1 (de) | 2007-04-26 | 2008-11-15 | Sanochemia Pharmazeutika Ag | 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen |
US20100249423A1 (en) * | 2009-03-09 | 2010-09-30 | Sanochemia Pharmazeutika Ag | Tolperisone controlled release tablet |
CN107868065B (zh) * | 2017-10-19 | 2021-05-18 | 湖北美林药业有限公司 | 一种盐酸托哌酮化合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5295674A (en) * | 1976-02-09 | 1977-08-11 | Nippon Carbide Ind Co Ltd | Preparation of 4#-substituted-2-methyl-2-piperidinopropiophenone and i ts salts |
AT413539B (de) * | 2002-12-05 | 2006-03-15 | Sanochemia Pharmazeutika Ag | Verfahren zum herstellen von salzen des tolperison |
-
2002
- 2002-12-05 AT AT0182302A patent/AT413539B/de not_active IP Right Cessation
-
2003
- 2003-03-31 AU AU2003227075A patent/AU2003227075A1/en not_active Abandoned
- 2003-03-31 MX MXPA05005571A patent/MXPA05005571A/es active IP Right Grant
- 2003-03-31 PL PL378082A patent/PL378082A1/pl not_active Application Discontinuation
- 2003-03-31 EP EP03812092A patent/EP1567510B1/de not_active Expired - Lifetime
- 2003-03-31 ES ES03812092T patent/ES2275140T3/es not_active Expired - Lifetime
- 2003-03-31 DE DE50306068T patent/DE50306068D1/de not_active Expired - Fee Related
- 2003-03-31 WO PCT/AT2003/000092 patent/WO2004050648A1/de active IP Right Grant
- 2003-03-31 PT PT03812092T patent/PT1567510E/pt unknown
- 2003-03-31 DK DK03812092T patent/DK1567510T3/da active
- 2003-03-31 CA CA2507691A patent/CA2507691C/en not_active Expired - Fee Related
- 2003-03-31 US US10/537,434 patent/US7385060B2/en active Active
- 2003-03-31 AT AT03812092T patent/ATE348821T1/de not_active IP Right Cessation
-
2005
- 2005-06-03 HR HR20050501A patent/HRP20050501A2/xx not_active Application Discontinuation
- 2005-06-28 NO NO20053176A patent/NO20053176L/no not_active Application Discontinuation
-
2006
- 2006-02-28 HK HK06102666A patent/HK1085199A1/xx not_active IP Right Cessation
-
2008
- 2008-04-04 US US12/080,605 patent/US20080188522A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2275140T3 (es) | 2007-06-01 |
PT1567510E (pt) | 2007-02-28 |
HRP20050501A2 (en) | 2005-08-31 |
CA2507691C (en) | 2010-10-12 |
AU2003227075A1 (en) | 2004-06-23 |
AT413539B (de) | 2006-03-15 |
HK1085199A1 (en) | 2006-08-18 |
US20080188522A1 (en) | 2008-08-07 |
ATA18232002A (de) | 2005-08-15 |
ATE348821T1 (de) | 2007-01-15 |
NO20053176L (no) | 2005-09-05 |
US20060041141A1 (en) | 2006-02-23 |
PL378082A1 (pl) | 2006-02-20 |
US7385060B2 (en) | 2008-06-10 |
CA2507691A1 (en) | 2004-06-17 |
NO20053176D0 (no) | 2005-06-28 |
EP1567510B1 (de) | 2006-12-20 |
WO2004050648A1 (de) | 2004-06-17 |
DK1567510T3 (da) | 2007-04-02 |
EP1567510A1 (de) | 2005-08-31 |
DE50306068D1 (de) | 2007-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA80834C2 (en) | Method of synthesising ivabradine and the salts thereof for addition to a pharmaceutically acceptable acid | |
GEP20074135B (en) | Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)- benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
SI1781683T1 (sl) | Postopek za pripravo 17-vinil-triflatov kot intermediatov | |
HK1085199A1 (en) | Method for producing salts of tolperisone | |
DE60306667D1 (de) | Cefdinir salze als zwischenprodukte | |
MXPA03005429A (es) | Procedimiento para preparacion de imidazotriazinonas sustituidas con sulfonamida. | |
UA85428C2 (ru) | Способ получения с-2, с-3 замещенных n-алкилированных индолов, а также промежуточные соединения и способы их получения | |
EP1484301A4 (en) | PROCESS FOR PREPARING A TRANS-4-AMINO-1-CYCLOHEXANCARBOXYLIC ACID DERIVATIVE | |
HK1075052A1 (en) | Intermediates for lhrh antagonist synthesis, proc ess for their production, and process for lhrh antagonist production | |
WO2004080959A3 (en) | Process for the preparation of dexmethylphenidate hydrochloride | |
ATE245624T1 (de) | Verfahren zur herstellung substituierter allylamin derivative und deren salze | |
EP1460065A4 (en) | METHOD FOR THE PRODUCTION OF CYCLIC DIAMINO COMPOUNDS BZW. THE SALTS | |
IL197970A (en) | Process for making piperidinyl-sulfanyl-acetyl-motilines | |
EA200000924A3 (ru) | СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОН-3-ПИРИДИЛСУЛЬФОНИЛЬНЫХ СОЕДИНЕНИЙ И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ | |
EP1415985A4 (en) | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE AZETIDINE-2-CARBOXYLIC ACID | |
WO2003029189A1 (en) | Process for producing (2-nitrophenyl)acetonitrile derivative and intermediate therefor | |
WO2003106440A3 (en) | PROCESS FOR THE SYNTHESIS OF A BENZAMIDE DERIVATIVE | |
WO2004078707A3 (fr) | Nouveau procede de synthese de lacide (2s, 3as, 7as)-perhydroindole-2-carboxylique et de ses esters et application a la synthese du perindopril | |
MXPA05001967A (es) | Proceso para la produccion de derivado de indolopirrolocarbazol. | |
IL178062A0 (en) | Process for preparing cyclohexanediacetic acid monoamide | |
ATE330612T1 (de) | Verfahren zur herstellung von benazeprilhydrochloride | |
BR0312773A (pt) | Método para produzir um composto altamente puro | |
MXPA05008179A (es) | Procedimiento para la fabricacion de alcaloides de quinazolina. | |
MY136549A (en) | NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL | |
ATE414704T1 (de) | Verfahren zur synthese von pergolid |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |