WO2003106440A3 - Process for the synthesis of mosapride - Google Patents
Process for the synthesis of mosapride Download PDFInfo
- Publication number
- WO2003106440A3 WO2003106440A3 PCT/HU2003/000042 HU0300042W WO03106440A3 WO 2003106440 A3 WO2003106440 A3 WO 2003106440A3 HU 0300042 W HU0300042 W HU 0300042W WO 03106440 A3 WO03106440 A3 WO 03106440A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthesis
- mosapride
- citrate
- morpholinyl
- fluoro
- Prior art date
Links
- YPELFRMCRYSPKZ-UHFFFAOYSA-N 4-amino-5-chloro-2-ethoxy-N-({4-[(4-fluorophenyl)methyl]morpholin-2-yl}methyl)benzamide Chemical compound CCOC1=CC(N)=C(Cl)C=C1C(=O)NCC1OCCN(CC=2C=CC(F)=CC=2)C1 YPELFRMCRYSPKZ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960004085 mosapride Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- LRZSAGKIMYFLHY-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;dihydrate Chemical compound O.O.OC(=O)CC(O)(C(O)=O)CC(O)=O LRZSAGKIMYFLHY-UHFFFAOYSA-N 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03760090A EP1515958A2 (en) | 2002-06-13 | 2003-06-12 | Process for the synthesis of mosapride |
AU2003242867A AU2003242867A1 (en) | 2002-06-13 | 2003-06-12 | Process for the synthesis of mosapride |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0201980A HUP0201980A3 (en) | 2002-06-13 | 2002-06-13 | Process for preparing a benzamide derivative and intermediates thereof |
HUP0201980 | 2002-06-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003106440A2 WO2003106440A2 (en) | 2003-12-24 |
WO2003106440A3 true WO2003106440A3 (en) | 2004-06-17 |
Family
ID=89980512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU2003/000042 WO2003106440A2 (en) | 2002-06-13 | 2003-06-12 | Process for the synthesis of a benzamide derivative |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1515958A2 (en) |
AU (1) | AU2003242867A1 (en) |
HU (1) | HUP0201980A3 (en) |
WO (1) | WO2003106440A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100750593B1 (en) * | 2006-03-16 | 2007-08-20 | 동우신테크 주식회사 | Process for preparing substituted benzamide derivatives |
JP2008247753A (en) * | 2007-03-29 | 2008-10-16 | Dainippon Sumitomo Pharma Co Ltd | Method for producing 4-amino-5-chloro-2-ethoxy-n-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide |
KR100986734B1 (en) * | 2008-03-21 | 2010-10-13 | 하나제약 주식회사 | Novel Synthetic Method of Intermediate for Mosapride |
WO2011107903A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Highly pure mosapride citrate dihydrate and processes for its preparation |
CN105301118B (en) * | 2014-07-02 | 2018-05-25 | 成都康弘药业集团股份有限公司 | A kind of detection method of mosapride citrate in relation to substance |
KR102275045B1 (en) * | 2019-02-13 | 2021-07-08 | 한국바이오켐제약 주식회사 | Methods for preparing mosapride citrate hydrate and pharmaceutical composition comprising the same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0243959A1 (en) * | 1986-04-30 | 1987-11-04 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same |
EP0640601A1 (en) * | 1991-02-15 | 1995-03-01 | Hokuriku Seiyaku Co., Ltd. | Benzamide derivative |
WO1996034851A1 (en) * | 1995-05-03 | 1996-11-07 | Abbott Laboratories | Benzene, pyridine, naphtalene or benzophenone derivatives as inhibitors of squalene synthetase and protein farnesyltransferase |
-
2002
- 2002-06-13 HU HU0201980A patent/HUP0201980A3/en unknown
-
2003
- 2003-06-12 WO PCT/HU2003/000042 patent/WO2003106440A2/en not_active Application Discontinuation
- 2003-06-12 EP EP03760090A patent/EP1515958A2/en not_active Withdrawn
- 2003-06-12 AU AU2003242867A patent/AU2003242867A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0243959A1 (en) * | 1986-04-30 | 1987-11-04 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same |
EP0640601A1 (en) * | 1991-02-15 | 1995-03-01 | Hokuriku Seiyaku Co., Ltd. | Benzamide derivative |
WO1996034851A1 (en) * | 1995-05-03 | 1996-11-07 | Abbott Laboratories | Benzene, pyridine, naphtalene or benzophenone derivatives as inhibitors of squalene synthetase and protein farnesyltransferase |
Non-Patent Citations (1)
Title |
---|
KATO S ET AL: "NOVEL BENZAMIDES AS SELECTIVE AND POTENT GASTROKINETIC AGENTS 2. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-AMINO-5-CHLORO-2-ETHOXY-N-4-(4-FLUOROBENZYL)-2-MORPHOLINYL METHYLBENZAMIDE CITRATE (AS-4370) AND RELATED COMPOUNDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 34, no. 2, February 1991 (1991-02-01), pages 616 - 624, XP001037842, ISSN: 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
HUP0201980A3 (en) | 2008-06-30 |
EP1515958A2 (en) | 2005-03-23 |
WO2003106440A2 (en) | 2003-12-24 |
AU2003242867A1 (en) | 2003-12-31 |
HUP0201980A2 (en) | 2004-03-01 |
HU0201980D0 (en) | 2002-08-28 |
AU2003242867A8 (en) | 2003-12-31 |
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